LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article ; Online: Nanomedicine engulfed by macrophages for targeted tumor therapy.

    Li, Siwen / Feng, Song / Ding, Li / Liu, Yuxi / Zhu, Qiuyun / Qian, Zhiyu / Gu, Yueqing

    International journal of nanomedicine

    2016  Volume 11, Page(s) 4107–4124

    Abstract: ... the drug cytotoxicity to the cell vehicle have limited the application of macrophages in tumor therapy ... a promising pharmaceutical preparation for tumor-targeted therapy. ... such as doxorubicin and PTX. Interestingly, macrophages displayed stronger targeting ability to the tumor site ...

    Abstract Macrophages, exhibiting high intrinsic accumulation and infiltration into tumor tissues, are a novel drug vehicle for directional drug delivery. However, the low drug-loading (DL) capacity and the drug cytotoxicity to the cell vehicle have limited the application of macrophages in tumor therapy. In this study, different drugs involving small molecular and nanoparticle drugs were loaded into intrinsic macrophages to find a better way to overcome these limitations. Their DL capacity and cytotoxicity to the macrophages were first compared. Furthermore, their phagocytic ratio, dynamic distributions, and tumoricidal effects were also investigated. Results indicated that more lipid-soluble molecules and DL particles can be phagocytized by macrophages than hydrophilic ones. In addition, the N-succinyl-N'-octyl chitosan (SOC) DL particles showed low cytotoxicity to the macrophage itself, while the dynamic biodistribution of macrophages engulfed with different particles/small molecules showed similar profiles, mainly excreted from liver to intestine pathway. Furthermore, macrophages loaded with SOC-paclitaxel (PTX) particles exhibited greater therapeutic efficacies than those of macrophages directly carrying small molecular drugs such as doxorubicin and PTX. Interestingly, macrophages displayed stronger targeting ability to the tumor site hypersecreting chemokine in immunocompetent mice in comparison to the tumor site secreting low levels of chemokine in immunodeficiency mice. Finally, results demonstrated that macrophages carrying SOC-PTX are a promising pharmaceutical preparation for tumor-targeted therapy.
    MeSH term(s) Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents, Phytogenic/administration & dosage ; Cell Line, Tumor ; Chemokines/metabolism ; Chitosan/chemistry ; Doxorubicin/administration & dosage ; Drug Carriers/therapeutic use ; Humans ; Lipids/chemistry ; MCF-7 Cells ; Macrophages/cytology ; Macrophages/drug effects ; Mice ; Mice, Nude ; Micelles ; Nanoparticles/administration & dosage ; Paclitaxel/administration & dosage ; RAW 264.7 Cells ; Tissue Distribution
    Chemical Substances Antineoplastic Agents ; Antineoplastic Agents, Phytogenic ; Chemokines ; Drug Carriers ; Lipids ; Micelles ; N-succinyl-chitosan ; Doxorubicin (80168379AG) ; Chitosan (9012-76-4) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2016
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2364941-0
    ISSN 1178-2013 ; 1176-9114
    ISSN (online) 1178-2013
    ISSN 1176-9114
    DOI 10.2147/IJN.S110146
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6606: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Nanomedicine engulfed by macrophages for targeted tumor therapy

    Li S / Feng S / Ding L / Liu Y / Zhu Q / Qian Z / Gu Y

    International Journal of Nanomedicine, Vol Volume 11, Pp 4107-

    2016  Volume 4124

    Abstract: ... that macrophages carrying SOC–PTX are a promising pharmaceutical preparation for tumor-targeted therapy. Keywords ... of macrophages in tumor therapy. In this study, different drugs involving small molecular and nanoparticle drugs ... itself, while the dynamic biodistribution of macrophages engulfed with different particles/small molecules showed similar ...

