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Article ; Online: Upper airway symptoms in coronavirus disease 2019 (COVID-19).

Lovato, Andrea / de Filippis, Cosimo / Marioni, Gino

2020 Volume 41, Issue 3, Page(s) 102474

MeSH term(s)	COVID-19 ; Communicable Disease Control ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/epidemiology ; Female ; Global Health ; Humans ; Incidence ; Male ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/epidemiology ; Respiratory Tract Infections/diagnosis ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; Risk Assessment ; SARS Virus/pathogenicity
Keywords	covid19
Language	English
Publishing date	2020-04-04
Publishing country	United States
Document type	Letter
ZDB-ID	604541-8
ISSN	1532-818X ; 0196-0709
ISSN (online)	1532-818X
ISSN	0196-0709
DOI	10.1016/j.amjoto.2020.102474
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Article: Upper airway symptoms in coronavirus disease 2019 (COVID-19)

Lovato, Andrea / de Filippis, Cosimo / Marioni, Gino

Am J Otolaryngol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #30780
Database	COVID19

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Article ; Online: Upper airway symptoms in Coronavirus Disease 2019 (COVID-19)

Lovato, A / de Filippis, C / Marioni, G.

2020

Keywords	covid19
Language	English
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Upper airway symptoms in coronavirus disease 2019 (COVID-19)

Lovato, Andrea / de Filippis, Cosimo / Marioni, Gino

American Journal of Otolaryngology

2020 Volume 41, Issue 3, Page(s) 102474

Keywords	Otorhinolaryngology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	604541-8
ISSN	0196-0709
ISSN	0196-0709
DOI	10.1016/j.amjoto.2020.102474
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Uncover a microbiota signature of upper respiratory tract in patients with SARS-CoV-2 + .

Bellato, Massimo / Cappellato, Marco / Longhin, Francesca / Del Vecchio, Claudia / Brancaccio, Giuseppina / Cattelan, Anna Maria / Brun, Paola / Salaris, Claudio / Castagliuolo, Ignazio / Di Camillo, Barbara

Scientific reports

2023 Volume 13, Issue 1, Page(s) 16867

Abstract: The outbreak of Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, forced us to face ... going to experience the more severe outcomes of COVID-19 is still a major need, to focus therapeutic ... with nasopharyngeal swab positive for SARS-CoV-2. Patients were divided into groups based on the presence of symptoms ...

Abstract	The outbreak of Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, forced us to face a pandemic with unprecedented social, economic, and public health consequences. Several nations have launched campaigns to immunize millions of people using various vaccines to prevent infections. Meanwhile, therapeutic approaches and discoveries continuously arise; however, identifying infected patients that are going to experience the more severe outcomes of COVID-19 is still a major need, to focus therapeutic efforts, reducing hospitalization and mitigating drug adverse effects. Microbial communities colonizing the respiratory tract exert significant effects on host immune responses, influencing the susceptibility to infectious agents. Through 16S rDNAseq we characterized the upper airways' microbiota of 192 subjects with nasopharyngeal swab positive for SARS-CoV-2. Patients were divided into groups based on the presence of symptoms, pneumonia severity, and need for oxygen therapy or intubation. Indeed, unlike most of the literature, our study focuses on identifying microbial signatures predictive of disease progression rather than on the probability of infection itself, for which a consensus is lacking. Diversity, differential abundance, and network analysis at different taxonomic levels were synergistically adopted, in a robust bioinformatic pipeline, highlighting novel possible taxa correlated with patients' disease progression to intubation.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 ; Microbiota ; Disease Outbreaks ; Disease Progression
Language	English
Publishing date	2023-10-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-43040-x
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Article ; Online: Upper airway dimensions and the skeletal parameters in orthodontic patients who developed moderate-severe COVID-19 symptoms during the pandemic.

Al Maaitah, Emad Farhan / Al-Musfir, Tumadher Mohammed / Abed Al Jawad, Feras / Alhashimi, Najah / Abu Alhaija, Elham Saleh

Dental and medical problems

2023 Volume 60, Issue 1, Page(s) 13–22

Abstract: ... for coronavirus disease 2019 (COVID-19) may be associated with the severity of COVID-19 symptoms.: Objectives ... and the upper airway dimensions with the severity of COVID-19 symptoms in adult subjects.: Material ... in patients who tested positive for COVID-19, to compare the upper airway dimensions and the craniofacial ...

