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  1. Article ; Online: Characteristics of COVID-19 Infection in Patients without a History of Travel to Infected Areas or Direct Contact with a Case-Patient.

    Li, BinBin

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi

    2020  Volume 87, Issue 4, Page(s) 240–242

    Abstract: ... to infected areas or direct contact with a case-patient. Patients presented with various symptoms, increased ... Objective: Little is known about COVID-19 patients who have not traveled to infected areas or had ... direct contact with infected persons. This report describes the clinical features of 28 such patients ...

    Abstract Objective: Little is known about COVID-19 patients who have not traveled to infected areas or had direct contact with infected persons. This report describes the clinical features of 28 such patients with confirmed COVID-19 infection.
    Methods: Data on clinical characteristics during hospitalization were collected.
    Results: Epidemiological exposures were investigated among patients reporting no travel to infected areas or direct contact with a case-patient. Patients presented with various symptoms, increased levels of inflammatory markers, and consolidation or ground-glass opacification on computed tomography scans.
    Conclusions: The present report contributes critical information on the clinical presentation of COVID-19 patients without typical epidemiological exposures.
    MeSH term(s) Adult ; Aged ; Betacoronavirus/pathogenicity ; COVID-19 ; COVID-19 Testing ; China/epidemiology ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Female ; Hospitalization ; Host Microbial Interactions ; Humans ; Inflammation Mediators/blood ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Predictive Value of Tests ; Risk Factors ; SARS-CoV-2 ; Tomography, X-Ray Computed
    Chemical Substances Inflammation Mediators
    Keywords covid19
    Language English
    Publishing date 2020-09-09
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2091563-9
    ISSN 1347-3409 ; 1345-4676
    ISSN (online) 1347-3409
    ISSN 1345-4676
    DOI 10.1272/jnms.JNMS.2020_87-411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 620: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Characteristics of COVID-19 Infection in Patients without a History of Travel to Infected Areas or Direct Contact with a Case-Patient

    Li, BinBin

    J Nippon Med Sch

    Abstract: ... to infected areas or direct contact with a case-patient. Patients presented with various symptoms, increased ... OBJECTIVE: Little is known about COVID-19 patients who have not traveled to infected areas or had ... direct contact with infected persons. This report describes the clinical features of 28 such patients ...

    Abstract OBJECTIVE: Little is known about COVID-19 patients who have not traveled to infected areas or had direct contact with infected persons. This report describes the clinical features of 28 such patients with confirmed COVID-19 infection. METHODS: Data on clinical characteristics during hospitalization were collected. RESULTS: Epidemiological exposures were investigated among patients reporting no travel to infected areas or direct contact with a case-patient. Patients presented with various symptoms, increased levels of inflammatory markers, and consolidation or ground-glass opacification on computed tomography scans. CONCLUSIONS: The present report contributes critical information on the clinical presentation of COVID-19 patients without typical epidemiological exposures.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #751077
    Database COVID19

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  3. Article ; Online: Epidemiological and clinical characteristics of discharged patients infected with SARS-CoV-2 on the Qinghai Plateau.

    Xi, Aiqi / Zhuo, Ma / Dai, Jingtao / Ding, Yuehe / Ma, Xiuzhen / Ma, Xiaoli / Wang, Xiaoyi / Shi, Lianmeng / Bai, Huanying / Zheng, Hongying / Nuermberger, Eric / Xu, Jian

    Journal of medical virology

    2020  Volume 92, Issue 11, Page(s) 2528–2535

    Abstract: ... four transmission clusters were identified. Three patients were infected by direct contact ... without travel history to Wuhan. Of 18 patients, 10 patients showed bilateral pneumonia and two patients showed ... sustained local transmission. Of all 18 patients with confirmed SARS-CoV-2 infection, 15 patients comprising ...

    Abstract Since the outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, a series of confirmed cases of COVID-19 were found on the Qinghai-Tibet plateau. We aimed to describe the epidemiological, clinical characteristics, and outcomes of all confirmed cases in Qinghai, a province at high altitude. The region had no sustained local transmission. Of all 18 patients with confirmed SARS-CoV-2 infection, 15 patients comprising four transmission clusters were identified. Three patients were infected by direct contact without travel history to Wuhan. Of 18 patients, 10 patients showed bilateral pneumonia and two patients showed no abnormalities. Three patients with comorbidities such as hypertension, liver diseases, or diabetes developed severe illness. High C-reactive protein levels and elevations of both alanine aminotransferase and aspartate aminotransferase were observed in three severely ill patients on admission. All 18 patients were eventually discharged, including the three severe patients who recovered after treatment with noninvasive mechanical ventilation, convalescent plasma, and other therapies. Our findings confirmed human-to-human transmission of SARS-CoV-2 in clusters. Patients with comorbidities are more likely to develop severe illness.
    MeSH term(s) Adolescent ; Adult ; COVID-19/epidemiology ; COVID-19/physiopathology ; COVID-19/transmission ; Child ; China/epidemiology ; Comorbidity ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Patient Discharge/statistics & numerical data ; Retrospective Studies ; Tibet/epidemiology ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Epidemiological and clinical characteristics of fifty-six cases of COVID-19 in Liaoning Province, China.

