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  1. Article: Studies in Diagnostic Teaching: Parker.

    Lipshutz, Samuel / McNally, Lorraine L

    The Psychological clinic

    2017  Volume 17, Issue 8-9, Page(s) 269–273

    Language English
    Publishing date 2017-09-14
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Telephone transfer of nuclear cardiology studies.

    Royal, H D / Parker, J A / Mandell, C H / Uren, R F / Chambers, H M / Jansons, D / Hyman, R M / Kolodny, G M

    Radiology

    1983  Volume 147, Issue 2, Page(s) 590–591

    Abstract: ... from a community hospital to a computer at a teaching hospital for analysis. Interpretations of the studies are dictated ... Data of nuclear cardiology studies are acquired on a computer and transmitted by telephone ... hospital may hear the interpretations by calling into RTAS on the same day as the studies were performed. ...

    Abstract Data of nuclear cardiology studies are acquired on a computer and transmitted by telephone from a community hospital to a computer at a teaching hospital for analysis. Interpretations of the studies are dictated into a RTAS radiology reporting system. The referring physician and transcriptionists from the sending hospital may hear the interpretations by calling into RTAS on the same day as the studies were performed.
    MeSH term(s) Diagnosis, Computer-Assisted/instrumentation ; Diagnosis, Computer-Assisted/methods ; Heart Diseases/diagnostic imaging ; Humans ; Radionuclide Imaging ; Software ; Telephone/instrumentation ; Telephone/methods
    Language English
    Publishing date 1983-05
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiology.147.2.6340161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Renal tubular acidosis in two horses: diagnostic studies.

    Ziemer, E L / Parker, H R / Carlson, G P / Smith, B P / Ishizaki, G

    Journal of the American Veterinary Medical Association

    1987  Volume 190, Issue 3, Page(s) 289–293

    Abstract: ... Teaching Hospital. A series of diagnostic tests was performed in an attempt to characterize the type and cause ... In an attempt to determine the cause of RTA, renal ultrasonography, renal biopsy, and a mating study were ...

    Abstract An 11-year-old Quarter Horse mare and a 2-year-old Quarter Horse colt with clinical diagnoses of renal tubular acidosis (RTA) were donated to the University of California Veterinary Medical Teaching Hospital. A series of diagnostic tests was performed in an attempt to characterize the type and cause of RTA in these horses. Endogenous creatinine clearance and sodium sulfanilate clearance were within reference ranges; thus, no abnormality of glomerular function was detected. To assess renal tubular function in response to acid loading, each horse was given 0.1 g of NH4Cl/kg of body weight via nasogastric tube in 6 L of water. Urine acidification in response to the oral acid load was less than that observed in control horses. The urinary clearance ratio for sodium also was found to be greater for the principals than for the controls. These findings supported a diagnosis of RTA that closely resembled type 1 or distal RTA. In an attempt to determine the cause of RTA, renal ultrasonography, renal biopsy, and a mating study were performed. No abnormalities were identified, and the cause of RTA in these cases remained unknown.
    MeSH term(s) Acidosis, Renal Tubular/diagnosis ; Acidosis, Renal Tubular/veterinary ; Ammonium Chloride/metabolism ; Animals ; Drinking ; Electrolytes/urine ; Female ; Glomerular Filtration Rate ; Horse Diseases/diagnosis ; Horses ; Hydrogen-Ion Concentration ; Male ; Urine ; Water/metabolism
    Chemical Substances Electrolytes ; Ammonium Chloride (01Q9PC255D) ; Water (059QF0KO0R)
    Language English
    Publishing date 1987-02-01
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390811-2
    ISSN 1943-569X ; 0003-1488
    ISSN (online) 1943-569X
    ISSN 0003-1488
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  4. Article ; Online: Influenza presentations and use of neuraminidase inhibitors by Australian general practice registrars: a cross-sectional analysis from the ReCEnT study.