Abstract	Background: Large airway dimensions are associated with a rapid decline in the lung function and a higher risk of hospitalization. Therefore, the airway dimensions of healthy subjects who tested positive for coronavirus disease 2019 (COVID-19) may be associated with the severity of COVID-19 symptoms. Objectives: The objectives of this study were to measure the upper airway dimensions and the craniofacial skeletal parameters in patients who tested positive for COVID-19, to compare the upper airway dimensions and the craniofacial skeletal parameters between patients who developed no/mild symptoms and those with moderate-severe COVID-19 symptoms, and to assess any association of the skeletal relationships (anteroposterior (AP) and vertical) and the upper airway dimensions with the severity of COVID-19 symptoms in adult subjects. Material and methods: A total of 204 orthodontic patients who tested positive for COVID-19 were evaluated. Of these, only 137 met the inclusion criteria. The sample was further subdivided into 2 groups based on the severity of symptoms: cases (moderate-severe symptoms; n = 56); and controls (asymptomatic/ mild symptoms; n = 81). The upper airway dimensions and the skeletal parameters were measured on lateral cephalograms. The nonparametric Mann-Whitney U test was used to detect differences between the cases and the controls. Binary logistic regression analysis was used to evaluate the association between the studied variables and the severity of symptoms. Results: The cases had a reduced lower face height (LFH) and a reduced perpendicular distance from the hyoid bone to the line connecting the anteroinferior limit of the 3rd cervical vertebra (C3) and the retrognathion point (RGN) (HH1) as compared to the controls. Regression analysis revealed a significant association of LFH (p = 0.013), the vertical airway length (VAL) (p = 0.002) and HH1 (p = 0.021) with the severity of COVID-19 symptoms. Conclusions: The types of malocclusion were similar in the cases and the controls. Patients with reduced LFH and VAL, and a superiorly positioned hyoid bone in relation to the mandible developed more severe COVID-19 symptoms.
MeSH term(s)	Adult ; Humans ; Pharynx ; Pandemics ; Cephalometry/methods ; COVID-19 ; Malocclusion/diagnostic imaging
Language	English
Publishing date	2023-02-10
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2592057-1
ISSN	2300-9020 ; 2300-9020
ISSN (online)	2300-9020
ISSN	2300-9020
DOI	10.17219/dmp/157457
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Article ; Online: Uncover a microbiota signature of upper respiratory tract in patients with SARS-CoV-2 +

Massimo Bellato / Marco Cappellato / Francesca Longhin / Claudia Del Vecchio / Giuseppina Brancaccio / Anna Maria Cattelan / Paola Brun / Claudio Salaris / Ignazio Castagliuolo / Barbara Di Camillo

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract The outbreak of Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, forced ... that are going to experience the more severe outcomes of COVID-19 is still a major need, to focus ... on the presence of symptoms, pneumonia severity, and need for oxygen therapy or intubation. Indeed, unlike most ...

Abstract	Abstract The outbreak of Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, forced us to face a pandemic with unprecedented social, economic, and public health consequences. Several nations have launched campaigns to immunize millions of people using various vaccines to prevent infections. Meanwhile, therapeutic approaches and discoveries continuously arise; however, identifying infected patients that are going to experience the more severe outcomes of COVID-19 is still a major need, to focus therapeutic efforts, reducing hospitalization and mitigating drug adverse effects. Microbial communities colonizing the respiratory tract exert significant effects on host immune responses, influencing the susceptibility to infectious agents. Through 16S rDNAseq we characterized the upper airways’ microbiota of 192 subjects with nasopharyngeal swab positive for SARS-CoV-2. Patients were divided into groups based on the presence of symptoms, pneumonia severity, and need for oxygen therapy or intubation. Indeed, unlike most of the literature, our study focuses on identifying microbial signatures predictive of disease progression rather than on the probability of infection itself, for which a consensus is lacking. Diversity, differential abundance, and network analysis at different taxonomic levels were synergistically adopted, in a robust bioinformatic pipeline, highlighting novel possible taxa correlated with patients’ disease progression to intubation.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Association of Upper Respiratory Streptococcus pneumoniae Colonization With Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Adults.

