Article ; Online: DNA methylation signature on phosphatidylethanol, not on self-reported alcohol consumption, predicts hazardous alcohol consumption in two distinct populations.
2020 Volume 26, Issue 6, Page(s) 2238–2253
Abstract: The process of diagnosing hazardous alcohol drinking (HAD) is based on self-reported data and is ... that might complement clinical assessment. Because alcohol consumption has been previously linked to DNA methylation ... DNAm), we aimed to select DNAm signatures in blood to predict HAD from two demographically and ...
| Abstract | The process of diagnosing hazardous alcohol drinking (HAD) is based on self-reported data and is thereby vulnerable to bias. There has been an interest in developing epigenetic biomarkers for HAD that might complement clinical assessment. Because alcohol consumption has been previously linked to DNA methylation (DNAm), we aimed to select DNAm signatures in blood to predict HAD from two demographically and clinically distinct populations (N |
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| MeSH term(s) | Alcohol Drinking/genetics ; Biomarkers ; DNA Methylation/genetics ; Glycerophospholipids ; Humans ; Self Report | |||||
| Chemical Substances | Biomarkers ; Glycerophospholipids ; phosphatidylethanol | |||||
| Language | English | |||||
| Publishing date | 2020-02-07 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 1330655-8 | |||||
| ISSN | 1476-5578 ; 1359-4184 | |||||
| ISSN (online) | 1476-5578 | |||||
| ISSN | 1359-4184 | |||||
| DOI | 10.1038/s41380-020-0668-x | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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