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Article ; Online: Guillain-Barré syndrome, SARS-CoV-2 and molecular mimicry.

Lucchese, Guglielmo / Flöel, Agnes

2021 Volume 144, Issue 5, Page(s) e43

MeSH term(s)	COVID-19 ; Guillain-Barre Syndrome ; Humans ; Molecular Mimicry ; SARS-CoV-2
Language	English
Publishing date	2021-04-06
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awab067
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Article ; Online: SARS-CoV-2 and Guillain-Barré syndrome: molecular mimicry with human heat shock proteins as potential pathogenic mechanism.

Lucchese, Guglielmo / Flöel, Agnes

Cell stress & chaperones

2020 Volume 25, Issue 5, Page(s) 731–735

Abstract: ... heat shock proteins 90 and 60, which are associated with Guillain-Barré syndrome and other autoimmune diseases ... with immune-mediated polyneuropathies. Our results show molecular mimicry between the virus and human ... with Guillain-Barré syndrome. We investigated here the potential mechanism underlying the virus-induced damage ...

Abstract	Severe acute respiratory syndrome-related coronavirus 2 infection has been associated with Guillain-Barré syndrome. We investigated here the potential mechanism underlying the virus-induced damage of the peripheral nervous systems by searching the viral amino acid sequence for peptides common to human autoantigens associated with immune-mediated polyneuropathies. Our results show molecular mimicry between the virus and human heat shock proteins 90 and 60, which are associated with Guillain-Barré syndrome and other autoimmune diseases. Crucially, the shared peptides are embedded in immunoreactive epitopes that have been experimentally validated in the human host.
MeSH term(s)	Amino Acid Sequence ; Autoantigens ; Betacoronavirus/metabolism ; COVID-19 ; Chaperonin 60/chemistry ; Chaperonin 60/immunology ; Coronavirus Infections/virology ; Databases, Protein ; Guillain-Barre Syndrome/metabolism ; HSP90 Heat-Shock Proteins/chemistry ; HSP90 Heat-Shock Proteins/immunology ; Humans ; Immunodominant Epitopes ; Mitochondrial Proteins/chemistry ; Mitochondrial Proteins/immunology ; Molecular Mimicry ; Pandemics ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Viral Proteins/chemistry ; Viral Proteins/immunology
Chemical Substances	Autoantigens ; Chaperonin 60 ; HSP90 Heat-Shock Proteins ; HSP90AB1 protein, human ; HSPD1 protein, human ; Immunodominant Epitopes ; Mitochondrial Proteins ; Viral Proteins
Keywords	covid19
Language	English
Publishing date	2020-07-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1362749-1
ISSN	1466-1268 ; 1355-8145
ISSN (online)	1466-1268
ISSN	1355-8145
DOI	10.1007/s12192-020-01145-6
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Article ; Online: Reply: Guillain-Barré syndrome, SARS-CoV-2 and molecular mimicry and Ongoing challenges in unravelling the association between COVID-19 and Guillain-Barré syndrome and Unclear association between COVID-19 and Guillain-Barré syndrome and Currently available data regarding the potential association between COVID-19 and Guillain-Barré syndrome.

Lunn, Michael P / Carr, Aisling C / Keddie, Stephen / Pakpoor, Julia / Pipis, Menelaos / Willison, Hugh J

Brain : a journal of neurology

2021 Volume 144, Issue 5, Page(s) e47

MeSH term(s)	COVID-19 ; Guillain-Barre Syndrome ; Humans ; Longitudinal Studies ; Molecular Mimicry ; SARS-CoV-2
Language	English
Publishing date	2021-04-06
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awab070
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Article: SARS-CoV-2 and Guillain-Barré syndrome: molecular mimicry with human heat shock proteins as potential pathogenic mechanism

