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  1. Article ; Online: Extracorporeal Membrane Oxygenation (ECMO) in Critically Ill Patients with Coronavirus Disease 2019 (COVID-19) Pneumonia and Acute Respiratory Distress Syndrome (ARDS).

    Ma, Xiaochun / Liang, Menglin / Ding, Min / Liu, Weiming / Ma, Huibo / Zhou, Xiaoming / Ren, Hongsheng

    Medical science monitor : international medical journal of experimental and clinical research

    2020  Volume 26, Page(s) e925364

    Abstract: ... among the critically ill with acute respiratory distress syndrome (ARDS) despite invasive mechanical ventilation, and is ... of extracorporeal membrane oxygenation (ECMO) for assisting respiration and circulation if necessary. This article reviews the pertinent ... WHO) estimated that approximately 14% of infections developed into severe disease, 5% were critically ill, and ...

    Abstract Traced back to December 2019, an unexpected outbreak of a highly contagious new coronavirus pneumonia (COVID-19) has rapidly swept around China and the globe. There have now been an estimated 2 580 000 infections and more than 170 000 fatal cases around the world. The World Health Organization (WHO) estimated that approximately 14% of infections developed into severe disease, 5% were critically ill, and the mortality rate of critically ill patients is reported to be over 50%. The shortage of specific anti-viral treatment and vaccines remains a huge challenge. In COVID-19, refractory hypoxemia is common among the critically ill with acute respiratory distress syndrome (ARDS) despite invasive mechanical ventilation, and is further complicated by respiratory and circulatory failure. This difficult situation calls for the use of extracorporeal membrane oxygenation (ECMO) for assisting respiration and circulation if necessary. This article reviews the pertinent clinical literature, technical guidance, and expert recommendations on use of ECMO in critically ill cases of COVID-19. Here, we present basic knowledge and opinions about COVID-19 and ECMO, review the evidence on ECMO use in Middle East Respiratory Syndrome (MERS) and H1N1 influenza, share the technical guidance and recommendations on use of ECMO in COVID-19, summarize the current use of ECMO against COVID-19 in China, and discuss the issues in use of ECMO in COVID-19.
    MeSH term(s) Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/therapy ; Critical Illness ; Extracorporeal Membrane Oxygenation ; Humans ; Pandemics ; Pneumonia/therapy ; Pneumonia, Viral/therapy ; Practice Guidelines as Topic ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1439041-3
    ISSN 1643-3750 ; 1234-1010
    ISSN (online) 1643-3750
    ISSN 1234-1010
    DOI 10.12659/MSM.925364
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Extracorporeal Membrane Oxygenation in Patients With COVID-19.

    Sreenivasan, Jayakumar / Ranka, Sagar / Lahan, Shubham / Abu-Haniyeh, Ahmed / Li, Heyi / Kaul, Risheek / Malik, Aaqib / Aronow, Wilbert S / Frishman, William H / Lansman, Steven

    Cardiology in review

    2021  Volume 30, Issue 3, Page(s) 129–133

    Abstract: ... from asymptomatic or mild cases to severe pneumonia with acute respiratory distress syndrome (ARDS) requiring ... the indications, challenges, complications, and clinical outcomes of ECMO utilization in critically ill patients ... with COVID-19-related ARDS. Most of these patients required venovenous ECMO. Although the risk of mortality ...

