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  1. Article: Chronic Active Hepatitis B with COVID-19 in Pregnancy: A Case Report.

    Li, Qiu-Yu / An, Zhuo-Yu / Li, Chao / Zu, Ming / Chen, Lei / Zhang, Jia-Nan / Zhao, Yang-Yu / Shen, Ning / Ge, Qing-Gang

    Journal of clinical and translational hepatology

    2021  Volume 9, Issue 1, Page(s) 133–135

    Abstract: ... in patients with underlying diseases. In this case report, we present a case of chronic active hepatitis B ... with chronic active hepatitis B, and tested positive for SARS-CoV-2 infection. In this case, we applied liver protective and ... woman suffering from chronic active hepatitis B combined with COVID-19. ...

    Abstract Currently, infection with coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), during pregnancy is a problem worthy of attention, especially in patients with underlying diseases. In this case report, we present a case of chronic active hepatitis B with COVID-19 in pregnancy. A 31-year-old woman at 29 weeks of gestation who had a history of chronic hepatitis B virus infection discontinued antiviral treatment, was admitted to the hospital with chronic active hepatitis B, and tested positive for SARS-CoV-2 infection. In this case, we applied liver protective and antiviral agents, and low-dose dexamethasone therapy to successfully treat the critically ill pregnant woman suffering from chronic active hepatitis B combined with COVID-19.
    Language English
    Publishing date 2021-01-19
    Publishing country China
    Document type Case Reports
    ZDB-ID 3019822-7
    ISSN 2310-8819 ; 2225-0719
    ISSN (online) 2310-8819
    ISSN 2225-0719
    DOI 10.14218/JCTH.2020.00085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Massive Perivillous Fibrin Deposition and Chronic Histiocytic Intervillositis a Complication of SARS-CoV-2 Infection.

    Marton, T / Hargitai, B / Hunter, K / Pugh, M / Murray, P

    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

    2021  Volume 24, Issue 5, Page(s) 450–454

    Abstract: An emerging complication of COVID-19 (SARS-CoV-2) infection is reported. A 23-year-old patient ... maternal COVID-19 infection. Ultrasound examination confirmed intrauterine death. Placenta histology showed ... histiocytic intervillositis. Covid-19 infection is associated with similar pattern of histological changes ...

    Abstract An emerging complication of COVID-19 (SARS-CoV-2) infection is reported. A 23-year-old patient presented with high temperature and reduced fetal movements at 25 + 5/40 weeks of gestation. RT-PCR proved maternal COVID-19 infection. Ultrasound examination confirmed intrauterine death. Placenta histology showed necrosis of the villous trophoblast, associated with Chronic Histiocytic Intervillositis (CHI) and Massive Perivillous Fibrin Deposition (MPFD) with up to 90% - of the intervillous spaces being involved. Immunohistochemistry showed CD68 positive histiocytes in the intervillous spaces and the villous trophoblast was positive for the COVID-19 spike protein. RNA scope signal was indicative of the presence of the viral genome and active viral replication in the villous trophoblastic cells, respectively. MPFD is a gradually developing end-stage disease with various etiology, including autoimmune and alloimmune maternal response to antigens expressed at the feto-maternal interface and frequently accompanies chronic alloimmune villitis or histiocytic intervillositis. Covid-19 infection is associated with similar pattern of histological changes of the placenta leading to placental insufficiency and fetal death. This case report supports maternal- fetal vertical transmission of SARS-CoV-2 virus leading to placental insufficiency and fetal demise. MPFD and CHI appear to be the typical placental histology for SARS-CoV-2 virus infection associated fetal demise.
    MeSH term(s) Adult ; COVID-19/virology ; Chorionic Villi/pathology ; Chorionic Villi/virology ; Female ; Fetal Death/etiology ; Fibrin/metabolism ; Histiocytes/virology ; Humans ; Placenta/pathology ; Placenta/virology ; Pregnancy ; Pregnancy Complications, Infectious/pathology ; Pregnancy Complications, Infectious/virology ; RNA, Viral ; SARS-CoV-2/pathogenicity
    Chemical Substances RNA, Viral ; Fibrin (9001-31-4)
    Language English
    Publishing date 2021-06-03
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1463498-3
    ISSN 1615-5742 ; 1093-5266
    ISSN (online) 1615-5742
    ISSN 1093-5266
    DOI 10.1177/10935266211020723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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