Article ; Online: Antiviral activity of interleukin-11 as a response to porcine epidemic diarrhea virus infection.
2019 Volume 50, Issue 1, Page(s) 111
Abstract: ... in Vero cells and the jejunum of piglets during porcine epidemic diarrhea virus (PEDV) infection, while IL-11 ... with recombinant porcine IL-11 (pIL-11) was found to suppress PEDV replication in Vero E6 cells, while IL-11 ... The potential of IL-11 to be used as a novel therapeutic against devastating viral diarrhea in piglets deserves ...
| Abstract | Interleukin-11 (IL-11), a well-known anti-inflammatory factor, provides protection from intestinal epithelium damage caused by physical or chemical factors. However, little is known of the role of IL-11 during viral infections. In this study, IL-11 expression at mRNA and protein levels were found to be high in Vero cells and the jejunum of piglets during porcine epidemic diarrhea virus (PEDV) infection, while IL-11 expression was found to be positively correlated with the level of viral infection. Pretreatment with recombinant porcine IL-11 (pIL-11) was found to suppress PEDV replication in Vero E6 cells, while IL-11 knockdown promoted viral infection. Furthermore, pIL-11 was found to inhibit viral infection by preventing PEDV-mediated apoptosis of cells by activating the IL-11/STAT3 signaling pathway. Conversely, application of a STAT3 phosphorylation inhibitor significantly antagonized the anti-apoptosis function of pIL-11 and counteracted its inhibition of PEDV. Our data suggest that IL-11 is a newfound PEDV-inducible cytokine, and its production enhances the anti-apoptosis ability of epithelial cells against PEDV infection. The potential of IL-11 to be used as a novel therapeutic against devastating viral diarrhea in piglets deserves more attention and study. |
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| MeSH term(s) | Animals ; Antiviral Agents ; Apoptosis ; Chlorocebus aethiops ; Cloning, Molecular ; Coronavirus Infections/metabolism ; Coronavirus Infections/veterinary ; Coronavirus Infections/virology ; Gene Expression Regulation/immunology ; Interleukin-11/genetics ; Interleukin-11/metabolism ; Porcine epidemic diarrhea virus ; Receptors, Interleukin-11/genetics ; Receptors, Interleukin-11/metabolism ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Swine ; Swine Diseases/immunology ; Swine Diseases/metabolism ; Swine Diseases/virology ; Vero Cells |
| Chemical Substances | Antiviral Agents ; Interleukin-11 ; Receptors, Interleukin-11 ; STAT3 Transcription Factor |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2019-12-21 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1146298-x |
| ISSN | 1297-9716 ; 0928-4249 |
| ISSN (online) | 1297-9716 |
| ISSN | 0928-4249 |
| DOI | 10.1186/s13567-019-0729-9 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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