Article: Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes.
1985 Volume 54, Issue 2, Page(s) 467–472
Abstract: ... We speculate that MCP-1 and MCP-2, peptides that are abundant in rabbit granulocytes and lung macrophages ... 1 or MCP-2 depended on peptide concentration and on the time, temperature, and pH of the incubation ... may contribute to antiviral defenses by mediating the direct inactivation of HSV-1 and selected other viruses. ...
| Abstract | Six homologous peptides were purified to homogeneity from rabbit granulocytes or alveolar macrophages and tested for their ability to inactivate herpes simplex virus type 1 (HSV-1). Two of the peptides, MCP-1 and MCP-2, showed considerable in vitro neutralizing activity, whereas four structurally homologous peptides (NP-3a, NP-3b, NP-4, and NP-5) were relatively ineffective. Inactivation of HSV-1 by MCP-1 or MCP-2 depended on peptide concentration and on the time, temperature, and pH of the incubation. HSV-2, vesicular stomatitis virus, and influenza virus A/WSN were also susceptible to direct neutralization by MCP-1 or MCP-2, whereas cytomegalovirus, echovirus type 11, and reovirus type 3 were not. We speculate that MCP-1 and MCP-2, peptides that are abundant in rabbit granulocytes and lung macrophages, may contribute to antiviral defenses by mediating the direct inactivation of HSV-1 and selected other viruses. |
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| MeSH term(s) | Animals ; Anti-Infective Agents/pharmacology ; Antimicrobial Cationic Peptides ; Leukocytes/analysis ; Leukocytes/immunology ; Proteins/analysis ; Proteins/pharmacology ; Rabbits ; Simplexvirus/drug effects ; Structure-Activity Relationship ; Viruses/drug effects | |||||
| Chemical Substances | Anti-Infective Agents ; Antimicrobial Cationic Peptides ; Proteins | |||||
| Language | English | |||||
| Publishing date | 1985-05 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, U.S. Gov't, P.H.S. | |||||
| ZDB-ID | 80174-4 | |||||
| ISSN | 1098-5514 ; 0022-538X | |||||
| ISSN (online) | 1098-5514 | |||||
| ISSN | 0022-538X | |||||
| DOI | 10.1128/JVI.54.2.467-472.1985 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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