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Article ; Online: COVID-19 and the effects on pulmonary function following infection: A retrospective analysis.

Lewis, Kristyn L / Helgeson, Scott A / Tatari, Mehmet M / Mallea, Jorge M / Baig, Hassan Z / Patel, Neal M

EClinicalMedicine

2021 Volume 39, Page(s) 101079

Abstract: ... of pulmonary function tests obtained following COVID-19 infection.: Funding: No funding was obtained for this study. ... to compare pre-infection and post-infection pulmonary function tests (PFT) in COVID-19 infected patients ... a retrospective multi-center cohort study. Patients were identified based on having COVID-19 and a pre- and post ...

Abstract	Background: The coronavirus disease 2019 (COVID-19) has been identified in over 110 million people with no studies comparing pre-infection pulmonary function to post-infection. This study's aim was to compare pre-infection and post-infection pulmonary function tests (PFT) in COVID-19 infected patients to better delineate between preexisting abnormalities and effects of the virus. Methods: This was a retrospective multi-center cohort study. Patients were identified based on having COVID-19 and a pre- and post-infection PFT within one year of infection during the time period of March 1, 2020 to November 10, 2020. Findings: There was a total of 80 patients, with an even split in gender; the majority were white ( Interpretation: This study showed that there is no difference in pulmonary function as measured by PFT before and after COVID-19 infection in non-critically ill classified patients. There could be a relationship with certain underlying lung diseases (interstitial lung disease and cystic fibrosis) and decreased lung function following infection. This information should aid clinicians in their interpretation of pulmonary function tests obtained following COVID-19 infection. Funding: No funding was obtained for this study.
Language	English
Publishing date	2021-08-13
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2021.101079
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Right ventricular systolic dysfunction as a predictor of adverse outcome in patients with COVID-19].

Golukhova, E Z / Slivneva, I V / Rybka, M M / Mamalyga, M L / Marapov, D I / Klyuchnikov, I V / Antonova, D E / Dibin, D A

Kardiologiia

2020 Volume 60, Issue 11, Page(s) 1303

Abstract: ... stratification in patients with COVID-19, and help making clinical decisions for patients with different acute ... for evaluation of the right ventricular (RV) systolic function.Material and methods Data of patients were ... predictors for an unfavorable outcome, estimated pulmonary artery systolic pressure (EPASP) and maximal ...

Abstract	Aim To analyze survival of patients with COVID-19 based on echocardiographic (EchoCG) criteria for evaluation of the right ventricular (RV) systolic function.Material and methods Data of patients were retrospectively evaluated at the Center for Medical Care of Patients with Coronavirus Infection. Among 142 primarily evaluated patients with documented COVID-19, 110 patients (men/women, 63/47; mean age, 62.3 ± 15.3 years) met inclusion/exclusion criteria. More than 30 EchoCG parameters were analyzed, and baseline data (comorbidities, oxygen saturation, laboratory data, complications, outcomes, etc.) were evaluated. ROC-analysis was used for evaluating the diagnostic significance of different EchoCG parameters for prediction of a specific outcome and its probability. Dependence of the overall survival of patients on different EchoCG parameters was analyzed with the Cox proportional hazards model. For assessing the predictive value of EchoCG parameters for patient stratification by risk of an adverse outcome, a predictive model was developed using the CHAID method.Results The in-hospital death rate of patients included into the study was 15.5 %, and the death rate for this period of in-hospital observation was 12 %. Based on the single-factor analysis of EchoCG parameters, a multifactor model was developed using the method of Cox regression. The model included two predictors for an unfavorable outcome, estimated pulmonary artery systolic pressure (EPASP) and maximal indexed right atrial volume (RAi), and a preventive factor, right ventricular global longitudinal strain (LS RV). Base risks for fatal outcome were determined with an account of the follow-up time. According to the obtained values, an increase in EPASP by 1 mm Hg was associated with increases in the risk of fatal outcome by 8.6 % and in the RA(i) volume by 1 ml/5.8 %. LS RV demonstrated an inverse correlation; a 1% increase in LS RV was associated with a 13.4% decrease in the risk for an unfavorable outcome. According to the ROC analysis, the most significant determinants of the outcome were the tricuspid annular plane systolic excursion (TAPSE) (AUC, 0.84 ± 0.06; cut-off, 18 mm) and EPASP (AUC, 0.86 ± 0.05; cut-off, 42 mm Hg). Evaluating the effects of different EchoCG predictors, that characterized the condition of the right heart, provided a classification tree. Six final decisions were determined in the model, two of which were assigned to the category of reduced risk for fatal outcome and four were assigned to the category of increased risk. Sensitivity of the classification tree model was 94.1 % and specificity was 89.2 %. Overall diagnostic significance was 90.0±2.9 %.Conclusion The presented models for statistical treatment of EchoCG parameters reflect the requirement for a comprehensive analysis of EchoCG parameters based on a combination of standard methods for EchoCG evaluation and current technologies of noninvasive visualization. According to the study results, the new EchoCG marker, LS RV, allows identifying the signs of right ventricular dysfunction (particularly in combination with pulmonary hemodynamic indexes), may enhance the early risk stratification in patients with COVID-19, and help making clinical decisions for patients with different acute cardiorespiratory diseases.
MeSH term(s)	Aged ; COVID-19 ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; Ventricular Dysfunction, Right/diagnosis ; Ventricular Function, Right
Language	Russian
Publishing date	2020-12-15
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	131029-x
ISSN	0022-9040
ISSN	0022-9040
DOI	10.18087/cardio.2020.11.n1303
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Article ; Online: COVID-19 and the effects on pulmonary function following infection

