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  1. Article ; Online: Acquired long QT syndrome in chronic kidney disease patients.

    Liu, Peng / Wang, Lu / Han, Dan / Sun, Chaofeng / Xue, Xiaolin / Li, Guoliang

    Renal failure

    2019  Volume 42, Issue 1, Page(s) 54–65

    Abstract: ... in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated ... in the general population. The prevalence of acquired long QT syndrome (aLQTS) is high, and various acquired conditions ... contribute to the prolonged QT interval in patients with CKD. More notably, the prolonged QT interval in CKD ...

    Abstract Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in chronic kidney disease (CKD) patients. QT interval prolongation is a congenital or acquired condition that is associated with an increased risk of torsade de pointes (TdP), sudden cardiac death (SCD), and all-cause mortality in the general population. The prevalence of acquired long QT syndrome (aLQTS) is high, and various acquired conditions contribute to the prolonged QT interval in patients with CKD. More notably, the prolonged QT interval in CKD is an independent risk factor for SCD and all-cause mortality. In this review, we focus on the epidemiological characteristics, risk factors, underlying mechanisms and treatments of aLQTS in CKD, promoting the management of aLQTS in CKD patients.
    MeSH term(s) Anti-Arrhythmia Agents/therapeutic use ; Cardiac Pacing, Artificial/methods ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Electrocardiography ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Heart Rate/drug effects ; Humans ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation/adverse effects ; Long QT Syndrome/diagnosis ; Long QT Syndrome/epidemiology ; Long QT Syndrome/etiology ; Long QT Syndrome/therapy ; Prevalence ; Renal Dialysis/adverse effects ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/mortality ; Renal Insufficiency, Chronic/therapy ; Review Literature as Topic ; Risk Factors
    Chemical Substances Anti-Arrhythmia Agents ; Immunosuppressive Agents
    Language English
    Publishing date 2019-12-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2019.1707098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1331: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Prevalence and risk factors of acquired long QT syndrome in hospitalized patients with chronic kidney disease.

    Liu, Peng / Han, Dan / Sun, Xuanzi / Tan, Hui / Wang, Zhigang / Liu, Chao / Zhang, Yali / Li, Bailin / Sun, Chaofeng / Shi, Rui / Li, Guoliang

    Journal of investigative medicine : the official publication of the American Federation for Clinical Research

    2018  Volume 67, Issue 2, Page(s) 289–294

    Abstract: ... The objective of this study was to evaluate the prevalence of acquired long QT syndrome (aLQTS) in hospitalized ... Patients with chronic kidney disease (CKD) have a high risk of fatal arrhythmias. The extended ... with the decline of kidney function in hospitalized patients with CKD, which is related to older age, impaired ...

    Abstract Patients with chronic kidney disease (CKD) have a high risk of fatal arrhythmias. The extended severe corrected QT (QTc) interval is a hallmark of ventricular arrhythmias and sudden cardiac death. The objective of this study was to evaluate the prevalence of acquired long QT syndrome (aLQTS) in hospitalized patients with CKD and search for potential risk factors to improve clinical risk stratification in patients with CKD. Information about patients with CKD was retrospectively collected in our hospital between January 2013 and June 2017. The prevalence of aLQTS in different stages of CKD was evaluated. The common risk factors for QTc prolongation in patients with CKD were compiled, and multivariable logistic regression analysis was used to evaluate how each factor was related to aLQTS in CKD. A total of 804 patients with CKD (299 females, 37.2%) participated in our study. The prevalence of aLQTS among all 804 patients was 56.97%, and the prevalence of QTc prolongation (>500 ms) was 10.07%. Among the elderly, impaired kidney function, hemodialysis, low serum potassium and low left ventricular ejection fraction (LVEF) were associated with QTc prolongation in patients with CKD. The prevalence of aLQTS is much higher and increases with the decline of kidney function in hospitalized patients with CKD, which is related to older age, impaired kidney function, hemodialysis, serum potassium and low LVEF.
    MeSH term(s) China/epidemiology ; Female ; Hospitalization ; Humans ; Long QT Syndrome/complications ; Long QT Syndrome/epidemiology ; Male ; Middle Aged ; Prevalence ; Renal Insufficiency, Chronic/complications ; Risk Factors
    Language English
    Publishing date 2018-10-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1217870-6
    ISSN 1708-8267 ; 0009-9279 ; 1081-5589
    ISSN (online) 1708-8267
    ISSN 0009-9279 ; 1081-5589
    DOI 10.1136/jim-2018-000798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 307: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The anti-aging factor Klotho protects against acquired long QT syndrome induced by uremia and promoted by fibroblast growth factor 23.