Lucchese, Guglielmo / Flöel, Agnes

Cell Stress Chaperones

Abstract	Severe acute respiratory syndrome-related coronavirus 2 infection has been associated with Guillain-Barré syndrome. We investigated here the potential mechanism underlying the virus-induced damage of the peripheral nervous systems by searching the viral amino acid sequence for peptides common to human autoantigens associated with immune-mediated polyneuropathies. Our results show molecular mimicry between the virus and human heat shock proteins 90 and 60, which are associated with Guillain-Barré syndrome and other autoimmune diseases. Crucially, the shared peptides are embedded in immunoreactive epitopes that have been experimentally validated in the human host.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #784851
Database	COVID19

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Article ; Online: COVID-19 as a trigger of Guillain-Barré syndrome: A review of the molecular mechanism.

Malekpour, Mahdi / Khanmohammadi, Shaghayegh / Meybodi, Mohammad Javad Entezari / Shekouh, Dorsa / Rahmanian, Mohammad Reza / Kardeh, Sina / Azarpira, Negar

Immunity, inflammation and disease

2023 Volume 11, Issue 5, Page(s) e875

Abstract: ... systems. One of the PACSs after SARS-CoV-2 infection and vaccination is Guillain-Barré syndrome (GBS ... Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a pandemic with serious ... patients. SARS-CoV-2 can trigger GBS via several pathways like direct neurotropism and neurovirulence ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a pandemic with serious complications. After coronavirus disease 2019 (COVID-19), several post-acute COVID-19 syndromes (PACSs) and long-COVID sequels were reported. PACSs involve many organs, including the nervous, gustatory, and immune systems. One of the PACSs after SARS-CoV-2 infection and vaccination is Guillain-Barré syndrome (GBS). The incidence rate of GBS after SARS-CoV-2 infection or vaccination is low. However, the high prevalence of COVID-19 and severe complications of GBS, for example, autonomic dysfunction and respiratory failure, highlight the importance of post-COVID-19 GBS. It is while patients with simultaneous COVID-19 and GBS seem to have higher admission rates to the intensive care unit, and demyelination is more aggressive in post-COVID-19 GBS patients. SARS-CoV-2 can trigger GBS via several pathways like direct neurotropism and neurovirulence, microvascular dysfunction and oxidative stress, immune system disruption, molecular mimicry, and autoantibody production. Although there are few molecular studies on the molecular and cellular mechanisms of GBS occurrence after SARS-CoV-2 infection and vaccination, we aimed to discuss the possible pathomechanism of post-COVID-19 GBS by gathering the most recent molecular evidence.
MeSH term(s)	Humans ; COVID-19/complications ; SARS-CoV-2 ; Guillain-Barre Syndrome/etiology ; Guillain-Barre Syndrome/complications ; Post-Acute COVID-19 Syndrome ; Pandemics
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2740382-8
ISSN	2050-4527 ; 2050-4527
ISSN (online)	2050-4527
ISSN	2050-4527
DOI	10.1002/iid3.875
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Article ; Online: Guillain-Barré syndrome associated with COVID-19 infection

Muhammad Hafiz Aini / Rakhmad Hidayat / Nita Widjaya / Fhathia Avisha / Heydi Marizky Lisman / Devi Nurfadila Fani

Romanian Journal of Neurology, Vol 22, Iss 3, Pp 261-

A case report

2023 Volume 264

Abstract: ... with Guillain-Barré Syndrome in this case report. Guillain-Barre Syndrome (GBS) is an inflammatory polyradiculoneuropathy ... Coronavirus 2 or SARS-CoV-2 is predominantly manifests as a respiratory infection; however, it has ... with its pathogenesis intricately influenced by the pivotal role of molecular mimicry in its onset. Plasmapheresis was ...

