Article ; Online: Conservation of telomere protein complexes: shuffling through evolution.
Critical reviews in biochemistry and molecular biology
2009 Volume 44, Issue 6, Page(s) 434–446
Abstract: ... Despite the overall conservation of telomere protein complexes, there is still considerable ... range of telomere protein complexes present in individual species. It is now apparent that versions ... The rapid evolution of telomere proteins has hindered identification of orthologs from diverse ...
| Abstract | The rapid evolution of telomere proteins has hindered identification of orthologs from diverse species and created the impression that certain groups of eukaryotes have largely non-overlapping sets of telomere proteins. However, the recent identification of additional telomere proteins from various model organisms has dispelled this notion by expanding our understanding of the composition, architecture and range of telomere protein complexes present in individual species. It is now apparent that versions of the budding yeast CST complex and mammalian shelterin are present in multiple phyla. While the precise subunit composition and architecture of these complexes vary between species, the general function is often conserved. Despite the overall conservation of telomere protein complexes, there is still considerable species-specific variation, with some organisms having lost a particular subunit or even an entire complex. In some cases, complex components appear to have migrated between the telomere and the telomerase RNP. Finally, gene duplication has created telomere protein paralogs with novel functions. While one paralog may be part of a conserved telomere protein complex and have the expected function, the other paralog may serve in a completely different aspect of telomere biology. |
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| MeSH term(s) | Animals ; Evolution, Molecular ; Genes, Duplicate ; Humans ; Protein Binding ; Telomere/genetics ; Telomere/metabolism ; Telomere-Binding Proteins/chemistry ; Telomere-Binding Proteins/genetics ; Telomere-Binding Proteins/metabolism | |||||
| Chemical Substances | Telomere-Binding Proteins | |||||
| Language | English | |||||
| Publishing date | 2009-10-14 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Review | |||||
| ZDB-ID | 1000977-2 | |||||
| ISSN | 1549-7798 ; 1381-3455 ; 1040-9238 | |||||
| ISSN (online) | 1549-7798 | |||||
| ISSN | 1381-3455 ; 1040-9238 | |||||
| DOI | 10.3109/10409230903307329 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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