Kristyn L. Lewis / Scott A. Helgeson / Mehmet M. Tatari / Jorge M. Mallea / Hassan Z. Baig / Neal M. Patel

EClinicalMedicine, Vol 39, Iss , Pp 101079- (2021)

A retrospective analysis

2021

Abstract: ... in pulmonary function as measured by PFT before and after COVID-19 infection in non-critically ill classified ... to compare pre-infection and post-infection pulmonary function tests (PFT) in COVID-19 infected patients ... a retrospective multi-center cohort study. Patients were identified based on having COVID-19 and a pre- and post ...

Abstract	Background: The coronavirus disease 2019 (COVID-19) has been identified in over 110 million people with no studies comparing pre-infection pulmonary function to post-infection. This study's aim was to compare pre-infection and post-infection pulmonary function tests (PFT) in COVID-19 infected patients to better delineate between preexisting abnormalities and effects of the virus. Methods: This was a retrospective multi-center cohort study. Patients were identified based on having COVID-19 and a pre- and post-infection PFT within one year of infection during the time period of March 1, 2020 to November 10, 2020. Findings: There was a total of 80 patients, with an even split in gender; the majority were white (n = 70, 87·5%) and never smokers (n = 42, 52·5%). The majority had mild to moderate COVID-19 disease (n = 60, 75·1%) with 25 (31·2%) requiring hospitalization. There was no difference between the pre- and post-PFT data, specifically with the forced vital capacity (FVC) (p = 0·52), forced expiratory volume in 1 s (FEV1)(p = 0·96), FEV1/FVC(p = 0·66), total lung capacity (TLC) (p = 0·21), and diffusion capacity (DLCO)(p = 0·88). There was no difference in the PFT when analyzed by hospitalization and disease severity. After adjusting for potential confounders, interstitial lung disease (ILD) was independently associated with a decreased FEV1 (-2·6 [95% CI, -6·7 to - 1·6] vs. -10·3 [95% CI, -17·7 to -2·9]; p = 0·03) and an increasing age (p = 0·01) and cystic fibrosis (-1·1 [95% CI, -4·5 to- 2·4] vs. -36·5 [95% CI, -52·1 to -21·0]; p < 0·01) were associated with decreasing FVC when comparing pre and post infection PFT. Only increasing age was independently associated with a reduction in TLC (p = 0·01) and DLCO (p = 0·02) before and after infection. Interpretation: This study showed that there is no difference in pulmonary function as measured by PFT before and after COVID-19 infection in non-critically ill classified patients. There could be a relationship with certain underlying lung diseases (interstitial ...
Keywords	COVID-19 ; Pulmonary function test ; Follow-up ; Respiratory ; outcomes ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Incidence, patterns, risk factors, and histopathological findings of liver injury in coronavirus disease 2019 (COVID-19): a scoping review.

