Artikel ; Online: Modifiable lifestyle factors and severe COVID-19 risk: a Mendelian randomisation study.
2021 Band 14, Heft 1, Seite(n) 38
Abstract: ... of COVID-19 severe illness. This study highlights the importance of maintaining a healthy lifestyle ... lifetime smoking were associated with about two-fold increased risks of severe respiratory COVID-19 and ... with increased risk of COVID-19 severe illness or related death. However, whether these relationships are causal ...
| Abstract | Background: Lifestyle factors including obesity and smoking are suggested to be correlated with increased risk of COVID-19 severe illness or related death. However, whether these relationships are causal is not well known; neither for the relationships between COVID-19 severe illness and other common lifestyle factors, such as physical activity and alcohol consumption. Methods: Genome-wide significant genetic variants associated with body mass index (BMI), lifetime smoking, physical activity and alcohol consumption identified by large-scale genome-wide association studies (GWAS) of up to 941,280 individuals were selected as instrumental variables. Summary statistics of the genetic variants on severe illness of COVID-19 were obtained from GWAS analyses of up to 6492 cases and 1,012,809 controls. Two-sample Mendelian randomisation analyses were conducted. Results: Both per-standard deviation (SD) increase in genetically predicted BMI and lifetime smoking were associated with about two-fold increased risks of severe respiratory COVID-19 and COVID-19 hospitalization (all P < 0.05). Per-SD increase in genetically predicted physical activity was associated with decreased risks of severe respiratory COVID-19 (odds ratio [OR] = 0.19; 95% confidence interval [CI], 0.05, 0.74; P = 0.02), but not with COVID-19 hospitalization (OR = 0.44; 95% CI 0.18, 1.07; P = 0.07). No evidence of association was found for genetically predicted alcohol consumption. Similar results were found across robust Mendelian randomisation methods. Conclusions: Evidence is found that BMI and smoking causally increase and physical activity might causally decrease the risk of COVID-19 severe illness. This study highlights the importance of maintaining a healthy lifestyle in protecting from COVID-19 severe illness and its public health value in fighting against COVID-19 pandemic. |
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| Mesh-Begriff(e) | Alcohol Drinking ; Body Mass Index ; COVID-19/diagnosis ; COVID-19/genetics ; COVID-19/virology ; Exercise ; Genetic Variation ; Genome-Wide Association Study ; Humans ; Life Style ; Linkage Disequilibrium ; Mendelian Randomization Analysis/methods ; Odds Ratio ; Risk Factors ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; Smoking |
| Sprache | Englisch |
| Erscheinungsdatum | 2021-02-03 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2411865-5 |
| ISSN | 1755-8794 ; 1755-8794 |
| ISSN (online) | 1755-8794 |
| ISSN | 1755-8794 |
| DOI | 10.1186/s12920-021-00887-1 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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