    Moller, Chris / van Driel, Mieke / Davey, Andrew / Tapley, Amanda / Holliday, Elizabeth G / Fielding, Alison / Davis, Joshua / Ball, Jean / Ralston, Anna / Turner, Alexandria / Mulquiney, Katie / Spike, Neil / Fitzgerald, Kristen / Magin, Parker

    Family medicine and community health

    2023  Volume 11, Issue 2

    Abstract: ... of prescribing NAIs for IILI.: Setting: Teaching practices within the Australian general practitioner ... Objective: This study aims to establish prevalence and associations of (1) influenza and influenza ... three times (from 60 consecutive consultations each time) at 6 monthly intervals. Data include diagnoses ...

    Abstract Objective: This study aims to establish prevalence and associations of (1) influenza and influenza-like illness (IILI) presentations to Australian general practice (GP) registrars (trainees) and (2) the use of neuraminidase inhibitors (NAIs) by GP registrars for new presentations of IILI, for the 10 years leading up to the COVID-19 pandemic in Australia (2010-2019).
    Design: This was a cross-sectional analysis of the Registrar Clinical Encounters in Training ongoing inception cohort study of the in-consultation experience and clinical behaviours of GP registrars. Data are collected by individual registrars three times (from 60 consecutive consultations each time) at 6 monthly intervals. Data include diagnoses/problems managed and medicines prescribed, along with multiple other variables. Univariate and multivariable logistic regression was used to establish associations of registrars seeing patients with IILI and of prescribing NAIs for IILI.
    Setting: Teaching practices within the Australian general practitioner specialist vocational training programme. Practices were located in five of the six Australian states (plus one territory).
    Participants: GP registrars in each of their three compulsory 6-month GP training terms.
    Results: From 2010 to 2019, 0.2% of diagnoses/problems seen by registrars were IILI. 15.4% of new IILI presentations were prescribed an NAI. IILI diagnoses were less likely in younger (0-14) and older (65+) age groups, and more likely in an area of higher socioeconomic advantage. There was considerable variation in NAI prescribing between regions. There was no significant association of prescribing NAIs with age or Aboriginal and/or Torres Strait Islander patients.
    Conclusions: IILI presentations were more likely among working-age adults and not among those groups at higher risk. Similarly, high-risk patient groups who would benefit most were not more likely to receive NAIs. The epidemiology and management of IILI has been distorted by the COVID-19 pandemic, but the burden of influenza in vulnerable populations must not be overlooked. Appropriately targeted antiviral therapy with NAIs influences outcomes for vulnerable patients. General practitioners manage the majority of IILI in Australia, and understanding GP IILI presentation and NAI prescribing patterns is a key first step to enabling sound and rational prescribing decisions for better patient outcomes.
    MeSH term(s) Adult ; Humans ; Antiviral Agents/therapeutic use ; Australia ; Central Nervous System Depressants ; Cohort Studies ; COVID-19 ; Cross-Sectional Studies ; General Practice ; General Practitioners ; Influenza, Human/drug therapy ; Influenza, Human/epidemiology ; Neuraminidase ; Pandemics
    Chemical Substances Antiviral Agents ; Central Nervous System Depressants ; Neuraminidase (EC 3.2.1.18)
    Language English
    Publishing date 2023-06-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2986753-8
    ISSN 2009-8774 ; 2305-6983
    ISSN (online) 2009-8774
    ISSN 2305-6983
    DOI 10.1136/fmch-2022-002107
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  5. Article ; Online: MRI-based Neuropathy Score Reporting And Data System (NS-RADS): multi-institutional wider-experience usability study of peripheral neuropathy conditions among 32 radiology readers.

    Chhabra, Avneesh / Duarte Silva, Flavio / Mogharrabi, Bayan / Guirguis, Mina / Ashikyan, Oganes / Rasper, Michael / Park, Eunhae / Walter, Sven S / Umpierrez, Monica / Pezeshk, Parham / Thurlow, Peter C / Jagadale, Akshaya / Bajaj, Gitanjali / Komarraju, Aparna / Wu, Jim S / Aguilera, Antonio / Cardoso, Fabiano Nassar / Souza, Felipe / Chaganti, SubbaRao /
    Antil, Neha / Manzano, Wilfred / Stebner, Alexander / Evers, Jochen / Petterson, Matthew / Geisbush, Thomas / Downing, Chad / Christensen, Diana / Horneber, Elizabeth / Kim, Jun Man / Purushothaman, Rangarajan / Mohanan, Shilpa / Raichandani, Surbhi / Vilanilam, George / Cabrera, Clementina / Manov, John / Maloney, Sean / Deshmukh, Swati D / Lutz, Amelie M / Fritz, Jan / Andreisek, Gustav / Chalian, Majid / Wong, Philip K / Pandey, Tarun / Subhawong, Ty / Xi, Yin

    European radiology

    2024  

    Abstract: ... experience levels after limited teaching of the scoring system.: Methods: This is a multi-institutional ... Objective: To determine the inter-reader reliability and diagnostic performance of classification ... agreements were evaluated by Conger's kappa and diagnostic accuracy was calculated for each reader as percent ...