Bin Arif, T / Khalid, S / Siddiqui, M S / Hussain, H / Sohail, H

Hong Kong medical journal = Xianggang yi xue za zhi

2020 Volume 27, Issue 1, Page(s) 198–209

Abstract: ... indicate that COVID-19 has direct cytopathic effects and causes liver function test derangements secondary ... to inflammation, hypoxia, and vascular insult.: Conclusions: Liver injury following COVID-19 infection is ... risk factors, histopathological findings, and relationship with disease severity of COVID-19-associated liver ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) exhibits many extrapulmonary manifestations, including liver injury. This scoping review aimed to provide insight into the incidence, patterns, risk factors, histopathological findings, and relationship with disease severity of COVID-19-associated liver injury. Furthermore, we identified existing gaps in the research on the hepatic manifestations of COVID-19 and highlighted areas for future investigations. Methods: A scoping review was conducted following the methodological framework suggested by Arksey and O'Mallay. Five online databases, along with grey literature, were searched for articles published until 22 May 2020, and we included 62 articles in the review. The research domains, methodological characteristics, and key conclusions were included in the analysis. Results: Retrospective observational studies comprised more than one third (41.9%) of the included publications, and 77.8% were conducted on living patients. The incidence of liver injury varied widely across the studies (4.8%-78%), and liver injury was frequently associated with severe COVID-19. We identified the following risk factors for liver injury: male sex, lymphopoenia, gastrointestinal involvement, old age, increased neutrophil count, and the use of hepatotoxic drugs. Histopathological findings indicate that COVID-19 has direct cytopathic effects and causes liver function test derangements secondary to inflammation, hypoxia, and vascular insult. Conclusions: Liver injury following COVID-19 infection is common and primarily hepatocellular, with a greater elevation of aspartate aminotransferase tahn of alanine aminotransferase. However, the evidence regarding hepatic failure secondary to COVID-19 is insufficient. Standardised criteria to diagnose liver injury need to be devised. Current use of hepatotoxic drugs necessitates close monitoring of liver function.
MeSH term(s)	COVID-19/complications ; COVID-19/epidemiology ; Humans ; Incidence ; Liver Diseases/epidemiology ; Liver Diseases/etiology ; Liver Diseases/pathology ; Liver Diseases/physiopathology ; Liver Function Tests/methods ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index
Keywords	covid19
Language	English
Publishing date	2020-10-30
Publishing country	China
Document type	Journal Article ; Systematic Review
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
DOI	10.12809/hkmj208732
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Article ; Online: Delayed surgery versus nonoperative treatment for hip fractures in post-COVID-19 arena: a retrospective study of 145 patients.

Mi, Bobin / Chen, Lang / Tong, Dake / Panayi, Adriana C / Ji, Fang / Guo, Junfei / Ou, Zhiyong / Zhang, Yingze / Xiong, Yuan / Liu, Guohui

Acta orthopaedica

2020 Volume 91, Issue 6, Page(s) 639–643

Abstract: Background and purpose - Following the outbreak of COVID-19 in December 2019, in China ... improves hip joint function and reduces major complications better than nonoperative therapy. Patients and ... compared with nonoperative therapy significantly improved hip function and reduced various major ...

