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Article ; Online: Association between red blood cell distribution width and mortality and severity among patients with COVID-19: A systematic review and meta-analysis.

Lee, Jane J / Montazerin, Sahar M / Jamil, Adeel / Jamil, Umer / Marszalek, Jolanta / Chuang, Michael L / Chi, Gerald

Journal of medical virology

2021  Volume 93, Issue 4, Page(s) 2513–2522

Abstract: Emerging evidence has underscored the potential usefulness of red blood cell distribution width ... RDW) measurement in predicting the mortality and disease severity of COVID-19. This study aimed ... in the meta-analysis. Higher levels of RDW were associated with adverse outcomes in COVID-19 patients (mean differences ...

Abstract Emerging evidence has underscored the potential usefulness of red blood cell distribution width (RDW) measurement in predicting the mortality and disease severity of COVID-19. This study aimed to assess the association of the plasma RDW levels with adverse prognosis in COVID-19 patients. A comprehensive literature search from inception to September 2020 was performed to harvest original studies reporting RDW on admission and clinical outcomes among patients hospitalized with COVID-19. RDW levels were compared between cases (patients who died or developed more severe symptoms) and controls (patients who survived or developed less severe symptoms). A total of 14,866 subjects from 10 studies were included in the meta-analysis. Higher levels of RDW were associated with adverse outcomes in COVID-19 patients (mean differences = 0.72; 95% CI = 0.47-0.97; I
MeSH term(s) Biomarkers/blood ; COVID-19/blood ; COVID-19/mortality ; COVID-19/virology ; Databases, Factual ; Erythrocyte Indices ; Erythrocytes/pathology ; Hospital Mortality ; Humans ; Prognosis ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
Chemical Substances Biomarkers
Language English
Publishing date 2021-01-26
Publishing country United States
Document type Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID 752392-0
ISSN 1096-9071 ; 0146-6615
ISSN (online) 1096-9071
ISSN 0146-6615
DOI 10.1002/jmv.26797
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