Article ; Online: Effects of CD20+ B-cell infiltration into allografts on kidney transplantation outcomes: a systematic review and meta-analysis.
2017 Volume 8, Issue 23, Page(s) 37935–37941
Abstract: The effects of CD20+ B-cell infiltration during acute rejection on graft outcomes are controversial ... who experienced kidney graft rejection. In conclusion, CD 20+ B cell infiltration during allograft rejection was ... with graft loss and steroid resistance. No association of CD20+ B-cell infiltration with C4d-positive ...
| Abstract | The effects of CD20+ B-cell infiltration during acute rejection on graft outcomes are controversial. The objective of this systematic review and meta-analysis was to clarify this issue. We performed a systematic literature search for studies published up to January 14, 2016. A total of 5 studies, with 200 patients, were included. The presence of CD20+ B cells in renal biopsies during allograft rejection was associated with graft loss and steroid resistance. No association of CD20+ B-cell infiltration with C4d-positive staining of the peritubular capillaries in renal biopsies was found in the analysis of patients who experienced kidney graft rejection. In conclusion, CD 20+ B cell infiltration during allograft rejection was associated with an increased risk of graft loss and steroid resistance. |
|---|---|
| Language | English |
| Publishing date | 2017-06-06 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 2560162-3 |
| ISSN | 1949-2553 ; 1949-2553 |
| ISSN (online) | 1949-2553 |
| ISSN | 1949-2553 |
| DOI | 10.18632/oncotarget.16229 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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