Parker, Anna M / Jackson, Nicole / Awasthi, Shevya / Kim, Hanna / Alwan, Tess / Wyllie, Anne L / Baldwin, Alisha B / Brennick, Nicole B / Moehle, Erica A / Giannikopoulos, Petros / Kogut, Katherine / Holland, Nina / Mora-Wyrobek, Ana / Eskenazi, Brenda / Riley, Lee W / Lewnard, Joseph A

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2022 Volume 76, Issue 7, Page(s) 1209–1217

Abstract: ... the association of SARS-CoV-2 infection with recent exposure to a suspected coronavirus disease 2019 case (aOR, 7 ... in the upper airway. It is unclear whether similar interactions occur with severe acute respiratory syndrome ... suggest a synergistic relationship in the upper airway. Longitudinal studies are needed to determine ...

Abstract	Background: Streptococcus pneumoniae interacts with numerous viral respiratory pathogens in the upper airway. It is unclear whether similar interactions occur with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: We collected saliva specimens from working-age adults undergoing SARS-CoV-2 molecular testing at outpatient clinics and via mobile community-outreach testing between July and November 2020 in Monterey County, California. After bacterial culture enrichment, we tested for pneumococci by means of quantitative polymerase chain reaction targeting the lytA and piaB genes, and we measured associations with SARS-CoV-2 infection using conditional logistic regression. Results: Analyses included 1278 participants, with 564 enrolled in clinics and 714 enrolled through outreach-based testing. The prevalence of pneumococcal carriage was 9.2% (117 of 1278) among all participants (11.2% [63 of 564] in clinic-based testing and 7.6% [54 of 714] in outreach-based testing). The prevalence of SARS-CoV-2 infection was 27.4% (32 of 117) among pneumococcal carriers and 9.6% (112 of 1161) among noncarriers (adjusted odds ratio [aOR], 2.73 [95% confidence interval (CI): 1.58-4.69). Associations between SARS-CoV-2 infection and pneumococcal carriage were enhanced in the clinic-based sample (aOR, 4.01 [95% CI: 2.08-7.75]) and among symptomatic participants (3.38 [1.35-8.40]), compared with findings within the outreach-based sample and among asymptomatic participants. The adjusted odds of SARS-CoV-2 coinfection increased 1.24-fold (95% CI: 1.00-1.55-fold) for each 1-unit decrease in piaB quantitative polymerase chain reaction cycle threshold value among pneumococcal carriers. Finally, pneumococcal carriage modified the association of SARS-CoV-2 infection with recent exposure to a suspected coronavirus disease 2019 case (aOR, 7.64 [95% CI: 1.91-30.7] and 3.29 [1.94-5.59]) among pneumococcal carriers and noncarriers, respectively). Conclusions: Associations of pneumococcal carriage detection and density with SARS-CoV-2 suggest a synergistic relationship in the upper airway. Longitudinal studies are needed to determine interaction mechanisms between pneumococci and SARS-CoV-2.
MeSH term(s)	Humans ; Adult ; Streptococcus pneumoniae/genetics ; COVID-19/epidemiology ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/microbiology ; Nasopharynx/microbiology ; SARS-CoV-2
Language	English
Publishing date	2022-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciac907
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Article ; Online: Clinical Presentation of COVID-19: A Systematic Review Focusing on Upper Airway Symptoms.

Lovato, Andrea / de Filippis, Cosimo

Ear, nose, & throat journal

2020 Volume 99, Issue 9, Page(s) 569–576

Abstract: ... the presenting symptoms of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome ... of COVID-19, focusing on upper airway symptoms in order to help otolaryngologists identifying suspected ... olfactory, and gustative disorders could be the presenting symptoms of COVID-19. Clinical presentation ...