    Navarro-García, José Alberto / Salguero-Bodes, Rafael / González-Lafuente, Laura / Martín-Nunes, Laura / Rodríguez-Sánchez, Elena / Bada-Bosch, Teresa / Hernández, Eduardo / Mérida-Herrero, Evangelina / Praga, Manuel / Solís, Jorge / Arribas, Fernando / Bueno, Héctor / Kuro-O, Makoto / Fernández-Velasco, María / Ruilope, Luis Miguel / Delgado, Carmen / Ruiz-Hurtado, Gema

    BMC medicine

    2022  Volume 20, Issue 1, Page(s) 14

    Abstract: ... Klotho signaling axis and acquired long QT syndrome in CKD-associated uremia. FGF23 levels and cardiac ... Patients in the top quartile of FGF23 levels had a higher occurrence of very long QT intervals (> 490 ms ... long QT syndrome in uremia by minimizing the predisposition to potentially fatal ventricular ...

    Abstract Background: Chronic kidney disease (CKD) is associated with increased propensity for arrhythmias. In this context, ventricular repolarization alterations have been shown to predispose to fatal arrhythmias and sudden cardiac death. Between mineral bone disturbances in CKD patients, increased fibroblast growth factor (FGF) 23 and decreased Klotho are emerging as important effectors of cardiovascular disease. However, the relationship between imbalanced FGF23-Klotho axis and the development of cardiac arrhythmias in CKD remains unknown.
    Methods: We carried out a translational approach to study the relationship between the FGF23-Klotho signaling axis and acquired long QT syndrome in CKD-associated uremia. FGF23 levels and cardiac repolarization dynamics were analyzed in patients with dialysis-dependent CKD and in uremic mouse models of 5/6 nephrectomy (Nfx) and Klotho deficiency (hypomorphism), which show very high systemic FGF23 levels.
    Results: Patients in the top quartile of FGF23 levels had a higher occurrence of very long QT intervals (> 490 ms) than peers in the lowest quartile. Experimentally, FGF23 induced QT prolongation in healthy mice. Similarly, alterations in cardiac repolarization and QT prolongation were observed in Nfx mice and in Klotho hypomorphic mice. QT prolongation in Nfx mice was explained by a significant decrease in the fast transient outward potassium (K
    Conclusion: The FGF23-Klotho axis emerges as a new therapeutic target to prevent acquired long QT syndrome in uremia by minimizing the predisposition to potentially fatal ventricular arrhythmias and sudden cardiac death in patients with CKD.
    MeSH term(s) Aging ; Animals ; Fibroblast Growth Factor-23 ; Fibroblast Growth Factors/genetics ; Glucuronidase/genetics ; Humans ; Klotho Proteins ; Long QT Syndrome ; Mice ; Renal Insufficiency, Chronic/complications ; Uremia/complications
    Chemical Substances FGF23 protein, human ; Fgf23 protein, mouse ; KLB protein, human ; Fibroblast Growth Factors (62031-54-3) ; Fibroblast Growth Factor-23 (7Q7P4S7RRE) ; Glucuronidase (EC 3.2.1.31) ; Klotho Proteins (EC 3.2.1.31)
    Language English
    Publishing date 2022-01-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2131669-7
    ISSN 1741-7015 ; 1741-7015
    ISSN (online) 1741-7015
    ISSN 1741-7015
    DOI 10.1186/s12916-021-02209-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The anti-aging factor Klotho protects against acquired long QT syndrome induced by uremia and promoted by fibroblast growth factor 23

    José Alberto Navarro-García / Rafael Salguero-Bodes / Laura González-Lafuente / Laura Martín-Nunes / Elena Rodríguez-Sánchez / Teresa Bada-Bosch / Eduardo Hernández / Evangelina Mérida-Herrero / Manuel Praga / Jorge Solís / Fernando Arribas / Héctor Bueno / Makoto Kuro-O / María Fernández-Velasco / Luis Miguel Ruilope / Carmen Delgado / Gema Ruiz-Hurtado

    BMC Medicine, Vol 20, Iss 1, Pp 1-

    2022  Volume 19

    Abstract: ... Klotho signaling axis and acquired long QT syndrome in CKD-associated uremia. FGF23 levels and cardiac ... acquired long QT syndrome in uremia by minimizing the predisposition to potentially fatal ventricular ... Patients in the top quartile of FGF23 levels had a higher occurrence of very long QT intervals (> 490 ms ...