    Wang, Jing-Bo / Wang, Hai-Tao / Wang, Lei-Shi / Li, Lu-Ping / Xv, Jiao / Xv, Chun / Li, Xing-Hai / Wu, Yun-Hai / Liu, Hong-Yan / Li, Bai-Jun / Yu, Hong / Tian, Xia / Zhang, Zhi-Yu / Wang, Yan / Zhao, Rui / Liu, Jin-Yang / Wang, Wei / Gu, Ye

    World journal of clinical cases

    2020  Volume 8, Issue 21, Page(s) 5188–5202

    Abstract: ... in or traveled to Wuhan, 27 cases (48.2%) had been in contact with confirmed COVID-19 patients, 5 cases ... 8.9%) had been in contact with confirmed patients with a contact history to COVID-19 patients, and 1 ... No patient had been in direct contact with wild animals. Among them, 23 patients (41.1%) had resided ...

    Abstract Background: Pneumonia of uncertain cause has been reported in Wuhan, China since the beginning of early December 2019. In early January 2020, a novel strain of β-coronavirus was identified by the Chinese Center for Disease Control and Prevention from the pharyngeal swab specimens of patients, which was recently named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There is evidence of human-to-human transmission and familial cluster outbreak of SARS-CoV-2 infection. The World Health Organization(WHO) recently declared the SARS-CoV-2 epidemic a global health emergency. As of February 17, 2020, 71329 laboratory-confirmed cases (in 25 countries, including the United States and Germany) have been reported globally. Other than its rapid transmission, the epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) remain unclear. In December 2019, coronavirus disease (named COVID-19 by the WHO) associated with the SARS-CoV-2 emerged in Wuhan, China and spread quickly across the country.
    Aim: To analyze the epidemiological and clinical characteristics of confirmed cases of this disease in Liaoning province, a Chinese region about 1800 km north of Wuhan.
    Methods: The clinical data of 56 laboratory-confirmed COVID-19 cases due to 2019-nCoV infection were analyzed. The cases originated from eight cities in Liaoning province.
    Results: The median age of the patients was 45 years, and 57.1% of them were male. No patient had been in direct contact with wild animals. Among them, 23 patients (41.1%) had resided in or traveled to Wuhan, 27 cases (48.2%) had been in contact with confirmed COVID-19 patients, 5 cases (8.9%) had been in contact with confirmed patients with a contact history to COVID-19 patients, and 1 case (1.8%) had no apparent history of exposure. Fever (75.0%) and cough (60.7%) were the most common symptoms. The typical manifestations in lung computed tomography (CT) included ground-glass opacity and patchy shadows, with 67.8% of them being bilateral. Among the patients in the cohort, 78.6% showed reduction in their lymphocyte counts, 57.1% showed increases in their C-reactive protein levels, and 50.0% showed decreases in their blood albumin levels. Eleven patients (19.6%) were admitted to intensive care unit, 2 patients (3.5%) progressed to acute respiratory distress syndrome, 4 patients (7.1%) were equipped with non-invasive mechanical ventilation, and 1 patient (1.8) received extracorporeal membrane oxygenation support. There were 5 mild cases (5/56, 8.9%), 40 moderate cases (40/56, 71.4%), 10 severe cases (10/56, 17.9%), and 1 critical case (1/56, 1.8%). No deaths were reported.
    Conclusion: SARS-CoV-2 can be transmitted among humans. Most COVID-19 patients show symptoms of fever, cough, lymphocyte reduction, and typical lung CT manifestations. Most are moderate cases. The seriousness of the disease (as indicated by blood oxygen saturation, respiratory rate, oxygenation index, blood lymphocyte count, and lesions shown in lung CT) is related to history of living in or traveling to Wuhan, underlying diseases, admittance to intensive care unit, and mechanical ventilation.
    Language English
    Publishing date 2020-11-27
    Publishing country United States
    Document type Journal Article
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v8.i21.5188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Epidemiological and clinical characteristics of discharged patients infected with SARS-CoV-2 on the Qinghai plateau

    Xi, AIqi / Ma, Zhuo / Dai, Jingtao / Ding, Yuehe / Ma, Xiuzhen / Ma, Xiaoli / Wang, Xiaoyi / Shi, Lianmeng / Bai, Huanying / Zheng, Hongying / Nuermberger, Eric / Xu, Jian

    Abstract: ... patients comprising 4 transmission clusters were identified. Three patients were infected by direct contact ... without travel history to Wuhan. Seven patients were asymptomatic on admission. Of 18 patients, 10 patients ... important to prevent the spread of COVID-19 and improve the cure rate. Patients with comorbidities are more ...

