Article ; Online: Clinical characteristics and outcomes of 2019 novel coronavirus disease patients presenting with initial gastrointestinal symptoms in Wuhan, China: A retrospective cohort study.
Journal of gastroenterology and hepatology
2020 Volume 36, Issue 3, Page(s) 694–699
Abstract: Background and aim: Patients with 2019 novel coronavirus disease (COVID-19) could present ... clinical characteristics and outcomes, when compared with patients with fever and respiratory symptoms. ... with initial gastrointestinal symptoms (group A, n = 183) and patients with respiratory syndrome and/or fever ...
| Abstract | Background and aim: Patients with 2019 novel coronavirus disease (COVID-19) could present with gastrointestinal symptoms without fever or respiratory manifestations, which could be overlooked by health-care providers. We aimed to evaluate the clinical characteristics of COVID-19 in patients presenting with initial gastrointestinal symptoms. Methods: We evaluated all confirmed cases of COVID-19 in Zhongnan Hospital of Wuhan University between January 10 and February 29, 2020. We divided these patients into two groups: patients with initial gastrointestinal symptoms (group A, n = 183) and patients with respiratory syndrome and/or fever (group B, n = 1228). The clinical characteristics, radiological features, and laboratory data were assessed. Results: The clinical procedures of both groups underwent 1-2 weeks rising period and were downward trend at 3 weeks; less than 5% of patients progressed to critical illness. In both groups, mean leukocyte count (P = 0.354) and lymphocyte count (P = 0.386) were below normal, and C-reactive protein level was elevated (P = 0.412). There was mild liver function injury (aspartate aminotransferase, 65.8 ± 12.7 vs 67.4 ± 9.3 U/L, P = 0.246; alanine aminotransferase, 66.4 ± 13.2 vs 69.6 ± 12.7 U/L, P = 0.352), and normal renal function was intact (blood urea nitrogen 6.4 ± 2.5 vs 5.6 ± 2.8 mmol/L P = 0.358; creatinine 85.7 ± 37.2, 91.2 ± 32.6 μmol/L, P = 0.297). After a series of treatment, 176 and 1169 were stable and alive in groups A and B, respectively. The survival rate did not differ significantly between the groups (P = 0.313). Conclusion: COVID-19 patients presented with initial gastrointestinal symptoms had similar clinical characteristics and outcomes, when compared with patients with fever and respiratory symptoms. |
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| MeSH term(s) | Adult ; Aged ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19 Testing/methods ; Case-Control Studies ; China/epidemiology ; Female ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/virology ; Humans ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Severity of Illness Index ; Survival Analysis |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-08-18 |
| Publishing country | Australia |
| Document type | Journal Article |
| ZDB-ID | 632882-9 |
| ISSN | 1440-1746 ; 0815-9319 |
| ISSN (online) | 1440-1746 |
| ISSN | 0815-9319 |
| DOI | 10.1111/jgh.15199 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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