Abstract	Background and purpose - Following the outbreak of COVID-19 in December 2019, in China, many hip fracture patients were unable to gain timely admission and surgery. We assessed whether delayed surgery improves hip joint function and reduces major complications better than nonoperative therapy. Patients and methods - In this retrospective observational study, we collected data from 24 different hospitals from January 1, 2020, to July 20, 2020. 145 patients with hip fractures aged 65 years or older were eligible. Clinical data was extracted from electronic medical records. The primary outcomes were visual analogue scale (VAS) score and Harris Hip Score. Major complications, including deep venous thrombosis (DVT) and pneumonia within 1 month and 3 months, were collected for further analysis. Results - Of the 145 hip fracture patients 108 (median age 72; 70 females) received delayed surgery and 37 (median age 74; 20 females) received nonoperative therapy. The median time from hip fracture injury to surgery was 33 days (IQR 24-48) in the delayed surgery group. Hypertension, in about half of the patients in both groups, and cerebral infarction, in around a quarter of patients in both groups, were the most common comorbidities. Both VAS score and Harris Hip Score were superior in the delayed surgery group. At the 3-month follow-up, the median VAS score was 1 in the delayed surgery group and 2.5 in the nonoperative group (p < 0.001). Also, the percentage of complications was higher in the nonoperative group (p = 0.004 for DVT, p < 0.001 for pulmonary infection). Interpretation - In hip fracture patients, delayed surgery compared with nonoperative therapy significantly improved hip function and reduced various major complications.
MeSH term(s)	Aged ; COVID-19/epidemiology ; COVID-19/prevention & control ; Cerebral Infarction/epidemiology ; Cerebral Infarction/etiology ; Cerebral Infarction/prevention & control ; China/epidemiology ; Conservative Treatment/adverse effects ; Conservative Treatment/methods ; Conservative Treatment/statistics & numerical data ; Electronic Health Records/statistics & numerical data ; Female ; Fracture Fixation/adverse effects ; Fracture Fixation/methods ; Fracture Fixation/statistics & numerical data ; Hip Fractures/epidemiology ; Hip Fractures/therapy ; Humans ; Hypertension/epidemiology ; Hypertension/etiology ; Hypertension/prevention & control ; Male ; Outcome and Process Assessment, Health Care ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; SARS-CoV-2 ; Time-to-Treatment/statistics & numerical data
Keywords	covid19
Language	English
Publishing date	2020-09-08
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2180677-9
ISSN	1745-3682 ; 1745-3674
ISSN (online)	1745-3682
ISSN	1745-3674
DOI	10.1080/17453674.2020.1816617
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Article: Incidence, patterns, risk factors, and histopathological findings of liver injury in coronavirus disease 2019 (COVID-19): a scoping review

Bin Arif, T / Khalid, S / Siddiqui, M S / Hussain, H / Sohail, H

Hong Kong med. j

Abstract: ... to inflammation, hypoxia, and vascular insult. CONCLUSIONS: Liver injury following COVID-19 infection is common ... 19 has direct cytopathic effects and causes liver function test derangements secondary ... 19 and highlighted areas for future investigations. METHODS: A scoping review was conducted following ...

Abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) exhibits many extrapulmonary manifestations, including liver injury. This scoping review aimed to provide insight into the incidence, patterns, risk factors, histopathological findings, and relationship with disease severity of COVID-19-associated liver injury. Furthermore, we identified existing gaps in the research on the hepatic manifestations of COVID-19 and highlighted areas for future investigations. METHODS: A scoping review was conducted following the methodological framework suggested by Arksey and O'Mallay. Five online databases, along with grey literature, were searched for articles published until 22 May 2020, and we included 62 articles in the review. The research domains, methodological characteristics, and key conclusions were included in the analysis. RESULTS: Retrospective observational studies comprised more than one third (41.9%) of the included publications, and 77.8% were conducted on living patients. The incidence of liver injury varied widely across the studies (4.8%-78%), and liver injury was frequently associated with severe COVID-19. We identified the following risk factors for liver injury: male sex, lymphopoenia, gastrointestinal involvement, old age, increased neutrophil count, and the use of hepatotoxic drugs. Histopathological findings indicate that COVID-19 has direct cytopathic effects and causes liver function test derangements secondary to inflammation, hypoxia, and vascular insult. CONCLUSIONS: Liver injury following COVID-19 infection is common and primarily hepatocellular, with a greater elevation of aspartate aminotransferase than of alanine aminotransferase. However, the evidence regarding hepatic failure secondary to COVID-19 is insufficient. Standardised criteria to diagnose liver injury need to be devised. Current use of hepatotoxic drugs necessitates close monitoring of liver function.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #895728
Database	COVID19

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Article: Clinical analysis of 2019 coronavirus disease (COVID-19) on one case with living-related kidney transplantation

LU, Xia / MING, Changsheng / WEN, Zhixiang / QIU, Liru / XU, Shuyun / CHEN, Tao / NING, Qin / LUO, Xiaoping / CHEN, Zhishui / GONG, Nianqiao

Chinese Journal of Organ Transplantation

Abstract: ... of COVID-19 in epidemiological investigation, clinical manifestation, examination, pulmonary imaging and ... infected with 2019 coronavirus disease (COVID-19) Method The clinical diagnosis and treatment of one ... 19 (severe type) with influenza A virus infection The clinical symptoms were gradually relieved and ...