    Abstract Since the outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, a series of confirmed cases of COVID-19 were found on the Qinghai-Tibet plateau. We aimed to describe the epidemiological, clinical characteristics, and outcomes of all confirmed cases in Qinghai, a province at high altitude. With efficient measures to stop the spread of coronavirus, no new cases were found in Qinghai Province for 60 consecutive days between Feb 6 and April 6, 2020. Of all 18 patients with confirmed SARS-CoV-2 infection, 15 patients comprising 4 transmission clusters were identified. Three patients were infected by direct contact without travel history to Wuhan. Seven patients were asymptomatic on admission. Of 18 patients, 10 patients showed bilateral pneumonia and 2 patients showed no abnormalities. Three patients with comorbidities such as hypertension, liver diseases or diabetes developed severe illness. High C-reactive protein levels and elevations of both ALT and AST were observed in 3 severely ill patients on admission. All 18 patients were eventually discharged, including the 3 severe patients who recovered after treatment with non-invasive mechanical ventilation, convalescent plasma and other therapies. Our findings confirmed human-to-human transmission of SARS-CoV-2 in clusters. The strategies of early diagnosis, early isolation, and early treatment are important to prevent the spread of COVID-19 and improve the cure rate. Patients with comorbidities are more likely to develop severe illness and could benefit from convalescent plasma transfusion.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    DOI 10.1101/2020.04.23.20077644
    Database COVID19

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  6. Article ; Online: Epidemiological and clinical characteristics of discharged patients infected with SARS-CoV-2 on the Qinghai plateau

    Xi, AIqi / Ma, Zhuo / Dai, Jingtao / Ding, Yuehe / Ma, Xiuzhen / Ma, Xiaoli / Wang, Xiaoyi / Shi, Lianmeng / Bai, Huanying / Zheng, Hongying / Nuermberger, Eric / Xu, Jian

    medRxiv

    Abstract: ... patients comprising 4 transmission clusters were identified. Three patients were infected by direct contact ... without travel history to Wuhan. Seven patients were asymptomatic on admission. Of 18 patients, 10 patients ... important to prevent the spread of COVID-19 and improve the cure rate. Patients with comorbidities are more ...

    Abstract Since the outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, a series of confirmed cases of COVID-19 were found on the Qinghai-Tibet plateau. We aimed to describe the epidemiological, clinical characteristics, and outcomes of all confirmed cases in Qinghai, a province at high altitude. With efficient measures to stop the spread of coronavirus, no new cases were found in Qinghai Province for 60 consecutive days between Feb 6 and April 6, 2020. Of all 18 patients with confirmed SARS-CoV-2 infection, 15 patients comprising 4 transmission clusters were identified. Three patients were infected by direct contact without travel history to Wuhan. Seven patients were asymptomatic on admission. Of 18 patients, 10 patients showed bilateral pneumonia and 2 patients showed no abnormalities. Three patients with comorbidities such as hypertension, liver diseases or diabetes developed severe illness. High C-reactive protein levels and elevations of both ALT and AST were observed in 3 severely ill patients on admission. All 18 patients were eventually discharged, including the 3 severe patients who recovered after treatment with non-invasive mechanical ventilation, convalescent plasma and other therapies. Our findings confirmed human-to-human transmission of SARS-CoV-2 in clusters. The strategies of early diagnosis, early isolation, and early treatment are important to prevent the spread of COVID-19 and improve the cure rate. Patients with comorbidities are more likely to develop severe illness and could benefit from convalescent plasma transfusion.
    Keywords covid19
    Language English
    Publishing date 2020-04-29
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.04.23.20077644
    Database COVID19

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  7. Article: Epidemiological and clinical characteristics of discharged patients infected with SARS-CoV-2 on the Qinghai Plateau

    Xi, Aiqi / Zhuo, Ma / Dai, Jingtao / Ding, Yuehe / Ma, Xiuzhen / Ma, Xiaoli / Wang, Xiaoyi / Shi, Lianmeng / Bai, Huanying / Zheng, Hongying / Nuermberger, Eric / Xu, Jian

    J. med. virol

    Abstract: ... four transmission clusters were identified. Three patients were infected by direct contact ... without travel history to Wuhan. Of 18 patients, 10 patients showed bilateral pneumonia and two patients showed ... sustained local transmission. Of all 18 patients with confirmed SARS-CoV-2 infection, 15 patients comprising ...

    Abstract Since the outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, a series of confirmed cases of COVID-19 were found on the Qinghai-Tibet plateau. We aimed to describe the epidemiological, clinical characteristics, and outcomes of all confirmed cases in Qinghai, a province at high altitude. The region had no sustained local transmission. Of all 18 patients with confirmed SARS-CoV-2 infection, 15 patients comprising four transmission clusters were identified. Three patients were infected by direct contact without travel history to Wuhan. Of 18 patients, 10 patients showed bilateral pneumonia and two patients showed no abnormalities. Three patients with comorbidities such as hypertension, liver diseases, or diabetes developed severe illness. High C-reactive protein levels and elevations of both alanine aminotransferase and aspartate aminotransferase were observed in three severely ill patients on admission. All 18 patients were eventually discharged, including the three severe patients who recovered after treatment with noninvasive mechanical ventilation, convalescent plasma, and other therapies. Our findings confirmed human-to-human transmission of SARS-CoV-2 in clusters. Patients with comorbidities are more likely to develop severe illness.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #326885
    Database COVID19

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