Article: Interferon dysregulation and virus-induced cell death in avian influenza H5N1 virus infections.
Hong Kong medical journal = Xianggang yi xue za zhi
2012 Volume 18 Suppl 2, Page(s) 12–16
Abstract: ... with the avian influenza H5N1 and H9N2/G1 viruses, as compared to those infected with human influenza H1N1 virus. 2. IRF3 ... Compared with H1N1 viruses, avian influenza viruses including H5N1/97 and its precursors triggered ... 1, and TNF-α, and also played a part in subsequent cytokine-induced cell signalling cascades. 3 ...
| Abstract | 1. Hyper-induction of cytokines and chemokines was found in human blood macrophages infected with the avian influenza H5N1 and H9N2/G1 viruses, as compared to those infected with human influenza H1N1 virus. 2. IRF3 played a significant role in the hyperinduction of cytokines including IFN-β, IFN-λ1,IFN-α subtypes, MCP-1, and TNF-α, and also played a part in subsequent cytokine-induced cell signalling cascades. 3. Compared with H1N1 viruses, avian influenza viruses including H5N1/97 and its precursors triggered a caspase-mediated but delayed apoptotic response in human macrophages. 4. Therapies that can minimise immunopathology-associated dysregulation of innate immunity without impairing effective host defence may be valuable adjuncts to antiviral therapy. |
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| MeSH term(s) | Apoptosis ; Caspase 3/metabolism ; Cells, Cultured ; Cytokines/biosynthesis ; Cytokines/genetics ; Gene Expression Regulation ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza A Virus, H5N1 Subtype ; Influenza, Human/metabolism ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; Interferon-beta/biosynthesis ; Interferon-beta/genetics ; Interferons ; Interleukins/biosynthesis ; Interleukins/genetics ; Macrophages/enzymology ; Macrophages/metabolism ; Macrophages/virology ; Poly(ADP-ribose) Polymerases/metabolism ; RNA, Messenger/metabolism ; RNA, Small Interfering ; Transcription Factors/metabolism ; Tumor Necrosis Factor-alpha/biosynthesis ; Tumor Necrosis Factor-alpha/genetics ; Up-Regulation/genetics | |||||
| Chemical Substances | Cytokines ; interferon-lambda, human ; IRF3 protein, human ; Interferon Regulatory Factor-3 ; Interleukins ; RNA, Messenger ; RNA, Small Interfering ; Transcription Factors ; Tumor Necrosis Factor-alpha ; Interferon-beta (77238-31-4) ; Interferons (9008-11-1) ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; Caspase 3 (EC 3.4.22.-) | |||||
| Language | English | |||||
| Publishing date | 2012-02-06 | |||||
| Publishing country | China | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 1239255-8 | |||||
| ISSN | 1024-2708 | |||||
| ISSN | 1024-2708 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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