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  1. Article ; Online: Heparin - An old drug with multiple potential targets in Covid-19 therapy.

    Lindahl, Ulf / Li, Jin-Ping

    Journal of thrombosis and haemostasis : JTH

    2020  Volume 18, Issue 9, Page(s) 2422–2424

    MeSH term(s) Anticoagulants/therapeutic use ; Critical Illness ; Glycosaminoglycans/chemistry ; Heparin/therapeutic use ; Heparitin Sulfate/chemistry ; Humans ; Inflammation ; Protein Binding ; Pulmonary Gas Exchange ; Sepsis/complications ; COVID-19 Drug Treatment
    Chemical Substances Anticoagulants ; Glycosaminoglycans ; Heparin (9005-49-6) ; Heparitin Sulfate (9050-30-0)
    Keywords covid19
    Language English
    Publishing date 2020-08-27
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5805: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 295: Show issues

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  3. Article ; Online: Heparin – An old drug with multiple potential targets in Covid‐19 therapy

    Lindahl, Ulf / Li, Jin‐Ping

    Journal of Thrombosis and Haemostasis

    2020  Volume 18, Issue 9, Page(s) 2422–2424

    Keywords Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14898
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5805: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 295: Show issues

    Order via subito

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  4. Article ; Online: The old but new: Can unfractioned heparin and low molecular weight heparins inhibit proteolytic activation and cellular internalization of SARS-CoV2 by inhibition of host cell proteases?

    Belen-Apak, F B / Sarialioglu, F

    Medical hypotheses

    2020  Volume 142, Page(s) 109743

    Abstract: ... no specific antiviral drug or vaccine for COVID-19. The pathogenic infectivity of the virus requires ... Currently, our world is facing the 2019 Novel Coronavirus (COVID-19) outbreak and tremendous ... for their anti inflammatory action) can be potential inhibitors of multiple endoproteases involved in virus infectivity ...

    Abstract Currently, our world is facing the 2019 Novel Coronavirus (COVID-19) outbreak and tremendous efforts are made for developing drugs to treat and vaccines to prevent the disease. At present, there is no specific antiviral drug or vaccine for COVID-19. The pathogenic infectivity of the virus requires the S1 subunit of the spike (S) protein to bind the host cell receptor, angiontensin converting enzyme (ACE2). While the binding to host cell receptor is the first step of infection, the entrance of the virus into the cell needs the cleavage of S1-S2 subunits to expose S2 for fusion to cell membrane via host proteases including cathepsins, cell surface transmembrane protease/serine (TMPRSS) proteases, furin, trypsin and factor Xa. Previous in vitro studies have shown that factor Xa inhibition can decrease viral infectivity. We suppose that host cell proteases including furin (as expressed highly in lungs), factor Xa and cathepsin are possible targets to decrease viral burden, therefore unfractioned heparin and low molecular weight heparin-LMWH (specifically dalteparin and tinzaparin for their anti inflammatory action) can be potential inhibitors of multiple endoproteases involved in virus infectivity. Our hypothesis needs to be tested in in vitro and clinical studies, however as we are in an urgent situation as the burden of SARS-CoV2 is increasing all around the world, we recommend the usage of unfractioned heparin or LMWH in intensive care unit (ICU) and non-ICU hospitalized patients with the risk-benefit judgement of the clinician. Whether our hypothesis is clinically applicable and successful in decreasing viral infection will be evaluated for further studies.
    MeSH term(s) Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/drug therapy ; Drug Administration Schedule ; Factor Xa/metabolism ; Heparin/pharmacology ; Heparin, Low-Molecular-Weight/pharmacology ; Humans ; Models, Theoretical ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/drug therapy ; Protease Inhibitors/pharmacology ; Protein Binding ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus/chemistry
    Chemical Substances Heparin, Low-Molecular-Weight ; Protease Inhibitors ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Heparin (9005-49-6) ; Factor Xa (EC 3.4.21.6)
    Keywords covid19
    Language English
    Publishing date 2020-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1132: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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