Abstract	Coronavirus 2 or SARS-CoV-2 is predominantly manifests as a respiratory infection; however, it has been linked to a spectrum of neurological disorders such as vertigo, cephalalgia, cognitive impairment, myalgia, and anosmia. Emerging reports indicate several neurological illnesses that coincide with COVID-19, such as encephalitis and, notably, stroke. In this report, We present an instance of a patient infected with COVID-19 with Guillain-Barré Syndrome in this case report. Guillain-Barre Syndrome (GBS) is an inflammatory polyradiculoneuropathy linked to various viral infections. We present the case of a 76-year-old female patient hospitalized with acute progressive symmetric ascending quadriparesis. Seven days before hospitalization, the patient experienced fever and cough with RT-PCR testing confirmed a positive COVID-19 infection. Cerebrospinal fluid analysis revealed dissociation of cytoalbumin. Coronavirus stimulates inflammatory cells and produces various cytokines, leading to immune-mediated processes. GBS represents an immune-mediated disorder, with its pathogenesis intricately influenced by the pivotal role of molecular mimicry in its onset. Plasmapheresis was performed, resulting in an improved clinical outcome for the patient.
Keywords	guillain-barré syndrome ; covid-19 ; plasmapharesis ; neurology ; coronavirus ; intensive care ; Medicine ; R ; Neurology. Diseases of the nervous system ; RC346-429
Subject code	616
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Amaltea Medical Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Getting paralysed after COVID: Guillain-Barre syndrome.

Mehta, Sameer K / Sunder, Ashok

Journal of family medicine and primary care

2021 Volume 10, Issue 7, Page(s) 2706–2708

Abstract: ... nausea, vomiting, dizziness, and myalgia. Guillain-Barre syndrome (GBS) is a rare manifestation ... of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection; whereas the common neurological manifestations of the SARS ... CoV-2 infection occur with the onset of the respiratory symptoms and may be due to the direct invasion ...

Abstract	Neurological involvement after coronavirus disease (COVID-19) pneumonias is common and occurs in almost one-third of the patients. The commonest neurological symptoms are ageusia, anosmia, headache, nausea, vomiting, dizziness, and myalgia. Guillain-Barre syndrome (GBS) is a rare manifestation of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection; whereas the common neurological manifestations of the SARS-CoV-2 infection occur with the onset of the respiratory symptoms and may be due to the direct invasion of the nervous system by the virus, GBS in COVID-19 follows a time lag of 1-4 weeks and may be attributable to the immune mechanism of molecular mimicry. Here we report a case of GBS in a patient of COVID-19 which occurred on the 22
Language	English
Publishing date	2021-07-30
Publishing country	India
Document type	Case Reports
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_2454_20
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Article: Guillain-Barré Syndrome in the COVID-19 Pandemic.

Tawakul, Abdullah Ahmad / Al-Doboke, Amal Waleed / Altayyar, Shahad Ali / Alsulami, Seham Abdulhafith / Alfahmi, Ahlam Musallam / Nooh, Raghad Turki

Neurology international

2021 Volume 14, Issue 1, Page(s) 34–48

Abstract: There have been several reported cases of severe acute respiratory syndrome (SARS-CoV-2) infection ... SARS-CoV-2 and human autoantigens. ... associated with COVID-19 and immune-mediated neurological complications, which is molecular mimicry between ...

Abstract	There have been several reported cases of severe acute respiratory syndrome (SARS-CoV-2) infection that were associated with an increased incidence of neurological manifestations, including Guillain-Barré syndrome (GBS). This review aims to present information on the reports of GBS associated with coronavirus disease 2019 (COVID-19) infection. Our review is retrospective work examining articles published from the 1 April 2020 to the 8 May 2021 in the English language. We used the diagnostic criteria and classification published by the National Institute of Neurological Disorders and Stroke and Brighton Collaboration. GBS is usually a postinfectious syndrome, but GBS in the COVID-19 pandemic also takes on a para-infectious profile. In the reports, the genetic factor has a role in developing GBS in some patients. In conclusion, the association between COVID-19 and GBS is not very clear. Still, one mechanism is strongly associated with COVID-19 and immune-mediated neurological complications, which is molecular mimicry between SARS-CoV-2 and human autoantigens.
Language	English
Publishing date	2021-12-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2514727-4
ISSN	2035-8377 ; 2035-8385
ISSN (online)	2035-8377
ISSN	2035-8385
DOI	10.3390/neurolint14010003
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Article: Emerging Infection, Vaccination, and Guillain-Barré Syndrome: A Review.