    Abstract Coronavirus disease 2019 (COVID-19) is characterized by a clinical spectrum of diseases ranging from asymptomatic or mild cases to severe pneumonia with acute respiratory distress syndrome (ARDS) requiring mechanical ventilation. Extracorporeal membrane oxygenation (ECMO) has been used as rescue therapy in appropriate patients with COVID-19 complicated by ARDS refractory to mechanical ventilation. In this study, we review the indications, challenges, complications, and clinical outcomes of ECMO utilization in critically ill patients with COVID-19-related ARDS. Most of these patients required venovenous ECMO. Although the risk of mortality and complications is very high among patients with COVID-19 requiring ECMO, it is similar to that of non-COVID-19 patients with ARDS requiring ECMO. ECMO is a resource-intensive therapy, with an inherent risk of complications, which makes its availability limited and its use challenging in the midst of a pandemic. Well-maintained data registries, with timely reporting of outcomes and evidence-based clinical guidelines, are necessary for the careful allocation of resources and for the development of standardized utilization protocols.
    MeSH term(s) COVID-19/complications ; COVID-19/therapy ; Extracorporeal Membrane Oxygenation/methods ; Humans ; Pandemics ; Respiratory Distress Syndrome/etiology ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2
    Language English
    Publishing date 2021-07-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1294965-6
    ISSN 1538-4683 ; 1061-5377
    ISSN (online) 1538-4683
    ISSN 1061-5377
    DOI 10.1097/CRD.0000000000000410
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Physical Therapy Management of a COVID-19 Patient on Extracorporeal Membrane Oxygenation

    Amany Raafat Mohamed / Ahmed Refaat Abd El Aziz Taha Malik / Ahmad Galal zaki Elbahrawi / Hisham Mohamed Hussein / Ahmed abdelmoniem ibrahim

    Journal of Clinical and Diagnostic Research, Vol 17, Iss 11, Pp 01-

    A Case Report

    2023  Volume 04

    Abstract: ... Respiratory Distress Syndrome (ARDS) young patient with COVID-19 on ECMO therapy, presenting with complaints ... from pneumonia to critically ill cases. Extracorporeal Membrane Oxygenation (ECMO) is a therapeutic procedure ... Coronavirus Disease-2019 (COVID-19) can be classified as a respiratory disease that ranges ...

    Abstract Coronavirus Disease-2019 (COVID-19) can be classified as a respiratory disease that ranges from pneumonia to critically ill cases. Extracorporeal Membrane Oxygenation (ECMO) is a therapeutic procedure that can treat severe cases of respiratory failure. Hereby, the authors present, a 28-year-old case of Acute Respiratory Distress Syndrome (ARDS) young patient with COVID-19 on ECMO therapy, presenting with complaints of weakness, decreased mobility and function, and depression. The patient has received physical therapy interventions during the hospitalisation period. Respiratory, mobility, activity level, and psychological assessments were done before and after treatment using blood gases, the Intensive Care Unit (ICU) Mobility Scale, the University of Michigan scale, and the Hamilton Anxiety and Depression Rating Scale, respectively. There was an improvement in respiratory function, mobility (scores increased from 0 to 1), activity level (scores increased from 0 to 3), and psychological well-being (depression scores decreased from 18 to 15, and anxiety scores decreased from 20 to 14) after physical therapy. The treatment resulted in better recovery and prevented the worsening of the COVID-19 disease scenario.
    Keywords coronavirus disease-2019 ; physical therapy modalities ; venovenous extracorporeal membrane oxygenation ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: The Saudi Critical Care Society extracorporeal life support chapter guidance on utilization of veno-venous extracorporeal membrane oxygenation in adults with acute respiratory distress syndrome and special considerations in the era of coronavirus disease 2019.

    Mufti, Hani N / Rabie, Ahmed A / Elhazmi, Alyaa M / Bahaudden, Husam A / Rajab, Mostafa A / Al Enezi, Ismael S / Assiri, Ayed Y / Maghrabi, Khalid A / Al Bshabshe, Ali A / Abudayah, Abdullah M / Tash, Adel A / Al-Omari, Awad A / Azzam, Mohamed H

    Saudi medical journal

    2021  Volume 42, Issue 6, Page(s) 589–611

    Abstract: ... been applied as a rescue treatment for patients with severe adult respiratory distress syndrome (ARDS ... a guidance for the use of ECMO as a last resort for patients with severe ARDS, especially with COVID-19 based ... the cause of this severe mysterious illness that was named severe acute respiratory syndrome coronavirus 2 ...

