Article: Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer.
2007 Volume 388, Issue 12, Page(s) 1275–1289
Abstract: Salivary agglutinin (SAG), lung glycoprotein-340 (gp-340) and Deleted in Malignant Brain Tumours 1 ... DMBT1) are three names for identical proteins encoded by the dmbt1 gene. DMBT1/SAG/gp-340 belongs ... On the other hand, DMBT1 has been demonstrated to play a role in epithelial and stem cell differentiation ...
| Abstract | Salivary agglutinin (SAG), lung glycoprotein-340 (gp-340) and Deleted in Malignant Brain Tumours 1 (DMBT1) are three names for identical proteins encoded by the dmbt1 gene. DMBT1/SAG/gp-340 belongs to the scavenger receptor cysteine-rich (SRCR) superfamily of proteins, a superfamily of secreted or membrane-bound proteins with SRCR domains that are highly conserved down to sponges, the most ancient metazoa. On the one hand, DMBT1 may represent an innate defence factor acting as a pattern recognition molecule. It interacts with a broad range of pathogens, including cariogenic streptococci and Helicobacter pylori, influenza viruses and HIV, but also with mucosal defence proteins, such as IgA, surfactant proteins and MUC5B. Stimulation of alveolar macrophage migration, suppression of neutrophil oxidative burst and activation of the complement cascade point further to an important role in the regulation of inflammatory responses. On the other hand, DMBT1 has been demonstrated to play a role in epithelial and stem cell differentiation. Inactivation of the gene coding for this protein may lead to disturbed differentiation, possibly resulting in tumour formation. These data strongly point to a role for DMBT1 as a molecule linking innate immune processes with regenerative processes. |
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| MeSH term(s) | Animals ; Brain Neoplasms/genetics ; Cell Differentiation/genetics ; Cell Differentiation/physiology ; Dental Caries/genetics ; Gene Deletion ; Glycosylation ; Humans ; Immunity, Innate/genetics ; Infection/genetics ; Inflammation/genetics ; Neoplasms/genetics ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/immunology ; Receptors, Cell Surface/physiology ; Receptors, Scavenger/genetics ; Regeneration/genetics ; Regeneration/physiology ; Saliva/physiology ; Zona Pellucida/physiology | |||||
| Chemical Substances | DMBT1 protein, human ; Receptors, Cell Surface ; Receptors, Scavenger | |||||
| Language | English | |||||
| Publishing date | 2007-12 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 1334659-3 | |||||
| ISSN | 1437-4315 ; 1431-6730 ; 1432-0355 | |||||
| ISSN (online) | 1437-4315 | |||||
| ISSN | 1431-6730 ; 1432-0355 | |||||
| DOI | 10.1515/BC.2007.158 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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