Article: Hyperinduction of cyclooxygenase-2-mediated proinflammatory cascade: a mechanism for the pathogenesis of avian influenza H5N1 infection.
The Journal of infectious diseases
2008 Volume 198, Issue 4, Page(s) 525–535
Abstract: ... that cyclooxygenase-2 (COX-2) was strongly induced in H5N1-infected macrophages in vitro and in epithelial cells ... role for COX-2 in the H5N1-hyperinduced host proinflammatory cascade. These data provide a basis ... proinflammatory cascade are broader than those arising from direct viral infection. Furthermore, selective COX-2 ...
| Abstract | The mechanism for the pathogenesis of H5N1 infection in humans remains unclear. This study reveals that cyclooxygenase-2 (COX-2) was strongly induced in H5N1-infected macrophages in vitro and in epithelial cells of lung tissue samples obtained during autopsy of patients who died of H5N1 disease. Novel findings demonstrated that COX-2, along with tumor necrosis factor alpha and other proinflammatory cytokines were hyperinduced in epithelial cells by secretory factors from H5N1-infected macrophages in vitro. This amplification of the proinflammatory response is rapid, and the effects elicited by the H5N1-triggered proinflammatory cascade are broader than those arising from direct viral infection. Furthermore, selective COX-2 inhibitors suppress the hyperinduction of cytokines in the proinflammatory cascade, indicating a regulatory role for COX-2 in the H5N1-hyperinduced host proinflammatory cascade. These data provide a basis for the possible development of novel therapeutic interventions for the treatment of H5N1 disease, as adjuncts to antiviral drugs. |
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| MeSH term(s) | Animals ; Birds ; Cyclooxygenase 2/biosynthesis ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2 Inhibitors ; Humans ; Influenza A Virus, H5N1 Subtype/genetics ; Influenza A Virus, H5N1 Subtype/immunology ; Influenza A Virus, H5N1 Subtype/pathogenicity ; Influenza in Birds/enzymology ; Influenza in Birds/immunology ; Influenza in Birds/virology ; Influenza, Human/enzymology ; Influenza, Human/virology | ||||||||||
| Chemical Substances | Cyclooxygenase 2 Inhibitors ; Cyclooxygenase 2 (EC 1.14.99.1) | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2008-08-15 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | ||||||||||
| ZDB-ID | 3019-3 | ||||||||||
| ISSN | 1537-6613 ; 0022-1899 | ||||||||||
| ISSN (online) | 1537-6613 | ||||||||||
| ISSN | 0022-1899 | ||||||||||
| DOI | 10.1086/590499 | ||||||||||
| Shelf mark |
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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