Article ; Online: Temporal changes of haematological and radiological findings of the COVID-19 infection-a review of literature.
2021 Volume 21, Issue 1, Page(s) 37
Abstract: ... progression of blood and radiology findings of patients with COVID-19.: Methods: Comprehensive systematic ... for peripheral blood investigation and radiological results of COVID-19 patients.: Results: A total of 27 ... The correlation between temporal progression and the reported blood and radiological results may be helpful ...
| Abstract | Background: COVID-19 is a systemic viral infection which mainly targets the human respiratory system with many secondary clinical manifestations especially affecting the hematopoietic system and haemostasis. Few studies have highlighted the prognostic value of blood findings such as lymphopenia, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, LDH, CRP, cardiac troponin, low-density lipoproteins and chest radiographic abnormality. A study of progressions of blood and radiological results may help to identify patients at high risk of severe outcomes. This systematic review aimed to assess the temporal progression of blood and radiology findings of patients with COVID-19. Methods: Comprehensive systematic literature search was conducted on Medline, Embase and Cochrane databases to identify articles published for peripheral blood investigation and radiological results of COVID-19 patients. Results: A total of 27 studies were included in this review. The common laboratory features reported include lymphopenia, elevated levels of C-reactive proteins and lactate dehydrogenase. For radiological signs, ground-glass opacifications, consolidations, and crazy paving patterns were frequently reported. There is a correlation between lymphocyte count, neutrophil count and biomarkers such as C-reactive proteins and lactate dehydrogenase; at a later phase of the disease (more than 7 days since onset of symptoms), lymphopenia worsens while neutrophil count, C-reactive protein levels and lactate dehydrogenase levels increase. Frequencies of ground-glass opacifications and ground-glass opacifications with consolidations decrease at a later phase of the disease while that of consolidation and crazy paving pattern rises as the disease progresses. More extensive lung involvement was also seen more frequently in the later phases. Conclusion: The correlation between temporal progression and the reported blood and radiological results may be helpful to monitor and evaluate disease progression and severity. |
|---|---|
| MeSH term(s) | C-Reactive Protein/metabolism ; COVID-19/blood ; COVID-19/diagnostic imaging ; Disease Progression ; Humans ; L-Lactate Dehydrogenase/blood ; Leukocyte Count ; Lung/diagnostic imaging ; Lymphopenia/blood ; Neutrophils ; SARS-CoV-2 ; Severity of Illness Index |
| Chemical Substances | C-Reactive Protein (9007-41-4) ; L-Lactate Dehydrogenase (EC 1.1.1.27) |
| Language | English |
| Publishing date | 2021-01-22 |
| Publishing country | England |
| Document type | Journal Article ; Systematic Review |
| ZDB-ID | 2059871-3 |
| ISSN | 1471-2466 ; 1471-2466 |
| ISSN (online) | 1471-2466 |
| ISSN | 1471-2466 |
| DOI | 10.1186/s12890-020-01389-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.