Article: Pneumococcus: the sugar-coated bacteria.
International microbiology : the official journal of the Spanish Society for Microbiology
2005 Volume 9, Issue 3, Page(s) 179–190
Abstract: ... the demonstration, by genetic transformation, that genes are composed of DNA-the finding from the study of bacteria ... The study of Streptococcus pneumoniae (the pneumococcus) had been a central issue in medicine ... that has had the greatest impact on biology. Currently, pneumococcus is the most common etiologic agent ...
| Abstract | The study of Streptococcus pneumoniae (the pneumococcus) had been a central issue in medicine for many decades until the use of antibiotics became generalized. Many fundamental contributions to the history of microbiology should credit this bacterium: the capsular precipitin reaction, the major role this reaction plays in the development of immunology through the identification of polysaccharides as antigens, and, mainly, the demonstration, by genetic transformation, that genes are composed of DNA-the finding from the study of bacteria that has had the greatest impact on biology. Currently, pneumococcus is the most common etiologic agent in acute otitis media, sinusitis, and pneumonia requiring the hospitalization of adults. Moreover, meningitis is the leading cause of death among children in developing countries. Here I discuss the contributions that led to the explosion of knowledge about pneumococcus and also report some of the contributions of our group to the understanding of the molecular basis of three important virulence factors: lytic enzymes, pneumococcal phages, and the genes coding for capsular polysaccharides. |
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| MeSH term(s) | Bacterial Capsules/chemistry ; Bacteriology/history ; Drug Resistance, Bacterial ; History, 19th Century ; History, 20th Century ; Humans ; Pneumococcal Infections/microbiology ; Polysaccharides, Bacterial/biosynthesis ; Polysaccharides, Bacterial/genetics ; Streptococcus Phages/physiology ; Streptococcus pneumoniae/chemistry ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/pathogenicity ; Streptococcus pneumoniae/virology ; Virulence Factors | |||||
| Chemical Substances | Polysaccharides, Bacterial ; Virulence Factors | |||||
| Language | English | |||||
| Publishing date | 2005-11-08 | |||||
| Publishing country | Switzerland | |||||
| Document type | Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 1454951-7 | |||||
| ISSN | 1618-1905 ; 1139-6709 | |||||
| ISSN (online) | 1618-1905 | |||||
| ISSN | 1139-6709 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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