    Abstract Extracorporeal membrane oxygenation (ECMO) is considered as a supportive treatment that provides circulatory and ventilatory support and can be thought off as a bridge to organ recovery. Since 2009, it has been applied as a rescue treatment for patients with severe adult respiratory distress syndrome (ARDS) mainly due to viral causes. In December 2019, several patients presented with a constellation of symptoms of viral pneumonia in China. A new strain of the corona virus family, called COVID-19, has been discovered to be the cause of this severe mysterious illness that was named severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). This new virus continued to spread across the globe leading to the World Health Organization announcing it as a pandemic in the early 2020. By the end of March 2021, the number of COVID-19 cases worldwide exceeded 126 million cases. In Saudi Arabia, the first confirmed case of COVID-19 was reported in the 2nd March 2020. By the end of March 2021, the total number of confirmed COVID-19 cases in Saudi Arabia is just above 360,000. In anticipation of the need of ECMO for the treatment of patients with SARS‑CoV‑2 based on the previous Middle East respiratory syndrome coronavirus pandemic experience, the Saudi Extra-Corporeal Life Support (ECLS) chapter that is under the umbrella of the Saudi Critical Care Society (SCCS) convened a working group of ECMO experts. The mission of this group was to formulate a guidance for the use of ECMO as a last resort for patients with severe ARDS, especially with COVID-19 based on available evidence. The ECLS-SCCS chapter wanted to generate a document that can be used to simple guide, with a focus on safety, to provide ECMO service for patients with severe ARDS with a special focus on SARS‑CoV‑2.
    MeSH term(s) Adult ; Animals ; COVID-19/therapy ; COVID-19/virology ; Extracorporeal Membrane Oxygenation/methods ; Humans ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2/isolation & purification ; Saudi Arabia
    Language English
    Publishing date 2021-06-02
    Publishing country Saudi Arabia
    Document type Journal Article ; Practice Guideline
    ZDB-ID 392302-2
    ISSN 1658-3175 ; 0379-5284
    ISSN (online) 1658-3175
    ISSN 0379-5284
    DOI 10.15537/smj.2021.42.6.20200520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2330: Show issues Location:
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  5. Article ; Online: Extracorporeal membrane oxygenation for critically ill patients with coronavirus-associated disease 2019: an updated perspective of the European experience.

    Marullo, Antonino G / Cavarretta, Elena / Biondi Zoccai, Giuseppe / Mancone, Massimo / Peruzzi, Mariangela / Piscioneri, Fernando / Sartini, Patrizio / Versaci, Francesco / Morelli, Andrea / Miraldi, Fabio / Frati, Giacomo

    Minerva cardioangiologica

    2020  Volume 68, Issue 5, Page(s) 368–372

    Abstract: ... coronavirus-associated disease 2019 (COVID-2019), may occasionally lead to acute respiratory distress syndrome ... if any, are currently available on the role of ECMO in critically ill patients with COVID-19. We aimed ... 004).: Conclusions: ECMO may play an important role in critically ill patients with COVID-19 ...

