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  1. Article: Liver dysfunction in COVID-19: a useful prognostic marker of severe disease?

    Lok, James / Gess, Markus

    Frontline gastroenterology

    2020  Volume 12, Issue 4, Page(s) 293–298

    Abstract: ... and prognostic markers of severe disease remain to be fully determined, although some studies have ... Background: COVID-19 is a global pandemic caused by the novel coronavirus SARS-CoV-2. Risk factors ... of COVID-19 who were admitted to Kingston Hospital in the UK. Data collected included age, sex, ethnicity ...

    Abstract Background: COVID-19 is a global pandemic caused by the novel coronavirus SARS-CoV-2. Risk factors and prognostic markers of severe disease remain to be fully determined, although some studies have suggested a correlation between abnormal liver function and adverse outcomes. Further studies are needed to investigate this further.
    Methods: This retrospective study enrolled patients with a confirmed diagnosis of COVID-19 who were admitted to Kingston Hospital in the UK. Data collected included age, sex, ethnicity, comorbidity profile, biochemical markers of liver function and the acute phase response, and overall outcome.
    Results: Between 16 March 2020 and 30 April 2020, a total of 343 patients were admitted to the acute medical team at Kingston Hospital. Excluding those with a history of liver disease, 299 patients had liver function tests performed with abnormalities demonstrated in 44.8% of individuals. Derangement of liver function was associated with greater need for ventilatory support (p<0.001), admission to high dependency unit or intensive care (p<0.001) and increased length of hospital stay (p<0.001). Of note, liver dysfunction was more common in those of non-white ethnicity (p=0.007) and correlated with higher levels of C reactive protein (p=0.01) and ferritin (p<0.001).
    Conclusion: Abnormal liver function is associated with a negative outcome among those hospitalised with COVID-19. The cause for this association is unclear, but correlation between abnormal liver function and higher serum levels of acute phase proteins suggest that dysregulation of the immune system in response to SARS-CoV-2 may be contributory.
    Language English
    Publishing date 2020-12-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2521857-8
    ISSN 2041-4137
    ISSN 2041-4137
    DOI 10.1136/flgastro-2020-101689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Liver dysfunction as a cytokine storm manifestation and prognostic factor for severe COVID-19.

    Taneva, Gergana / Dimitrov, Dimitar / Velikova, Tsvetelina

    World journal of hepatology

    2022  Volume 13, Issue 12, Page(s) 2005–2012

    Abstract: ... Furthermore, data show that liver injury can be an independent predictor of severe COVID-19, the need ... we focus on how liver dysfunction can be one of the features associated with the COVID-19 cytokine storm ... patients afflicted with COVID-19 and pathological liver biomarkers varies from 14% to 53 ...

    Abstract Liver damage in severe acute respiratory coronavirus 2 infection occurs in patients with or without preexisting liver disorders, posing a significant complication and mortality risk. During coronavirus disease 2019 (COVID-19), abnormal liver function is typically observed. However, liver injury may occur because of the treatment as well. Ischemia, cytokine storm, and hypoxia were identified as the three major factors contributing to liver damage during COVID-19. Indeed, raised liver enzymes during hospitalizations may be attributed to medications used, as well as sepsis and shock. As a result, the proportion of hospitalized patients afflicted with COVID-19 and pathological liver biomarkers varies from 14% to 53%. Aminotransferases and bilirubin are found most often elevated. Usually, increased gamma-glutamyltransferase, alkaline phosphatase, and decreased serum albumin levels are demonstrated. Additionally, although there is no specific treatment for COVID-19, many of the drugs used to treat the infection are hepatotoxic. In this mini-review, we focus on how liver dysfunction can be one of the features associated with the COVID-19 cytokine storm. Furthermore, data show that liver injury can be an independent predictor of severe COVID-19, the need for hospitalization, and death.
    Language English
    Publishing date 2022-01-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v13.i12.2005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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