    Abstract Objective: To determine the inter-reader reliability and diagnostic performance of classification and severity scales of Neuropathy Score Reporting And Data System (NS-RADS) among readers of differing experience levels after limited teaching of the scoring system.
    Methods: This is a multi-institutional, cross-sectional, retrospective study of MRI cases of proven peripheral neuropathy (PN) conditions. Thirty-two radiology readers with varying experience levels were recruited from different institutions. Each reader attended and received a structured presentation that described the NS-RADS classification system containing examples and reviewed published articles on this subject. The readers were then asked to perform NS-RADS scoring with recording of category, subcategory, and most likely diagnosis. Inter-reader agreements were evaluated by Conger's kappa and diagnostic accuracy was calculated for each reader as percent correct diagnosis. A linear mixed model was used to estimate and compare accuracy between trainees and attendings.
    Results: Across all readers, agreement was good for NS-RADS category and moderate for subcategory. Inter-reader agreement of trainees was comparable to attendings (0.65 vs 0.65). Reader accuracy for attendings was 75% (95% CI 73%, 77%), slightly higher than for trainees (71% (69%, 72%), p = 0.0006) for nerves and comparable for muscles (attendings, 87.5% (95% CI 86.1-88.8%) and trainees, 86.6% (95% CI 85.2-87.9%), p = 0.4). NS-RADS accuracy was also higher than average accuracy for the most plausible diagnosis for attending radiologists at 67% (95% CI 63%, 71%) and for trainees at 65% (95% CI 60%, 69%) (p = 0.036).
    Conclusion: Non-expert radiologists interpreted PN conditions with good accuracy and moderate-to-good inter-reader reliability using the NS-RADS scoring system.
    Clinical relevance statement: The Neuropathy Score Reporting And Data System (NS-RADS) is an accurate and reliable MRI-based image scoring system for practical use for the diagnosis and grading of severity of peripheral neuromuscular disorders by both experienced and general radiologists.
    Key points: • The Neuropathy Score Reporting And Data System (NS-RADS) can be used effectively by non-expert radiologists to categorize peripheral neuropathy. • Across 32 different experience-level readers, the agreement was good for NS-RADS category and moderate for NS-RADS subcategory. • NS-RADS accuracy was higher than the average accuracy for the most plausible diagnosis for both attending radiologists and trainees (at 75%, 71% and 65%, 65%, respectively).
    Language English
    Publishing date 2024-01-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-10517-2
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  6. Article ; Online: Prediction of Pleural Adhesions by Lung Ultrasonography: An Observational Study.

    Jeong, Heejoon / Choi, Ji Won / Ahn, Hyun Joo / Choi, Jisun / Park, Joo Hyun

    Journal of cardiothoracic and vascular anesthesia

    2020  Volume 35, Issue 2, Page(s) 565–570

    Abstract: ... investigated.: Design: Blinded, prospective, observational study.: Setting: Tertiary teaching ... study, the feasibility of lung ultrasonography for the prediction of pleural adhesions and postoperative pain in VATS was ...

