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  1. Article ; Online: Following-up allogeneic transplantation recipients during the COVID-19 pandemic.

    Lupo-Stanghellini, Maria Teresa / Messina, Carlo / Marktel, Sarah / Carrabba, Matteo G / Peccatori, Jacopo / Corti, Consuelo / Ciceri, Fabio

    The Lancet. Haematology

    2020  Volume 7, Issue 8, Page(s) e564–e565

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Disease Management ; Follow-Up Studies ; Graft vs Host Disease/diagnosis ; Graft vs Host Disease/etiology ; Graft vs Host Disease/therapy ; Humans ; Pandemics ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Stem Cell Transplantation/adverse effects ; Telemedicine/methods ; Transplantation, Homologous
    Keywords covid19
    Language English
    Publishing date 2020-05-22
    Publishing country England
    Document type Journal Article
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(20)30176-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Following-up allogeneic transplantation recipients during the COVID-19 pandemic

    Lupo-Stanghellini, Maria Teresa / Messina, Carlo / Marktel, Sarah / Carrabba, Matteo G / Peccatori, Jacopo / Corti, Consuelo / Ciceri, Fabio

    Lancet Haematol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32450053
    Database COVID19

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  3. Article ; Online: Following-up allogeneic transplantation recipients during the COVID-19 pandemic

    Lupo-Stanghellini, Maria Teresa / Messina, Carlo / Marktel, Sarah / Carrabba, Matteo G. / Peccatori, Jacopo / Corti, Consuelo / Ciceri, Fabio

    The Lancet Haematology

    2020  Volume 7, Issue 8, Page(s) e564–e565

    Keywords Hematology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2352-3026
    DOI 10.1016/s2352-3026(20)30176-9
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  4. Article ; Online: Antibody Response to SARS-CoV-2 Vaccination in Patients following Allogeneic Hematopoietic Cell Transplantation.

    Huang, Alice / Cicin-Sain, Caroline / Pasin, Chloe / Epp, Selina / Audigé, Annette / Müller, Nicolas J / Nilsson, Jakob / Bankova, Andriyana / Wolfensberger, Nathan / Vilinovszki, Oliver / Nair, Gayathri / Hockl, Philipp / Schanz, Urs / Kouyos, Roger D / Hasse, Barbara / Zinkernagel, Annelies S / Trkola, Alexandra / Manz, Markus G / Abela, Irene A /
    Müller, Antonia M S

    Transplantation and cellular therapy

    2022  Volume 28, Issue 4, Page(s) 214.e1–214.e11

    Abstract: ... in immunocompromised patients, including recipients of allogeneic hematopoietic cell transplantation (allo-HCT). Here we used ... to allo-HCT recipients and transplant physicians to guide treatment decisions regarding revaccination and ... social behavior during the SARS-CoV-2 pandemic. ...

    Abstract Vaccines against SARS-CoV-2 have been rapidly approved. Although pivotal studies were conducted in healthy volunteers, little information is available on the safety and efficacy of mRNA vaccines in immunocompromised patients, including recipients of allogeneic hematopoietic cell transplantation (allo-HCT). Here we used a novel assay to analyze patient- and transplantation-related factors and their influence on immune responses to SARS-CoV-2 vaccination over an extended period (up to 6 months) in a large and homogenous group of allo-HCT recipients at a single center in Switzerland. We examined longitudinal antibody responses to SARS-CoV-2 vaccination with BNT162b2 (BioNTech/Pfizer) and mRNA-1273 (Moderna) in 110 allo-HCT recipients and 86 healthy controls. Seroprofiling recording IgG, IgA, and IgM reactivity against SARS-CoV-2 antigens (receptor-binding domain, spike glycoprotein subunits S1 and S2, and nucleocapsid protein) was performed before vaccination, before the second dose, and at 1, 3, and 6 months after the second dose. Patients were stratified to 3 groups: 3 to 6 months post-allo-HCT, 6 to 12 months post-allo-HCT, and >12 months post-allo-HCT. Patients in the 3 to 6 months and 6 to 12 months post-allo-HCT groups developed significantly lower antibody titers after vaccination compared with patients in the >12 months post-allo-HCT group and healthy controls (P < .001). Within the cohort of allo-HCT recipients, patients age >65 years (P = .030), those receiving immunosuppression for prevention or treatment of graft-versus-host disease (GVHD) (P = .033), and patients with relapsed disease (P = .014) displayed low humoral immune responses to the vaccine. In contrast, the intensity of the conditioning regimen, underlying disease (myeloid/lymphoid/other), and presence of chronic GVHD had no impact on antibody levels. Antibody titers achieved the highest levels at 1 month after the second dose of the vaccine but waned substantially in all transplantation groups and healthy controls over time. This analysis of long-term vaccine antibody response is of critical importance to allo-HCT recipients and transplant physicians to guide treatment decisions regarding revaccination and social behavior during the SARS-CoV-2 pandemic.
    MeSH term(s) Aged ; Antibody Formation ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2022.01.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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