Article ; Online: AlGaN/GaN High Electron Mobility Transistor-Based Biosensor for the Detection of C-Reactive Protein.
2015 Volume 15, Issue 8, Page(s) 18416–18426
Abstract: In this paper, we propose an AlGaN/GaN high electron mobility transistor (HEMT)-based biosensor ... varied by antigen-antibody interactions on the gate surface due to CRP charges. The AlGaN/GaN HFET-based biosensor ... for the detection of C-reactive protein (CRP) using a null-balancing circuit. A null-balancing circuit was used ...
| Abstract | In this paper, we propose an AlGaN/GaN high electron mobility transistor (HEMT)-based biosensor for the detection of C-reactive protein (CRP) using a null-balancing circuit. A null-balancing circuit was used to measure the output voltage of the sensor directly. The output voltage of the proposed biosensor was varied by antigen-antibody interactions on the gate surface due to CRP charges. The AlGaN/GaN HFET-based biosensor with null-balancing circuit applied shows that CRP can be detected in a wide range of concentrations, varying from 10 ng/mL to 1000 ng/mL. X-ray photoelectron spectroscopy was carried out to verify the immobilization of self-assembled monolayer with Au on the gated region. |
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| MeSH term(s) | Aluminum Compounds/chemistry ; Biosensing Techniques/instrumentation ; C-Reactive Protein/analysis ; Electricity ; Electrons ; Gallium/chemistry ; Humans ; Photoelectron Spectroscopy ; Transistors, Electronic |
| Chemical Substances | Aluminum Compounds ; aluminum gallium nitride ; gallium nitride (1R9CC3P9VL) ; C-Reactive Protein (9007-41-4) ; Gallium (CH46OC8YV4) |
| Language | English |
| Publishing date | 2015-07-28 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2052857-7 |
| ISSN | 1424-8220 ; 1424-8220 |
| ISSN (online) | 1424-8220 |
| ISSN | 1424-8220 |
| DOI | 10.3390/s150818416 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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