    Abstract Objective: Pleural adhesion makes video-assisted thoracoscopic surgery (VATS) an arduous procedure and can increase postoperative pain from accompanying adhesiolysis. For the present study, the feasibility of lung ultrasonography for the prediction of pleural adhesions and postoperative pain in VATS was investigated.
    Design: Blinded, prospective, observational study.
    Setting: Tertiary teaching hospital, Seoul, South Korea.
    Participants: Sixty patients (American Society of Anesthesiologists physical status I to III) scheduled to undergo VATS were assessed for eligibility. After exclusions, 53 patients were enrolled and followed-up.
    Interventions: None.
    Measurements and main results: Patients were evaluated with lung ultrasonography during deep spontaneous respiration before induction of anesthesia, and surgeons confirmed the presence of pleural adhesions during the surgery. Pain was evaluated using a numeric rating scale and by the amount of opioid consumption until 24 hours postoperatively. Lung ultrasonography showed acceptable predictability of pleural adhesions, with the area under the receiver operating characteristic curve (0.75, 95% confidence interval [CI] 0.67-0.83) and high specificity (0.97, 95% CI 0.91-0.99) but low sensitivity (0.53, 95% CI 0.38-0.68). The pain score was not different between sonographic adhesion (+) and (-) groups; however, the sonographic adhesion (+) group consumed more opioids until 24 hours postoperatively (fentanyl 675 [558-805] μg v 420 [356-476] μg; p < 0.001).
    Conclusions: Lung ultrasonography may help with planning postoperative pain management in VATS; however, it was a better tool for ruling out rather than detecting pleural adhesions.
    MeSH term(s) Humans ; Lung/diagnostic imaging ; Lung/surgery ; Pleural Diseases/diagnostic imaging ; Prospective Studies ; Republic of Korea ; Thoracic Surgery, Video-Assisted ; Ultrasonography
    Language English
    Publishing date 2020-06-13
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2020.06.030
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  7. Article ; Online: Operating bedside cardiac ultrasound program in emergency medicine residency: A retrospective observation study from the perspective of performance improvement.

    Kim, Ki Hong / Jung, Jae Yun / Park, Joong Wan / Lee, Min Sung / Lee, Yong Hee

    PloS one

    2021  Volume 16, Issue 4, Page(s) e0248710

    Abstract: ... PoCUS) database in one tertiary academic-teaching hospital emergency department has been conducted ... Background: Point-of-care ultrasound is one of useful diagnostic tools in emergency medicine ... practice and considerably depends on physician's performance. This study was performed to evaluate ...

    Abstract Background: Point-of-care ultrasound is one of useful diagnostic tools in emergency medicine practice and considerably depends on physician's performance. This study was performed to evaluate performance improvements and favorable attitudes through structured cardiac ultrasound program for emergency medicine residents.
    Methods: Retrospective observational study using the point-of-care ultrasound (PoCUS) database in one tertiary academic-teaching hospital emergency department has been conducted. Cardiac ultrasound education and rotation program has been implemented in emergency medicine residency program. Structured evaluation sheet for cardiac ultrasound and questionnaire toward PoCUS have been developed. An early-phase and a late-phase case were selected randomly for each participant. Two emergency medicine specialists with expertise in PoCUS evaluated saved images independently. We used a paired t-test to compare the performance score of each phase and the results of the questionnaire. Multivariable linear regression analysis was conducted to evaluate the association between the characteristics of participants and performance improvements.
    Results: During the study period, a total of 1,652 bedside cardiac ultrasounds were administered. Forty-six examinations conducted by 23 emergency medicine residents were randomly selected for analysis. The performance score increased from 39.5 to 56.1 according to expert A and 45.3 to 62.9 according to expert B (p-value <0.01 for both). The average questionnaire score, which was analyzed for 17 participants, showed improvement from 18.9 to 20.7 (p-value <0.01). In multivariable linear regression analysis, younger age, higher early-phase score and higher confidence had a negative association with a greater improvement of performance, while the number of examinations had a positive association.
    Conclusions: Bedside cardiac ultrasound performance and attitudes toward PoCUS have been improved through structured residency program.
    MeSH term(s) Adult ; Echocardiography/methods ; Emergency Medicine/education ; Hospitals, Teaching ; Humans ; Internship and Residency ; Point-of-Care Systems ; Retrospective Studies
    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Journal Article ; Observational Study
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0248710
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  8. Article ; Online: Randomized, noninferiority study between video versus hand ultrasound with wet foam dressing materials to simulate B-lines in lung ultrasound: A CONSORT-compliant article.

