Article ; Online: Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection.
2017 Volume 8, Issue 2
Abstract: ... demonstrate that the absence of the P2X7 receptor results in a better outcome to influenza virus infection ... either as a protective response or as detrimental immunopathology, are not well understood. The purinergic receptor P2X7 ... An exacerbated immune response is one of the main causes of influenza-induced lung damage during ...
| Abstract | An exacerbated immune response is one of the main causes of influenza-induced lung damage during infection. The molecular mechanisms regulating the fate of the initial immune response to infection, either as a protective response or as detrimental immunopathology, are not well understood. The purinergic receptor P2X7 is an ionotropic nucleotide-gated ion channel receptor expressed on immune cells that has been implicated in induction and maintenance of excessive inflammation. Here, we analyze the role of this receptor in a mouse model of influenza virus infection using a receptor knockout (KO) mouse strain. Our results demonstrate that the absence of the P2X7 receptor results in a better outcome to influenza virus infection characterized by reduced weight loss and increased survival upon experimental influenza challenge compared to wild-type mice. This effect was not virus strain specific. Overall lung pathology and apoptosis were reduced in virus-infected KO mice. Production of proinflammatory cytokines and chemokines such as interleukin-10 (IL-10), gamma interferon (IFN-γ), and CC chemokine ligand 2 (CCL2) was also reduced in the lungs of the infected KO mice. Infiltration of neutrophils and depletion of CD11b |
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| MeSH term(s) | Animals ; Body Weight ; Cytokines/analysis ; Disease Models, Animal ; Host-Pathogen Interactions ; Lung/pathology ; Macrophages/immunology ; Mice ; Mice, Knockout ; Neutrophils/immunology ; Orthomyxoviridae/pathogenicity ; Orthomyxoviridae Infections/pathology ; Orthomyxoviridae Infections/virology ; Receptors, Purinergic P2X7/metabolism ; Survival Analysis |
| Chemical Substances | Cytokines ; Receptors, Purinergic P2X7 |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2017-03-28 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 2557172-2 |
| ISSN | 2150-7511 ; 2161-2129 |
| ISSN (online) | 2150-7511 |
| ISSN | 2161-2129 |
| DOI | 10.1128/mBio.00229-17 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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