Article ; Online: Fulminant granulomatosis with polyangiitis presenting with diffuse alveolar haemorrhage following COVID-19.
BMJ case reports
2021 Volume 14, Issue 6
Abstract: ... The diagnosis of diffuse alveolar haemorrhage secondary to GPA was confirmed with labs, imaging and ... A 40-year-old man developed granulomatosis with polyangiitis (GPA) following a mild case of COVID ... following a COVID-19 infection. ...
| Abstract | A 40-year-old man developed granulomatosis with polyangiitis (GPA) following a mild case of COVID-19. Initially, he experienced mild migrating joint pain for 2 months prior to testing positive for SARS-CoV-2 but dramatically worsened following resolution of his infection. The pain continued to progress until he suddenly develope haemoptysis, prompting him to present to a local hospital. The diagnosis of diffuse alveolar haemorrhage secondary to GPA was confirmed with labs, imaging and histopathology. Precipitous deterioration of GPA with concurrent COVID-19 infection indicates a possible temporal relationship. Since the onset of the pandemic, SARS-CoV-2 has been anecdotally associated with the development of various connective tissue disorders. The overlapping clinical presentations and similar appearance on lung imaging present clinicians with a diagnostic challenge. This underscores the importance of having a high index of suspicion of autoimmune diagnoses in patients who present with new or worsening findings following a COVID-19 infection. |
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| MeSH term(s) | Adult ; COVID-19 ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Hemorrhage/etiology ; Humans ; Lung Diseases/diagnostic imaging ; Lung Diseases/etiology ; Male ; SARS-CoV-2 |
| Language | English |
| Publishing date | 2021-06-21 |
| Publishing country | England |
| Document type | Case Reports ; Journal Article |
| ISSN | 1757-790X |
| ISSN (online) | 1757-790X |
| DOI | 10.1136/bcr-2021-242628 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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