    Park, Eun Jung / Yoon, Young Tak / Hong, Chong Kun / Ha, Young Rock / Ahn, Jung Hwan

    Medicine

    2017  Volume 96, Issue 30, Page(s) e7642

    Abstract: ... B-lines. They were effective for teaching and simulations.: Trial registration: The study was ... Background: This study evaluated the efficacy of a teaching method using simulated B-lines of hand ... ultrasound with a wet foam dressing material.: Methods: This prospective, randomized, noninferiority study ...

    Abstract Background: This study evaluated the efficacy of a teaching method using simulated B-lines of hand ultrasound with a wet foam dressing material.
    Methods: This prospective, randomized, noninferiority study was conducted on emergency medical technician students without any relevant training in ultrasound. Following a lecture including simulated (SG) or real video clips (RG) of B-lines, a posttest was conducted and a retention test was performed after 2 months. The test consisted of questions about B-lines in 40 randomly mixed video clips (20 simulated and 20 real videos) with 4 answer scores (R-1 [the correct answer score for the real video clips] vs S-1 [the correct answer score for the simulated video clips] in the posttest, R-2 [the correct answer score for the real video clips] vs S-2 [the correct answer score for the simulated video clips] in the retention test).
    Results: A total of 77 and 73 volunteers participated in the posttest (RG, 38; SG, 39) and retention test (RG, 36; SG, 37), respectively. There was no significant (P > .05) difference in scores of R-1, S-1, R-2, or S-2 between RG and SG. The mean score differences between RG and SG were -0.6 (95% confidence interval [CI]: -1.49 to 0.11) in R-1, -0.1 (95% CI: -1.04 to 0.86) in S-1, 0 (95% CI: -1.57 to 1.50) in R-2, and -0.2 (95% CI: -1.52 to 0.25) in S-2. The mean differences and 95% CIs for all parameters fell within the noninferiority margin of 2 points (10%).
    Conclusion: Simulated B-lines of hand ultrasound with a wet foam dressing material were not inferior to real B-lines. They were effective for teaching and simulations.
    Trial registration: The study was registered with the Clinical Trial Registry of Korea: https://cris.nih.go.kr/cris/index.jsp (KCT0002144).
    MeSH term(s) Bandages ; Clinical Competence ; Emergency Medical Technicians/education ; Female ; Humans ; Learning ; Lung/diagnostic imaging ; Male ; Models, Anatomic ; Polyurethanes ; Republic of Korea ; Simulation Training ; Ultrasonography ; Video Recording ; Water ; Young Adult
    Chemical Substances Polyurethanes ; Water (059QF0KO0R)
    Language English
    Publishing date 2017-08-02
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000007642
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  9. Article: Safety and Utility of Spinal Magnetic Resonance Imaging in Patients with High-Frequency Spinal Cord Stimulators: A Prospective Single-Centre Study

    Manfield, James / Bartlett, Richard / Park, Nicholas

    Stereotactic and Functional Neurosurgery

    2019  Volume 97, Issue 4, Page(s) 272–277

    Abstract: ... illustrate this with 2 representative patient cases. Results: The imaging studies were well tolerated ... diagnostic quality imaging. Objectives: To describe our experience with 9 such scans, demonstrating that safe ... computed tomography myelography. To our knowledge, this is the first reported study of MRI in HF-SCS ...

    Institution Department of Neurosurgery, Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom
    Department of Radiology, Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom
    Abstract Background: Implanted high-frequency spinal cord stimulators at 10 kHz (HF-SCS) have recently acquired conditional approval for magnetic resonance imaging (MRI), including retrospective application to previously implanted devices. Under certain conditions, there are greater specific absorption rate (SAR) scanning restrictions compared to some conventional alternatives. This poses technical challenges to obtain diagnostic quality imaging. Objectives: To describe our experience with 9 such scans, demonstrating that safe and diagnostically useful images can be obtained despite these restrictions. Methods: We report a prospective single-centre series of 9 scans within a tertiary neuroscience centre, all obtained within the required SAR limit of ≤0.4 W/kg, and describe the scanning protocol we have developed. We further illustrate this with 2 representative patient cases. Results: The imaging studies were well tolerated without complication. In all cases, the imaging quality was sufficient for the reporting neuroradiologist to answer the clinical question posed. Conclusion: Despite technical challenges, MRI is feasible, safe and diagnostically useful in HF-SCS-implanted patients. We would invite other centres that implant these devices to consider the development of their own scanning protocols to avoid the morbidity and inconvenience of explantation or computed tomography myelography. To our knowledge, this is the first reported study of MRI in HF-SCS-implanted patients achieving the requisite SAR limit of ≤0.4 W/kg.
    Keywords Spinal magnetic resonance imaging ; Spinal cord stimulation ; High-fequency spinal cord stimulator implantation
    Language English
    Publishing date 2019-10-25
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Case Report ; This article is licensed under the Creative Commons Attribution 4.0 International License (CC BY).
    ZDB-ID 645069-6
    ISSN 1423-0372 ; 1011-6125
    ISSN (online) 1423-0372
    ISSN 1011-6125
    DOI 10.1159/000503730
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  10. Article ; Online: Prothrombin Time and Activated Partial Thromboplastin Time Testing: A Comparative Effectiveness Study in a Million-Patient Sample.

