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  1. Article: SARS-CoV-2 orf1b Gene Sequence in the NTNG1 Gene on Human Chromosome 1

    Lehrer, Steven / Rheinstein, Peter H

    In Vivo

    Abstract: ... in the SARS-CoV-2 orf1b (open reading frames) gene. The SARS-CoV-2 human sequence lies within non ... of the complex by the host cell. It is probably no accident that a sequence from the SARS-CoV-2 orf1b gene is ... revealed a 117-base pair SARS-CoV-2 sequence in the human genome with 94.6% identity. The sequence was ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus. It is contagious in humans and is the cause of the coronavirus disease 2019 (COVID-19) pandemic. In the current analysis, we searched for SARS-CoV-2 sequences within the human genome. To compare the SARS-CoV-2 genome to the human genome, we used the blast-like alignment tool (BLAT) of the University of California, Santa Cruz Genome Browser. BLAT can align a user sequence of 25 bases or more to the genome. BLAT search results revealed a 117-base pair SARS-CoV-2 sequence in the human genome with 94.6% identity. The sequence was in chromosome 1p within an intronic region of the netrin G1 (NTNG1) gene. The sequence matched a sequence in the SARS-CoV-2 orf1b (open reading frames) gene. The SARS-CoV-2 human sequence lies within non-structural proteins 14 and 15 (NSP14 and NSP15), and is quite close to the viral spike sequence, separated only by NSP16, a 904-base pair sequence. The mechanism for SARS-CoV-2 infection is the binding of the virus spike protein to the membrane-bound form of angiotensin-converting enzyme 2 and internalization of the complex by the host cell. It is probably no accident that a sequence from the SARS-CoV-2 orf1b gene is found in the human NTNG1 gene, implicated in schizophrenia, and that haloperidol, used to treat schizophrenia, may also be a treatment for COVID-19. We suggest, therefore, that it is important to investigate other haloperidol analogs. Among them are benperidol, bromperidol, bromperidol decanoate, droperidol, seperidol hydrochloride, and trifluperidol. These analogs might be valuable in the treatment of COVID-19 and other coronavirus infections.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #534630
    Database COVID19

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  2. Article ; Online: SARS-CoV-2

    Lehrer, Steven / Rheinstein, Peter H

    In vivo (Athens, Greece)

    2020  Volume 34, Issue 3 Suppl, Page(s) 1629–1632

    Abstract: ... in the SARS-CoV-2 orf1b (open reading frames) gene. The SARS-CoV-2 human sequence lies within non ... of the complex by the host cell. It is probably no accident that a sequence from the SARS-CoV-2 orf1b gene is ... revealed a 117-base pair SARS-CoV-2 sequence in the human genome with 94.6% identity. The sequence was ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus. It is contagious in humans and is the cause of the coronavirus disease 2019 (COVID-19) pandemic. In the current analysis, we searched for SARS-CoV-2 sequences within the human genome. To compare the SARS-CoV-2 genome to the human genome, we used the blast-like alignment tool (BLAT) of the University of California, Santa Cruz Genome Browser. BLAT can align a user sequence of 25 bases or more to the genome. BLAT search results revealed a 117-base pair SARS-CoV-2 sequence in the human genome with 94.6% identity. The sequence was in chromosome 1p within an intronic region of the netrin G1 (NTNG1) gene. The sequence matched a sequence in the SARS-CoV-2 orf1b (open reading frames) gene. The SARS-CoV-2 human sequence lies within non-structural proteins 14 and 15 (NSP14 and NSP15), and is quite close to the viral spike sequence, separated only by NSP16, a 904-base pair sequence. The mechanism for SARS-CoV-2 infection is the binding of the virus spike protein to the membrane-bound form of angiotensin-converting enzyme 2 and internalization of the complex by the host cell. It is probably no accident that a sequence from the SARS-CoV-2 orf1b gene is found in the human NTNG1 gene, implicated in schizophrenia, and that haloperidol, used to treat schizophrenia, may also be a treatment for COVID-19. We suggest, therefore, that it is important to investigate other haloperidol analogs. Among them are benperidol, bromperidol, bromperidol decanoate, droperidol, seperidol hydrochloride, and trifluperidol. These analogs might be valuable in the treatment of COVID-19 and other coronavirus infections.
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Base Sequence ; Betacoronavirus/genetics ; COVID-19 ; Chromosomes, Human, Pair 1/genetics ; Coronavirus Infections/drug therapy ; DNA, Complementary/genetics ; Endoribonucleases/genetics ; Exoribonucleases/genetics ; Genes, Viral ; Haloperidol/analogs & derivatives ; Haloperidol/pharmacology ; Haloperidol/therapeutic use ; Humans ; Introns/genetics ; Netrin-1/genetics ; Pan troglodytes/genetics ; Pandemics ; Pneumonia, Viral/drug therapy ; Polyproteins ; RNA, Viral/genetics ; SARS-CoV-2 ; Schizophrenia/drug therapy ; Schizophrenia/genetics ; Sequence Alignment ; Sequence Homology, Nucleic Acid ; Species Specificity ; Viral Nonstructural Proteins/genetics ; Viral Proteins/genetics
    Chemical Substances Antiviral Agents ; DNA, Complementary ; NTN1 protein, human ; ORF1ab polyprotein, SARS-CoV-2 ; Polyproteins ; RNA, Viral ; Viral Nonstructural Proteins ; Viral Proteins ; Netrin-1 (158651-98-0) ; nsp14 protein, SARS coronavirus (EC 2.1.1.56) ; Endoribonucleases (EC 3.1.-) ; Exoribonucleases (EC 3.1.-) ; NSP14 protein, SARS-CoV-2 (EC 3.1.-) ; nidoviral uridylate-specific endoribonuclease (EC 3.1.-) ; Haloperidol (J6292F8L3D)
    Keywords covid19
    Language English
    Publishing date 2020-06-08
    Publishing country Greece
    Document type Comparative Study ; Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.11953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Human Gene Sequences in SARS-CoV-2 and Other Viruses.

