Article ; Online: IFN-γ modulates Ly-49 receptors on NK cells in IFN-γ-induced pregnancy failure.
2015 Volume 5, Page(s) 18159
Abstract: ... that IFN-γ also modulates Ly-49 receptors on NK cells during pregnancy failure. The percentages of Ly-49A ... effects of IFN-γ with its role in regulating NK cell Ly-49 receptors during pregnancy failure. ... our data indicate that IFN-γ can modulate Ly-49 receptors on NK cells and this process may play a role ...
| Abstract | We have previously shown that interferon gamma (IFN-γ) induces aberrant CD49b(+) natural killer (NK) cell recruitment by regulating CX3CL1 and eventually provokes foetal loss. In this study, we show that IFN-γ also modulates Ly-49 receptors on NK cells during pregnancy failure. The percentages of Ly-49A(+) and Ly-49G2(+) NK cells in the uteri of the IFN-γ-treated group were significantly lower than those observed in the control group. Moreover, the median fluorescence intensity (MFI) values of Ly-49A and Ly-49G2 expression on NK cells in the uteri of the IFN-γ-treated group were significantly lower than those of the control group. Using isolated spleen leucocytes, we further found that IFN-γ significantly reduced the percentage of Ly-49A(+) NK cells in vitro. However, CX3CL1 was not involved in the modulation of Ly-49 receptors, and the expression of CX3CR1 was not regulated by IFN-γ in spleen leucocytes. Collectively, our data indicate that IFN-γ can modulate Ly-49 receptors on NK cells and this process may play a role in IFN-γ-induced pregnancy failure. Thus, we provide a new line of evidence correlating the deleterious effects of IFN-γ with its role in regulating NK cell Ly-49 receptors during pregnancy failure. |
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| MeSH term(s) | Abortion, Induced ; Animals ; Antigens, Ly/metabolism ; CX3C Chemokine Receptor 1 ; Cells, Cultured ; Female ; Flow Cytometry ; Gene Expression/drug effects ; Interferon-gamma/pharmacology ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/metabolism ; Leukocytes/drug effects ; Leukocytes/metabolism ; Male ; Mice, Inbred BALB C ; Pregnancy ; Pregnancy Outcome ; Receptors, Chemokine/genetics ; Receptors, Chemokine/metabolism ; Receptors, Immunologic/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Spleen/cytology |
| Chemical Substances | Antigens, Ly ; CX3C Chemokine Receptor 1 ; Cx3cr1 protein, mouse ; Ly49P receptor ; Receptors, Chemokine ; Receptors, Immunologic ; Interferon-gamma (82115-62-6) |
| Language | English |
| Publishing date | 2015-12-11 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/srep18159 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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