Koike, Haruki / Chiba, Atsuro / Katsuno, Masahisa

Neurology and therapy

2021 Volume 10, Issue 2, Page(s) 523–537

Abstract: ... COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have also been ... a similarity of Zika virus and SARS-CoV-2 proteins to human proteins has been suggested. With the development ... Guillain-Barré syndrome (GBS) is an autoimmune disorder of the peripheral nervous system ...

Abstract	Guillain-Barré syndrome (GBS) is an autoimmune disorder of the peripheral nervous system that typically develops within 4 weeks after infection. In addition to conventional infectious diseases with which we are familiar, emerging infectious diseases, such as Zika virus infection and coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have also been suggested to be associated with GBS. GBS is mainly categorized into a demyelinating subtype known as acute inflammatory demyelinating polyneuropathy (AIDP) and an axonal subtype known as acute motor axonal neuropathy (AMAN). Most patients who develop GBS after Zika virus infection or COVID-19 have AIDP. The concept of molecular mimicry between pathogens and human peripheral nerve components was established through studies of AMAN with anti-ganglioside GM1 antibodies occurring after Campylobacter jejuni infection. Although such mimicry between specific pathogens and myelin or Schwann cell components has not been clearly demonstrated in AIDP, a similarity of Zika virus and SARS-CoV-2 proteins to human proteins has been suggested. With the development of global commerce and travel, emerging infectious diseases will continue to threaten public health. From this viewpoint, the development of vaccines and antiviral drugs is important to prepare for and control emerging infectious diseases. Although a decrease in the number of patients after the 2015-2016 Zika epidemic increased the difficulty in conducting phase 3 trials for Zika virus vaccines, the efficacy and safety of new vaccines have recently been demonstrated for COVID-19. In general, vaccines can decrease the risk of infectious disease by stimulating the immune system, and discussions regarding an increased risk of autoimmune disorders, such as GBS, have been ongoing for many years. However, the risk of GBS is not considered a legitimate reason to limit the administration of currently available vaccines, as only a trivial association or no association with GBS has been demonstrated.
Language	English
Publishing date	2021-06-12
Publishing country	New Zealand
Document type	Journal Article ; Review
ISSN	2193-8253
ISSN	2193-8253
DOI	10.1007/s40120-021-00261-4
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Article ; Online: Guillain-Barré Syndrome in the COVID-19 Pandemic

Abdullah Ahmad Tawakul / Amal Waleed Al-Doboke / Shahad Ali Altayyar / Seham Abdulhafith Alsulami / Ahlam Musallam Alfahmi / Raghad Turki Nooh

Neurology International, Vol 14, Iss 3, Pp 34-

2021 Volume 48

Abstract	There have been several reported cases of severe acute respiratory syndrome (SARS-CoV-2) infection that were associated with an increased incidence of neurological manifestations, including Guillain–Barré syndrome (GBS). This review aims to present information on the reports of GBS associated with coronavirus disease 2019 (COVID-19) infection. Our review is retrospective work examining articles published from the 1 April 2020 to the 8 May 2021 in the English language. We used the diagnostic criteria and classification published by the National Institute of Neurological Disorders and Stroke and Brighton Collaboration. GBS is usually a postinfectious syndrome, but GBS in the COVID-19 pandemic also takes on a para-infectious profile. In the reports, the genetic factor has a role in developing GBS in some patients. In conclusion, the association between COVID-19 and GBS is not very clear. Still, one mechanism is strongly associated with COVID-19 and immune-mediated neurological complications, which is molecular mimicry between SARS-CoV-2 and human autoantigens.
Keywords	Guillain–Barré syndrome ; GBS ; SARS-CoV-2 ; COVID-19 ; SARS ; Medicine ; R ; Internal medicine ; RC31-1245 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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