    Abstract Siwen Li,1,* Song Feng,1,* Li Ding,1 Yuxi Liu,1 Qiuyun Zhu,1 Zhiyu Qian,2 Yueqing Gu1 1Department of Biomedical Engineering, China Pharmaceutical University, 2Department of Biomedical Engineering, School of Automation, Nanjing University of Aeronautics and Astronautics, Nanjing, Jiangsu, People’s Republic of China *These authors contributed equally tothis work Abstract: Macrophages, exhibiting high intrinsic accumulation and infiltration into tumor tissues, are a novel drug vehicle for directional drug delivery. However, the low drug-loading (DL) capacity and the drug cytotoxicity to the cell vehicle have limited the application of macrophages in tumor therapy. In this study, different drugs involving small molecular and nanoparticle drugs were loaded into intrinsic macrophages to find a better way to overcome these limitations. Their DL capacity and cytotoxicity to the macrophages were first compared. Furthermore, their phagocytic ratio, dynamic distributions, and tumoricidal effects were also investigated. Results indicated that more lipid-soluble molecules and DL particles can be phagocytized by macrophages than hydrophilic ones. In addition, the N-succinyl-N'-octyl chitosan (SOC) DL particles showed low cytotoxicity to the macrophage itself, while the dynamic biodistribution of macrophages engulfed with different particles/small molecules showed similar profiles, mainly excreted from liver to intestine pathway. Furthermore, macrophages loaded with SOC–paclitaxel (PTX) particles exhibited greater therapeutic efficacies than those of macrophages directly carrying small molecular drugs such as doxorubicin and PTX. Interestingly, macrophages displayed stronger targeting ability to the tumor site hypersecreting chemokine in immunocompetent mice in comparison to the tumor site secreting low levels of chemokine in immunodeficiency mice. Finally, results demonstrated that macrophages carrying SOC–PTX are a promising pharmaceutical preparation for tumor-targeted therapy. Keywords: macrophage, drug-loading capacity, ...
    Keywords macrophage ; drug capacity ; SOC-PTX ; tumor targeted therapy ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2016-08-01T00:00:00Z
    Publisher Dove Medical Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Macrophage-Mediated Tumor Cell Phagocytosis: Opportunity for Nanomedicine Intervention.

    Zhou, Xuefei / Liu, Xiangrui / Huang, Leaf

    Advanced functional materials

    2020  Volume 31, Issue 5

    Abstract: ... critical roles in mediating tumor immunity. As important innate immune cells, macrophages possess ... Nevertheless, live tumor cells have evolved to evade phagocytosis by macrophages via the extensive expression of anti ... Macrophages are one of the most abundant non-malignant cells in the tumor microenvironment, playing ...

    Abstract Macrophages are one of the most abundant non-malignant cells in the tumor microenvironment, playing critical roles in mediating tumor immunity. As important innate immune cells, macrophages possess the potential to engulf tumor cells and present tumor-specific antigens for adaptive antitumor immunity induction, leading to growing interest in targeting macrophage phagocytosis for cancer immunotherapy. Nevertheless, live tumor cells have evolved to evade phagocytosis by macrophages via the extensive expression of anti-phagocytic molecules, such as CD47. In addition, macrophages also rapidly recognize and engulf apoptotic cells (efferocytosis) in the tumor microenvironment, which inhibits inflammatory responses and facilitates immune escape of tumor cells. Thus, intervention of macrophage phagocytosis by blocking anti-phagocytic signals on live tumor cells or inhibiting tumor efferocytosis presents a promising strategy for the development of cancer immunotherapies. Here, the regulation of macrophage-mediated tumor cell phagocytosis is first summarized, followed by an overview of strategies targeting macrophage phagocytosis for the development of antitumor therapies. Given the potential off-target effects associated with the administration of traditional therapeutics (for example, monoclonal antibodies, small molecule inhibitors), we highlight the opportunity for nanomedicine in macrophage phagocytosis intervention.
    Language English
    Publishing date 2020-11-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2039420-2
    ISSN 1616-3028 ; 1616-301X
    ISSN (online) 1616-3028
    ISSN 1616-301X
    DOI 10.1002/adfm.202006220
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top