Abstract	Aim: Pharyngodynia, nasal congestion, rhinorrhea, smell, and taste dysfunctions could be the presenting symptoms of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2. The aim was to perform a systematic review of current evidences on clinical presentation of COVID-19, focusing on upper airway symptoms in order to help otolaryngologists identifying suspected cases. Methods: We searched PubMed and Web of Science electronic databases. Results: We included 5 retrospective clinical studies for a total of 1556 hospitalized patients with COVID-19, 57.5% were male and mean age was 49.1 years. Pooled data revealed that pharyngodynia was present in 12.4% of patients, nasal congestion in 3.7%, and rhinorrhea was rare. No reports on COVID-19 and olfactory/gustative disorders matched inclusion criteria but preliminary evidences suggested they could be present. Common symptoms were fever (85.6%), cough (68.7%), and fatigue (39.4%). Frequent comorbidities were hypertension (17.4%), diabetes (3.8%), and coronary heart disease (3.8%); 83% of patients had alterations on chest computed tomography that were bilateral in 89.5% of cases. Ground-glass opacity was the most common finding (50%). Lymphopenia (77.2%) and leucopenia (30.1%) were common. Critical cases with complications were 9%, intensive care unit admission was required in 7.3%, invasive ventilation in 3.4%, and mortality was 2.4%. Conclusion: Otolaryngologists should know that pharyngodynia, nasal congestion, olfactory, and gustative disorders could be the presenting symptoms of COVID-19. Clinical presentation together with radiological and laboratory findings could help to identify suspected cases.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/physiopathology ; Cough/physiopathology ; Fatigue/physiopathology ; Fever/physiopathology ; Humans ; Leukopenia/blood ; Leukopenia/physiopathology ; Lung/diagnostic imaging ; Lymphopenia/blood ; Lymphopenia/physiopathology ; Olfaction Disorders/physiopathology ; Pandemics ; Pharyngitis/physiopathology ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/physiopathology ; SARS-CoV-2 ; Taste Disorders/physiopathology ; Tomography, X-Ray Computed
Keywords	covid19
Language	English
Publishing date	2020-04-13
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	750153-5
ISSN	1942-7522 ; 0145-5613
ISSN (online)	1942-7522
ISSN	0145-5613
DOI	10.1177/0145561320920762
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Article: Upper respiratory tract and otolaryngological manifestations of coronavirus disease 2019 (COVID-19): A systemic review.

Al-Swiahb, Jamil N / Motiwala, Mohammed A

SAGE open medicine

2021 Volume 9, Page(s) 20503121211016965

Abstract: ... using the following keywords: COVID-19, clinical features, characteristics, symptoms, clinical ... manifestations, throat, cough, rhinorrhea, COVID-19 anosmia, headache, nasal, coronavirus, and coronavirus ... and headache (3%-16.2%) were the most common symptoms reported. Our findings confirm that coronavirus ...

Abstract	To detect, analyze, and discuss the different ear nose throat manifestations, those were reported in coronavirus disease-positive patients in the published and reviewed literature. Coronavirus disease has been reported to present with several symptoms. Common symptoms include new onset of fever, cough, fatigue, and myalgia. Other symptoms like sputum production, dyspnea, rhinorrhea, anosmia, nasal stuffiness, headache, and sore throat are less frequently reported, but the clinical presentation is highly variable among individuals. We review the otolaryngologic manifestations of coronavirus disease reported in the published literature to assess its importance in the early diagnosis of coronavirus disease. We searched PubMed database, MEDLINE, Web of Science, LILACS, SciELO, and Cochrane Library to find out relevant articles, using the following keywords: COVID-19, clinical features, characteristics, symptoms, clinical, manifestations, throat, cough, rhinorrhea, COVID-19 anosmia, headache, nasal, coronavirus, and coronavirus otolaryngologic. Article selection was based on their relevance to the research question. Totally, 14 articles and 2971 patients were recruited for our study. A wide variety of upper and lower airway manifestations were reported. Fever (34%-96.5%), cough (17.9%-83%), myalgia or fatigue (10%-31%), expectoration (20%-32.7%), dyspnea (7.6%-7.5%), rhinorrhea (1%-6.8%), sore throat (4%-61%), nasal congestion (3%-4.8%), and headache (3%-16.2%) were the most common symptoms reported. Our findings confirm that coronavirus disease infection presents with a wide spectrum of clinical presentation. The ear nose throat manifestations for coronavirus disease are not uncommon, but more attention should also be paid to patients with otolaryngologic symptoms which can appear early, as this could encourage an earlier diagnosis and treatment, which limits spread of the disease.
Language	English
Publishing date	2021-05-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2735399-0
ISSN	2050-3121
ISSN	2050-3121
DOI	10.1177/20503121211016965
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