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  1. Article ; Online: Is the HScore useful in COVID-19?

    Leverenz, David L / Tarrant, Teresa K

    Lancet (London, England)

    2020  Volume 395, Issue 10236, Page(s) e83

    MeSH term(s) Betacoronavirus ; COVID-19 ; Calcinosis ; Coronavirus Infections ; Cytokines ; Heart Valve Diseases ; Humans ; Immune Tolerance ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-05-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)31057-6
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  3. Article ; Online: Is the HScore useful in COVID-19?

    Leverenz, David L / Tarrant, Teresa K

    The Lancet

    2020  Volume 395, Issue 10236, Page(s) e83

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(20)31057-6
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: An elevated HScore is associated with poor clinical outcomes in COVID-19.

    Benavente, Rafael / Peña, Camila / Cid, Allyson / Cabello, Nicolás / Bustamante, Pablo / Álvarez, Marco / Henríquez, Elizabeth / Soto, Andrés / Rubilar, Erika

    Revista medica de Chile

    2023  Volume 151, Issue 1, Page(s) 15–22

    Abstract: ... rartio 2.13, p = 0.022).: Conclusions: sHLH is not frequent among COVID-19 patients. HScore can be ... Background: Patients with Coronavirus Disease 2019 (COVID-19) frequently experience ... fibrinogen and AST was validated for sHLH, and recently proposed to evaluate hyperinflammation in COVID-19 ...

    Abstract Background: Patients with Coronavirus Disease 2019 (COVID-19) frequently experience a hyperinflammatory syndrome leading to unfavorable outcomes. This condition resembles Secondary Hemophagocytic Lymphohistiocytosis (sHLH) described in neoplastic, rheumatic and other infectious diseases. A scoring system (HScore) that evaluates underlying immunosuppression, temperature, organomegaly, cytopenias, ferritin, triglycerides, fibrinogen and AST was validated for sHLH, and recently proposed to evaluate hyperinflammation in COVID-19.
    Aim: To assess the presence of sHLH among patients with COVID-19 admitted for hospitalization and to evaluate Hscore as a prognostic tool for poor outcomes.
    Material and methods: One hundred forty-three patients aged 21-100 years (64% males) admitted because of COVID-19 were enrolled in a prospective study. HScore was calculated within 72 hours admission. The incidence of sHLH during hospitalization was evaluated. Additionally, the relationship between a HScore ≥ 130 points and either the requirement of mechanical ventilation or 60-days mortality was explored.
    Results: The median HScore was 96 (33-169). A SHLH was diagnosed in one patient (incidence 0.7%), whose HScore was 169. After adjusting for age, sex, comorbidities and obesity, HScore ≥ 130 was independently associated with the composite clinical outcome (Hazard rartio 2.13, p = 0.022).
    Conclusions: sHLH is not frequent among COVID-19 patients. HScore can be useful to predict the risk for poor outcomes.
    MeSH term(s) Male ; Humans ; Female ; COVID-19/complications ; Prospective Studies ; Lymphohistiocytosis, Hemophagocytic/etiology ; Comorbidity ; Hospitalization
    Language English
    Publishing date 2023-10-31
    Publishing country Chile
    Document type Journal Article
    ZDB-ID 732136-3
    ISSN 0717-6163 ; 0034-9887
    ISSN (online) 0717-6163
    ISSN 0034-9887
    DOI 10.4067/s0034-98872023000100015
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  5. Article ; Online: Secondary haemophagocytic lymphohistiocytosis in hospitalised COVID-19 patients as indicated by a modified HScore is infrequent and high scores do not associate with increased mortality.

    Ardern-Jones, Michael R / Stammers, Matt / Phan, Hang Tt / Borca, Florina / Koutalopoulou, Anastasia / Teo, Ying / Batchelor, James / Smith, Trevor / Duncombe, Andrew S

    Clinical medicine (London, England)

    2021  Volume 21, Issue 5, Page(s) e543–e547

    Abstract: A significant proportion of COVID-19 patients show evidence of hyperinflammation (HI ... the prevalence of sHLH in 567 COVID-19 inpatient cases.The overall incidence of individuals with an 80 ... probability of sHLH in our COVID-19 cohort was 1.59% on admission and only rose to 4.05% if calculated ...

    Abstract A significant proportion of COVID-19 patients show evidence of hyperinflammation (HI), of which secondary haemophagocytic lymphohistiocytosis (sHLH) is the most severe manifestation and diagnosed with HScore. Using a COVID-relevant modification of the HScore (%HScore), we set out to determine the prevalence of sHLH in 567 COVID-19 inpatient cases.The overall incidence of individuals with an 80% probability of sHLH in our COVID-19 cohort was 1.59% on admission and only rose to 4.05% if calculated at any time during admission. This small cohort as defined by %HScore showed no excess mortality compared with the whole cohort. Overall, %HScores were lower in older patients (p<0.0001) and did not reliably predict outcome at any cut-off value (AUROC 0.533, p=0.211, odds ratio 0.99).Our study demonstrates that a modified version (%HScore) of the conventional sHLH scoring system (HScore) does not enable risk stratification in people hospitalised with COVID. We propose further work is needed to develop novel approaches to predict HI and improve trial stratification for HI directed therapy in people with COVID-19.
    MeSH term(s) Aged ; COVID-19 ; Cohort Studies ; Humans ; Incidence ; Lymphohistiocytosis, Hemophagocytic/epidemiology ; SARS-CoV-2
    Language English
    Publishing date 2021-08-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmed.2021-0053
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