    Abstract Abstract Background Chronic kidney disease (CKD) is associated with increased propensity for arrhythmias. In this context, ventricular repolarization alterations have been shown to predispose to fatal arrhythmias and sudden cardiac death. Between mineral bone disturbances in CKD patients, increased fibroblast growth factor (FGF) 23 and decreased Klotho are emerging as important effectors of cardiovascular disease. However, the relationship between imbalanced FGF23-Klotho axis and the development of cardiac arrhythmias in CKD remains unknown. Methods We carried out a translational approach to study the relationship between the FGF23–Klotho signaling axis and acquired long QT syndrome in CKD-associated uremia. FGF23 levels and cardiac repolarization dynamics were analyzed in patients with dialysis-dependent CKD and in uremic mouse models of 5/6 nephrectomy (Nfx) and Klotho deficiency (hypomorphism), which show very high systemic FGF23 levels. Results Patients in the top quartile of FGF23 levels had a higher occurrence of very long QT intervals (> 490 ms) than peers in the lowest quartile. Experimentally, FGF23 induced QT prolongation in healthy mice. Similarly, alterations in cardiac repolarization and QT prolongation were observed in Nfx mice and in Klotho hypomorphic mice. QT prolongation in Nfx mice was explained by a significant decrease in the fast transient outward potassium (K+) current (I tof ), caused by the downregulation of K+ channel 4.2 subunit (Kv4.2) expression. Kv4.2 expression was also significantly reduced in ventricular cardiomyocytes exposed to FGF23. Enhancing Klotho availability prevented both long QT prolongation and reduced I tof current. Likewise, administration of recombinant Klotho blocked the downregulation of Kv4.2 expression in Nfx mice and in FGF23-exposed cardiomyocytes. Conclusion The FGF23–Klotho axis emerges as a new therapeutic target to prevent acquired long QT syndrome in uremia by minimizing the predisposition to potentially fatal ventricular arrhythmias and sudden cardiac ...
    Keywords CKD ; Dialysis ; FGF23 ; Klotho ; Long QT ; Potassium channels ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Identification of important risk factors for all-cause mortality of acquired long QT syndrome patients using random survival forests and non-negative matrix factorization.

    Chen, Cheng / Zhou, Jiandong / Yu, Haixu / Zhang, Qingpeng / Gao, Lianjun / Yin, Xiaomeng / Dong, Yingxue / Lin, Yajuan / Li, Daobo / Yang, Yiheng / Wang, Yunsong / Tse, Gary / Xia, Yunlong

    Heart rhythm

    2020  Volume 18, Issue 3, Page(s) 426–433

    Abstract: Background: Acquired long QT syndrome (aLQTS) is often associated with poor clinical outcomes ... QTp interval, chronic kidney disease, QTc interval, hypertension, QT interval, female, JTc interval ... of aLQTS patients by applying both random survival forest (RSF) and non-negative matrix factorization (NMF ...

    Abstract Background: Acquired long QT syndrome (aLQTS) is often associated with poor clinical outcomes.
    Objective: The purpose of this study was to examine the important predictors of all-cause mortality of aLQTS patients by applying both random survival forest (RSF) and non-negative matrix factorization (NMF) analyses.
    Methods: Clinical characteristics and manually measured electrocardiographic (ECG) parameters were initially entered into the RSF model. Subsequently, latent variables identified using NMF were entered into the RSF as additional variables. The primary outcome was all-cause mortality.
    Results: A total of 327 aLQTS patients were included. The RSF model identified 16 predictive factors with positive variable importance values: cancer, potassium, RR interval, calcium, age, JT interval, diabetes mellitus, QRS duration, QTp interval, chronic kidney disease, QTc interval, hypertension, QT interval, female, JTc interval, and cerebral hemorrhage. Increasing the number of latent features between ECG indices, which incorporated from n = 0 to n = 4 by NMF, maximally improved the prediction ability of the RSF-NMF model (C-statistic 0.77 vs 0.89).
    Conclusion: Cancer and serum potassium and calcium levels can predict all-cause mortality of aLQTS patients, as can ECG indicators including JTc and QRS. The present RSF-NMF model significantly improved mortality prediction.
    MeSH term(s) Algorithms ; Cause of Death/trends ; China/epidemiology ; Electrocardiography ; Female ; Follow-Up Studies ; Heart Rate/physiology ; Humans ; Long QT Syndrome/mortality ; Long QT Syndrome/physiopathology ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Survival Rate/trends
    Language English
    Publishing date 2020-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2020.10.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6278: Show issues Location:
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