LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 1 of total 1

Search options

Article: Claudins in intestines: Distribution and functional significance in health and diseases.

Lu, Zhe / Ding, Lei / Lu, Qun / Chen, Yan-Hua

Tissue barriers

2013  Volume 1, Issue 3, Page(s) e24978

Abstract: ... their distribution and localization in the intestinal tract of mammals, their alterations in intestine-related ... diseases and chemicals/agents that regulate the expression and localization of claudins as well ... to systemic organ failure. Claudins are the major structural and functional components of TJs with at least 24 ...

Abstract Intestines are organs that not only digest food and absorb nutrients, but also provide a defense barrier against pathogens and noxious agents ingested. Tight junctions (TJs) are the most apical component of the junctional complex, providing one form of cell-cell adhesion in enterocytes and playing a critical role in regulating paracellular barrier permeability. Alteration of TJs leads to a number of pathophysiological diseases causing malabsorption of nutrition and intestinal structure disruption, which may even contribute to systemic organ failure. Claudins are the major structural and functional components of TJs with at least 24 members in mammals. Claudins have distinct charge-selectivity, either by tightening the paracellular pathway or functioning as paracellular channels, regulating ions and small molecules passing through the paracellular pathway. In this review, we have discussed the functions of claudin family members, their distribution and localization in the intestinal tract of mammals, their alterations in intestine-related diseases and chemicals/agents that regulate the expression and localization of claudins as well as the intestinal permeability, which provide a therapeutic view for treating intestinal diseases.
Language English
Publishing date 2013-05-30
Publishing country United States
Document type Journal Article ; Review
ISSN 2168-8362
ISSN 2168-8362
DOI 10.4161/tisb.24978
Database MEDical Literature Analysis and Retrieval System OnLINE

More links

Kategorien

To top