    Capoor, Manu N / Stonemetz, Jerry L / Baird, John C / Ahmed, Fahad S / Awan, Ahsan / Birkenmaier, Christof / Inchiosa, Mario A / Magid, Steven K / McGoldrick, Kathryn / Molmenti, Ernesto / Naqvi, Sajjad / Parker, Stephen D / Pothula, S M / Shander, Aryeh / Steen, R Grant / Urban, Michael K / Wall, Judith / Fischetti, Vincent A

    PloS one

    2015  Volume 10, Issue 8, Page(s) e0133317

    Abstract: ... prospectively-collected patient data from 19 major teaching hospitals and 8 hospital-affiliated surgical centers ... undiagnosed potential bleeding risk). Both PT and aPTT, designed as diagnostic tests, are apparently used ... for testing.: Conclusions: This study sought to bring the availability of big data together with applied ...

    Abstract Background: A substantial fraction of all American healthcare expenditures are potentially wasted, and practices that are not evidence-based could contribute to such waste. We sought to characterize whether Prothrombin Time (PT) and activated Partial Thromboplastin Time (aPTT) tests of preoperative patients are used in a way unsupported by evidence and potentially wasteful.
    Methods and findings: We evaluated prospectively-collected patient data from 19 major teaching hospitals and 8 hospital-affiliated surgical centers in 7 states (Delaware, Florida, Maryland, Massachusetts, New Jersey, New York, Pennsylvania) and the District of Columbia. A total of 1,053,472 consecutive patients represented every patient admitted for elective surgery from 2009 to 2012 at all 27 settings. A subset of 682,049 patients (64.7%) had one or both tests done and history and physical (H&P) records available for analysis. Unnecessary tests for bleeding risk were defined as: PT tests done on patients with no history of abnormal bleeding, warfarin therapy, vitamin K-dependent clotting factor deficiency, or liver disease; or aPTT tests done on patients with no history of heparin treatment, hemophilia, lupus anticoagulant antibodies, or von Willebrand disease. We assessed the proportion of patients who received PT or aPTT tests who lacked evidence-based reasons for testing.
    Conclusions: This study sought to bring the availability of big data together with applied comparative effectiveness research. Among preoperative patients, 26.2% received PT tests, and 94.3% of tests were unnecessary, given the absence of findings on H&P. Similarly, 23.3% of preoperative patients received aPTT tests, of which 99.9% were unnecessary. Among patients with no H&P findings suggestive of bleeding risk, 6.6% of PT tests and 7.1% of aPTT tests were either a false positive or a true positive (i.e. indicative of a previously-undiagnosed potential bleeding risk). Both PT and aPTT, designed as diagnostic tests, are apparently used as screening tests. Use of unnecessary screening tests raises concerns for the costs of such testing and the consequences of false positive results.
    MeSH term(s) Adult ; Aged ; Evidence-Based Practice/methods ; Evidence-Based Practice/standards ; Evidence-Based Practice/statistics & numerical data ; Female ; Hospitals, Teaching ; Humans ; Male ; Middle Aged ; Partial Thromboplastin Time ; Preoperative Care/methods ; Preoperative Care/standards ; Preoperative Care/statistics & numerical data ; Prothrombin Time ; United States ; Unnecessary Procedures ; Young Adult
    Language English
    Publishing date 2015-08-11
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0133317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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