Abstract	Objective To analyze the clinical characteristics of one living-related kidney transplant recipient infected with 2019 coronavirus disease (COVID-19) Method The clinical diagnosis and treatment of one relative renal transplant recipient after the occurrence of COVID-19 were analyzed retrospectively, including the course of onset, clinical manifestations, blood routine test, renal function, lung CT scan, nucleic acid detection, outpatient and inpatient therapies and outcomes Result The case was diagnosed as COVID-19 (severe type) with influenza A virus infection The clinical symptoms were gradually relieved and the lung lesions were absorbed through the treatment of reduce and stop taking immunosuppressant, antiviral therapy of abidol/oseltamivir, prevention of bacterial infection, hormone anti-inflammatory, oxygen inhalation, nutritional support and adequate rest Conclusion This case present typical characteristics of COVID-19 in epidemiological investigation, clinical manifestation, examination, pulmonary imaging and etiology After comprehensive treatment including reduce and stop immunosuppressive therapy, clinical cure was achieved The long-term effect of COVID-19 on this immunosuppressive patient remains follow-up
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #6561
Database	COVID19

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Article: Clinical analysis of 2019 coronavirus disease (COVID-19) on one case with living-related kidney transplantation/ 中华器官移植杂志

Xia, LU / MING, Changsheng / WEN, Zhixiang / QIU, Liru / Shuyun, XU / CHEN, Tao / NING, Qin / LUO, Xiaoping / CHEN, Zhishui / GONG, Nianqiao

Chinese Journal of Organ Transplantation

Abstract: ... recipient infected with 2019 coronavirus disease (COVID-19) .@*Method@#The clinical diagnosis and treatment ... characteristics of COVID-19 in epidemiological investigation, clinical manifestation, examination, pulmonary ... as COVID-19 (severe type) with influenza A virus infection. The clinical symptoms were gradually relieved ...

Abstract	Objective@#To analyze the clinical characteristics of one living-related kidney transplant recipient infected with 2019 coronavirus disease (COVID-19) .@Method@#The clinical diagnosis and treatment of one relative renal transplant recipient after the occurrence of COVID-19 were analyzed retrospectively, including the course of onset, clinical manifestations, blood routine test, renal function, lung CT scan, nucleic acid detection, outpatient and inpatient therapies and outcomes.@Result@#The case was diagnosed as COVID-19 (severe type) with influenza A virus infection. The clinical symptoms were gradually relieved and the lung lesions were absorbed through the treatment of reduce and stop taking immunosuppressant, antiviral therapy of abidol/oseltamivir, prevention of bacterial infection, hormone anti-inflammatory, oxygen inhalation, nutritional support and adequate rest.@*Conclusion@#This case present typical characteristics of COVID-19 in epidemiological investigation, clinical manifestation, examination, pulmonary imaging and etiology. After comprehensive treatment including reduce and stop immunosuppressive therapy, clinical cure was achieved. The long-term effect of COVID-19 on this immunosuppressive patient remains follow-up.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #6561
Database	COVID19

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Article ; Online: COVID-19 and the effects on pulmonary function following infection: A retrospective analysis.

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Article: [Right ventricular systolic dysfunction as a predictor of adverse outcome in patients with COVID-19].

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Article ; Online: COVID-19 and the effects on pulmonary function following infection

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Article: Incidence, patterns, risk factors, and histopathological findings of liver injury in coronavirus disease 2019 (COVID-19): a scoping review.

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Article ; Online: Delayed surgery versus nonoperative treatment for hip fractures in post-COVID-19 arena: a retrospective study of 145 patients.

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Article: Incidence, patterns, risk factors, and histopathological findings of liver injury in coronavirus disease 2019 (COVID-19): a scoping review

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Article: Clinical analysis of 2019 coronavirus disease (COVID-19) on one case with living-related kidney transplantation

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Article: Clinical analysis of 2019 coronavirus disease (COVID-19) on one case with living-related kidney transplantation/ 中华器官移植杂志

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