    Lehrer, Steven / Rheinstein, Peter H

    In vivo (Athens, Greece)

    2020  Volume 34, Issue 3 Suppl, Page(s) 1633–1636

    Abstract: ... within an intronic region of the netrin G1 (NTNG1) gene. The sequence matched a sequence in the SARS-CoV-2 Orf1b gene ... long sequence found in a human gene (NTNG1). The related coronaviruses SARS-Cov had a 41 BP human ... CoV-2) sequence in the human genome with 94.6% identity. The sequence was in chromosome 1p ...

    Abstract In a previous study, we identified a 117 base severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequence in the human genome with 94.6% identity. The sequence was in chromosome 1p within an intronic region of the netrin G1 (NTNG1) gene. The sequence matched a sequence in the SARS-CoV-2 Orf1b gene in non-structural protein 14 (NSP14), which is an exonuclease and NSP15, an endoribonuclease. In the current study we compared the human genome with other viral genomes to determine some of the characteristics of human sequences found in the latter. Most of the viruses had human sequences, but they were short. Hepatitis A and St Louis encephalitis had human sequences that were longer than the 117 base SARS-Cov-2 sequence, but they were in non-coding regions of the human genome. The SARS-Cov-2 sequence was the only long sequence found in a human gene (NTNG1). The related coronaviruses SARS-Cov had a 41 BP human sequence on chromosome 3 that was not part of a human gene, and MERS had no human sequence. The 117 base SARS-CoV-2 human sequence is relatively close to the viral spike sequence, separated only by NSP16, a 904 base sequence. The mechanism for SARS-CoV-2 infection is the binding of the virus spike protein to the membrane-bound form of angiotensin-converting enzyme 2 (ACE2) and internalization of the complex by the host cell. We have no explanation for the NSP14 and NSP15 SARS-Cov-2 sequences we observed here or how they might relate to infectiousness. Further studies are warranted.
    MeSH term(s) Betacoronavirus/genetics ; Chromosomes, Human, Pair 1/genetics ; Chromosomes, Human, Pair 3/genetics ; DNA Viruses/genetics ; Endoribonucleases ; Exoribonucleases/genetics ; GPI-Linked Proteins/genetics ; Genome, Viral ; Humans ; Middle East Respiratory Syndrome Coronavirus/genetics ; Netrins/genetics ; SARS Virus/genetics ; SARS-CoV-2 ; Sequence Alignment ; Sequence Homology, Nucleic Acid ; Species Specificity ; Viral Nonstructural Proteins/genetics ; Viral Proteins/genetics
    Chemical Substances GPI-Linked Proteins ; NTNG1 protein, human ; Netrins ; Viral Nonstructural Proteins ; Viral Proteins ; Endoribonucleases (EC 3.1.-) ; Exoribonucleases (EC 3.1.-) ; NSP14 protein, SARS-CoV-2 (EC 3.1.-) ; nidoviral uridylate-specific endoribonuclease (EC 3.1.-)
    Keywords covid19
    Language English
    Publishing date 2020-05-29
    Publishing country Greece
    Document type Comparative Study ; Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.11954
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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