Article ; Online: Prospects for atherosclerosis regression through increase in high-density lipoprotein and other emerging therapeutic targets.
Heart (British Cardiac Society)
2006 Volume 93, Issue 5, Page(s) 559–564
Abstract: ... events, and the magnitude of effect on plaque regression seems relatively modest. High-density ... of gene transcription have revealed new targets for atherosclerosis treatment. This review considers emerging approaches ... Beyond HDL-C increases, further appreciation of mechanisms of cellular lipid homoeostasis and regulation ...
| Abstract | In a process often seen as progressive and irreversible, deposition and retention of lipoproteins and the consequent inflammatory reaction result in the accumulation of atherosclerotic plaques from an early age. However, striking effects observed in experimental models support the concept that atherosclerosis can regress. This is often accompanied by changes in plaque composition favouring stability and decreased likelihood of rupture. Large clinical trials have established the value of low-density lipoprotein cholesterol reduction with statin treatment, although this may prevent no more than 30% of all cardiovascular events, and the magnitude of effect on plaque regression seems relatively modest. High-density lipoprotein cholesterol (HDL-C) is well recognised as an important and independent protective factor, although treatment options to increase HDL-C have until now been limited. The recent emergence of new treatments will probably establish increased HDL-C as another important strategy in antiatherosclerosis treatment. Beyond HDL-C increases, further appreciation of mechanisms of cellular lipid homoeostasis and regulation of gene transcription have revealed new targets for atherosclerosis treatment. This review considers emerging approaches to plaque regression together with some of the parallel developments in imaging technology that will improve our appreciation of response to treatment. |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MeSH term(s) | Atherosclerosis/diagnosis ; Atherosclerosis/prevention & control ; Cholesterol, HDL/drug effects ; Cholesterol, HDL/metabolism ; Cholesterol, HDL/therapeutic use ; Cholesterol, LDL/drug effects ; Humans ; Magnetic Resonance Angiography/methods | ||||||||||
| Chemical Substances | Cholesterol, HDL ; Cholesterol, LDL | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2006-01-31 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Journal Article ; Review | ||||||||||
| ZDB-ID | 1303417-0 | ||||||||||
| ISSN | 1468-201X ; 1355-6037 | ||||||||||
| ISSN (online) | 1468-201X | ||||||||||
| ISSN | 1355-6037 | ||||||||||
| DOI | 10.1136/hrt.2005.066050 | ||||||||||
| Shelf mark |
|
||||||||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Ui IV Zs.40: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
|||
| Zs.MO 112: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.