Article ; Online: Serology characteristics of SARS-CoV-2 infection after exposure and post-symptom onset.
The European respiratory journal
2020 Volume 56, Issue 2
Abstract: ... during SARS-CoV-2 infection. Serology testing provides an important complement to RNA testing ... exposure (d.p.e.) or 9, 10 and 12 days post onset (d.p.o.), respectively. The antibody levels increased ... infection is a prerequisite for treatment and prevention. The serology characteristics and complement ...
| Abstract | Background: Timely diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a prerequisite for treatment and prevention. The serology characteristics and complement diagnosis value of the antibody test to RNA test need to be demonstrated. Method: Serial sera of 80 patients with PCR-confirmed coronavirus disease 2019 (COVID-19) were collected at the First Affiliated Hospital of Zhejiang University, Hangzhou, China. Total antibody (Ab), IgM and IgG antibodies against SARS-CoV-2 were detected, and the antibody dynamics during the infection were described. Results: The seroconversion rates for Ab, IgM and IgG were 98.8%, 93.8% and 93.8%, respectively. The first detectible serology marker was Ab, followed by IgM and IgG, with a median seroconversion time of 15, 18 and 20 days post exposure (d.p.e.) or 9, 10 and 12 days post onset (d.p.o.), respectively. The antibody levels increased rapidly beginning at 6 d.p.o. and were accompanied by a decline in viral load. For patients in the early stage of illness (0-7 d.p.o), Ab showed the highest sensitivity (64.1%) compared with IgM and IgG (33.3% for both; p<0.001). The sensitivities of Ab, IgM and IgG increased to 100%, 96.7% and 93.3%, respectively, 2 weeks later. When the same antibody type was detected, no significant difference was observed between enzyme-linked immunosorbent assays and other forms of immunoassays. Conclusions: A typical acute antibody response is induced during SARS-CoV-2 infection. Serology testing provides an important complement to RNA testing in the later stages of illness for pathogenic-specific diagnosis and helpful information to evaluate the adapted immunity status of patients. |
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| MeSH term(s) | Adult ; Aged ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; China ; Clinical Laboratory Techniques ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Female ; Hospitalization ; Humans ; Infectious Disease Incubation Period ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; SARS-CoV-2 ; Sensitivity and Specificity ; Seroconversion ; Symptom Assessment ; Time Factors ; Viral Load |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-08-27 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 639359-7 |
| ISSN | 1399-3003 ; 0903-1936 |
| ISSN (online) | 1399-3003 |
| ISSN | 0903-1936 |
| DOI | 10.1183/13993003.00763-2020 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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