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  1. TI=Multiple roles of the PI3K PKB Akt pathway in cell cycle progression
  2. TI=Reactivation of Acute Retinal Necrosis following SARS CoV 2 Infection

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  1. Article: Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression.

    Liang, Jiyong / Slingerland, Joyce M

    Cell cycle (Georgetown, Tex.)

    2003  Volume 2, Issue 4, Page(s) 339–345

    Abstract: As its role in tumor progression emerges, the PI3K/PKB (Akt) pathway presents an appealing cancer ... of this pathway. PKB triggers a network that positively regulates G1/S cell cycle progression through inactivation ... of this lipid signaling pathway may lead to cell cycle deregulation in human cancers. The PI3K pathway may also ...

    Abstract As its role in tumor progression emerges, the PI3K/PKB (Akt) pathway presents an appealing cancer therapeutic target. Recent studies have investigated the mechanisms underlying the tumor-promoting effects of this pathway. PKB triggers a network that positively regulates G1/S cell cycle progression through inactivation of GSK3-beta, leading to increased cyclin D1, and inhibition of Forkhead family transcription factors and the tumor suppressor tuberin (TSC2), leading to reduction of p27Kip1. The identification of p21Waf1/Cip1 and p27Kip1 as novel substrates of PKB provided new insights into mechanisms whereby hyperactivation of this lipid signaling pathway may lead to cell cycle deregulation in human cancers. The PI3K pathway may also play a key role in the G2/M transition and its constitutive activation may lead to defects in DNA damage checkpoint control.
    MeSH term(s) Animals ; Blood Proteins/metabolism ; Cell Cycle/physiology ; Cell Cycle Proteins/metabolism ; Cyclin D1/metabolism ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclin-Dependent Kinase Inhibitor p27 ; Cyclins/metabolism ; Enzyme Activation/physiology ; Glycogen Synthase Kinase 3/metabolism ; Glycogen Synthase Kinase 3 beta ; Mice ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Protein Interaction Mapping ; Protein-Serine-Threonine Kinases ; Proteins ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-akt ; Proto-Oncogene Proteins c-myc/metabolism ; Repressor Proteins/metabolism ; Retinoblastoma-Like Protein p130 ; Signal Transduction/physiology ; Tuberous Sclerosis Complex 2 Protein ; Tumor Suppressor Proteins/metabolism
    Chemical Substances Blood Proteins ; Cdkn1a protein, mouse ; Cdkn1b protein, mouse ; Cell Cycle Proteins ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclins ; Proteins ; Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-myc ; Repressor Proteins ; Retinoblastoma-Like Protein p130 ; TSC2 protein, human ; Tsc2 protein, mouse ; Tuberous Sclerosis Complex 2 Protein ; Tumor Suppressor Proteins ; Cyclin D1 (136601-57-5) ; Cyclin-Dependent Kinase Inhibitor p27 (147604-94-2) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Glycogen Synthase Kinase 3 (EC 2.7.11.26)
    Language English
    Publishing date 2003-06-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: eIF4E activity is regulated at multiple levels.

    Raught, B / Gingras, A C

    The international journal of biochemistry & cell biology

    1999  Volume 31, Issue 1, Page(s) 43–57

    Abstract: ... Consistent with this role, eIF4E is required for cell cycle progression, exhibits anti-apoptotic activity ... following phosphorylation of the 4E-BPs by a PI3K-dependent pathway, involving signalling by the anti ... apoptotic kinase Akt/PKB, as well as FRAP/mTOR. ...

    Abstract A key regulatory step in translation is initiation, or the recruitment of the translational machinery to the 5' end of mRNA. The 5' terminus of most mRNAs is demarcated by a m7GpppN cap (where m is a methyl group, and N is any nucleotide). The m7 cap is essential for the translation of most mRNAs, as it directs the translational machinery to the 5' end of the mRNA via its interaction with the cap binding protein, the eukaryotic translation initiation factor 4E (eIF4E). eIF4E is the limiting initiation factor in most cells. Thus, eIF4E activity plays a principal role in determining global translation rates. Consistent with this role, eIF4E is required for cell cycle progression, exhibits anti-apoptotic activity, and, when overexpressed, transforms cells. This review focuses upon the various mechanisms utilized in the regulation of eIF4E activity. (1) eIF4E is regulated transcriptionally; it is one of the few identified transcriptional targets of c-myc. (2) eIF4E is phosphorylated following activation of the MNK1 kinase, a substrate of the ERK and p38 MAPKs. The recent determination of the three-dimensional structure of eIF4E bound to a m7 cap analog has provided insight into the mechanisms involved in the regulation of the eIF4E-cap and eIF4E-mRNA interactions. As suggested by the crystal structure, phosphorylation of eIF4E may enhance its affinity for mRNA. (3) eIF4E is also regulated through binding to a family of translational repressor proteins. Interaction with the 4E-BPs prevents the incorporation of eIF4E into an active translation initiation complex, and thus, inhibits cap-dependent translation. This inhibitory interaction is relieved following phosphorylation of the 4E-BPs by a PI3K-dependent pathway, involving signalling by the anti-apoptotic kinase Akt/PKB, as well as FRAP/mTOR.
    MeSH term(s) Animals ; Apoptosis/physiology ; Cell Division/physiology ; Eukaryotic Initiation Factor-4E ; Gene Expression Regulation ; Humans ; Peptide Initiation Factors/chemistry ; Peptide Initiation Factors/genetics ; Peptide Initiation Factors/metabolism ; Phosphorylation ; Protein Biosynthesis ; Protein Kinases/metabolism ; RNA Caps/genetics ; RNA Caps/metabolism ; Transcription, Genetic
    Chemical Substances Eukaryotic Initiation Factor-4E ; Peptide Initiation Factors ; RNA Caps ; Protein Kinases (EC 2.7.-)
    Language English
    Publishing date 1999-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/s1357-2725(98)00131-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 431: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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