Article: High mobility group A: a novel biomarker and therapeutic target in pancreatic adenocarcinoma.
The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
2009 Volume 7, Issue 5, Page(s) 297–306
Abstract: ... candidate biomarker and therapeutic target in pancreatic cancer. This review summarises data implicating ... High mobility group A1 (HMGA1) proteins are architectural transcriptional factors that are over ... HMGA1 as an important mediator of progression in human cancer and in pancreatic cancer. ...
| Abstract | High mobility group A1 (HMGA1) proteins are architectural transcriptional factors that are over-expressed in a wide range of human malignancies. Recently published evidence suggests HMGA1 is a promising candidate biomarker and therapeutic target in pancreatic cancer. This review summarises data implicating HMGA1 as an important mediator of progression in human cancer and in pancreatic cancer. |
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| MeSH term(s) | Adenocarcinoma/genetics ; Adenocarcinoma/therapy ; Biomarkers, Tumor/genetics ; Gene Expression Regulation, Neoplastic ; Genotype ; HMGA1a Protein/genetics ; Humans ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/therapy ; Phenotype | |||||
| Chemical Substances | Biomarkers, Tumor ; HMGA1a Protein (124544-67-8) | |||||
| Language | English | |||||
| Publishing date | 2009-10-22 | |||||
| Publishing country | Scotland | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 2102927-1 | |||||
| ISSN | 1479-666X | |||||
| ISSN | 1479-666X | |||||
| DOI | 10.1016/s1479-666x(09)80008-5 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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