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  1. Article ; Online: COVID-19: Complement, Coagulation, and Collateral Damage.

    Lo, Martin W / Kemper, Claudia / Woodruff, Trent M

    Journal of immunology (Baltimore, Md. : 1950)

    2020  Volume 205, Issue 6, Page(s) 1488–1495

    Abstract: ... a summary of COVID-19 and review complement's role in COVID-19 acute respiratory distress syndrome and ... that the complement system plays a key role in this inflammatory reaction. Indeed, patients with severe COVID-19 show ... with complement inhibitors all recovered with no adverse reactions. These and other studies hint at complement's ...

    Abstract Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused by the severe acute respiratory syndrome coronavirus 2. Although most people are immunocompetent to the virus, a small group fail to mount an effective antiviral response and develop chronic infections that trigger hyperinflammation. This results in major complications, including acute respiratory distress syndrome, disseminated intravascular coagulation, and multiorgan failure, which all carry poor prognoses. Emerging evidence suggests that the complement system plays a key role in this inflammatory reaction. Indeed, patients with severe COVID-19 show prominent complement activation in their lung, skin, and sera, and those individuals who were treated with complement inhibitors all recovered with no adverse reactions. These and other studies hint at complement's therapeutic potential in these sequalae, and thus, to support drug development, in this review, we provide a summary of COVID-19 and review complement's role in COVID-19 acute respiratory distress syndrome and coagulopathy.
    MeSH term(s) Animals ; Betacoronavirus/immunology ; Blood Coagulation/drug effects ; Blood Coagulation Disorders/immunology ; Blood Coagulation Disorders/virology ; COVID-19 ; Complement Activation/drug effects ; Complement Activation/physiology ; Complement Inactivating Agents/therapeutic use ; Complement System Proteins/drug effects ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/immunology ; Humans ; Inflammation/immunology ; Inflammation/virology ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/immunology ; Respiratory Distress Syndrome/virology ; SARS-CoV-2
    Chemical Substances Complement Inactivating Agents ; Complement System Proteins (9007-36-7)
    Keywords covid19
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2000644
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

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  2. Article: COVID-19: Complement, Coagulation, and Collateral Damage

    Lo, Martin W / Kemper, Claudia / Woodruff, Trent M

    J Immunol

    Abstract: ... a summary of COVID-19 and review complement's role in COVID-19 acute respiratory distress syndrome and ... that the complement system plays a key role in this inflammatory reaction. Indeed, patients with severe COVID-19 show ... with complement inhibitors all recovered with no adverse reactions. These and other studies hint at complement's ...

    Abstract Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused by the severe acute respiratory syndrome coronavirus 2. Although most people are immunocompetent to the virus, a small group fail to mount an effective antiviral response and develop chronic infections that trigger hyperinflammation. This results in major complications, including acute respiratory distress syndrome, disseminated intravascular coagulation, and multiorgan failure, which all carry poor prognoses. Emerging evidence suggests that the complement system plays a key role in this inflammatory reaction. Indeed, patients with severe COVID-19 show prominent complement activation in their lung, skin, and sera, and those individuals who were treated with complement inhibitors all recovered with no adverse reactions. These and other studies hint at complement's therapeutic potential in these sequalae, and thus, to support drug development, in this review, we provide a summary of COVID-19 and review complement's role in COVID-19 acute respiratory distress syndrome and coagulopathy.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #662455
    Database COVID19

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  3. Article ; Online: COVID-19

    Lo, Martin W. / Kemper, Claudia / Woodruff, Trent M.

    Complement, coagulation, and collateral damage

    2020  

    Abstract: ... a summary of COVID-19 and review complement's role in COVID-19 acute respiratory distress syndrome and ... that the complement system plays a key role in this inflammatory reaction. Indeed, patients with severe COVID-19 show ... with complement inhibitors all recovered with no adverse reactions. These and other studies hint at complement's ...

    Abstract Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory infection that is caused by the severe acute respiratory syndrome coronavirus 2. Although most people are immunocompetent to the virus, a small group fail to mount an effective antiviral response and develop chronic infections that trigger hyperinflammation. This results in major complications, including acute respiratory distress syndrome, disseminated intravascular coagulation, and multiorgan failure, which all carry poor prognoses. Emerging evidence suggests that the complement system plays a key role in this inflammatory reaction. Indeed, patients with severe COVID-19 show prominent complement activation in their lung, skin, and sera, and those individuals who were treated with complement inhibitors all recovered with no adverse reactions. These and other studies hint at complement's therapeutic potential in these sequalae, and thus, to support drug development, in this review, we provide a summary of COVID-19 and review complement's role in COVID-19 acute respiratory distress syndrome and coagulopathy.
    Keywords Immunology ; 2403 Immunology ; 2723 Immunology and Allergy ; covid19
    Language English
    Publishing date 2020-07-22
    Publisher American Association of Immunologists
    Publishing country au
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Update on Innate Immunity in Acute Kidney Injury-Lessons Taken from COVID-19.

    Musiał, Kinga

    International journal of molecular sciences

    2022  Volume 23, Issue 20

    Abstract: ... resident renal cells, their cytokine products, complement systems, coagulation cascades and contact systems ... through tissue collateral damage and triggers AKI. This review is an attempt to synthetize the connections ... AKI), worsening prognosis and increasing mortality. AKI in COVID-19 is above all a consequence ...

    Abstract The serious clinical course of SARS-CoV-2 infection is usually accompanied by acute kidney injury (AKI), worsening prognosis and increasing mortality. AKI in COVID-19 is above all a consequence of systemic dysregulations leading to inflammation, thrombosis, vascular endothelial damage and necrosis. All these processes rely on the interactions between innate immunity elements, including circulating blood cells, resident renal cells, their cytokine products, complement systems, coagulation cascades and contact systems. Numerous simultaneous pathways of innate immunity should secure an effective host defense. Since they all form a network of cross-linked auto-amplification loops, uncontrolled activation is possible. When the actions of selected pathways amplify, cascade activation evades control and the propagation of inflammation and necrosis worsens, accompanied by complement overactivity and immunothrombosis. The systemic activation of innate immunity reaches the kidney, where the damage affecting single tubular cells spreads through tissue collateral damage and triggers AKI. This review is an attempt to synthetize the connections between innate immunity components engaged in COVID-19-related AKI and to summarize the knowledge on the pathophysiological background of processes responsible for renal damage.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Acute Kidney Injury/complications ; Immunity, Innate ; Inflammation ; Complement System Proteins ; Necrosis ; Cytokines
    Chemical Substances Complement System Proteins (9007-36-7) ; Cytokines
    Language English
    Publishing date 2022-10-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232012514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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