    Abstract Background: Infection due to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), i.e. coronavirus-associated disease 2019 (COVID-2019), may occasionally lead to acute respiratory distress syndrome (ARDS), requiring in the most severe cases extracorporeal membrane oxygenation (ECMO). Yet, limited data, if any, are currently available on the role of ECMO in critically ill patients with COVID-19. We aimed at providing a snapshot analysis of ECMO for COVID-19 in Europe.
    Methods: Freely available data on ECMO in COVID-19 patients reported by the European Extracorporeal Life Support Organization (EuroELSO) were extracted and analyzed after conversion into long format. The primary outcome was the incidence of death during ECMO. Bootstrapping and logistic regression were used for inferential estimates.
    Results: Details from a total of 333 patients treated in 90 institutions spanning 17 countries were obtained, with 22% women and mean age of 52 years. Death rate was 17.1% (95% confidence interval: 13.1% to 21.1%), even if significant between-center differences were found, with some institutions reporting 100% case fatality. Exploratory inferential analysis showed no nominally statistically significant association between death and gender (P=0.788), but a significant association was found with age, mainly due to increased case fatality in subjects >60 years (odds ratio: 4.80 [95% confidence interval 1.64 to 14.04], P=0.004).
    Conclusions: ECMO may play an important role in critically ill patients with COVID-19 refractory to less invasive treatments. The increased risk of early death in older patients may be used to prioritize ECMO indication in resource-conscious settings, if confirmed externally.
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Coronavirus Infections/therapy ; Critical Illness/therapy ; Europe/epidemiology ; Extracorporeal Membrane Oxygenation/methods ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Respiratory Distress Syndrome/complications ; Respiratory Distress Syndrome/therapy ; Sex Factors
    Keywords covid19
    Language English
    Publishing date 2020-04-27
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123583-7
    ISSN 1827-1618 ; 0026-4725
    ISSN (online) 1827-1618
    ISSN 0026-4725
    DOI 10.23736/S0026-4725.20.05328-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Extracorporeal Membrane Oxygenation in the Treatment of Severe Pulmonary and Cardiac Compromise in Coronavirus Disease 2019: Experience with 32 Patients.

    Jacobs, Jeffrey P / Stammers, Alfred H / St Louis, James / Hayanga, J W Awori / Firstenberg, Michael S / Mongero, Linda B / Tesdahl, Eric A / Rajagopal, Keshava / Cheema, Faisal H / Coley, Tom / Badhwar, Vinay / Sestokas, Anthony K / Slepian, Marvin J

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2020  Volume 66, Issue 7, Page(s) 722–730

    Abstract: ... in patients with COVID-19 and acute respiratory distress syndrome (ARDS). These initial data may provide ... a useful role in salvaging select critically ill patients with COVID-19. Additional patient experience and ... patients with COVID-19 who develop acute respiratory and cardiac compromise refractory to conventional ...

    Abstract As coronavirus disease 2019 (COVID-19) cases surge worldwide, an urgent need exists to enhance our understanding of the role of extracorporeal membrane oxygenation (ECMO) in the management of severely ill patients with COVID-19 who develop acute respiratory and cardiac compromise refractory to conventional therapy. The purpose of this manuscript is to review our initial clinical experience in 32 patients with confirmed COVID-19 treated with ECMO. A multi-institutional registry and database was created and utilized to assess all patients who were supported with ECMO provided by SpecialtyCare. Data captured included patient characteristics, pre-COVID-19 risk factors and comorbidities, confirmation of COVID-19 diagnosis, features of ECMO support, specific medications utilized to treat COVID-19, and short-term outcomes through hospital discharge. This analysis includes all of our patients with COVID-19 supported with ECMO, with an analytic window starting March 17, 2020, when our first COVID-19 patient was placed on ECMO, and ending April 9, 2020. During the 24 days of this study, 32 consecutive patients with COVID-19 were placed on ECMO at nine different hospitals. As of the time of analysis, 17 remain on ECMO, 10 died before or shortly after decannulation, and five are alive and extubated after removal from ECMO, with one of these five discharged from the hospital. Adjunctive medication in the surviving patients while on ECMO was as follows: four of five survivors received intravenous steroids, three of five survivors received antiviral medications (Remdesivir), two of five survivors were treated with anti-interleukin-6-receptor monoclonal antibodies (Tocilizumab or Sarilumab), and one of five survivors received hydroxychloroquine. Analysis of these 32 COVID-19 patients with severe pulmonary compromise supported with ECMO suggests that ECMO may play a useful role in salvaging select critically ill patients with COVID-19. Additional patient experience and associated clinical and laboratory data must be obtained to further define the optimal role of ECMO in patients with COVID-19 and acute respiratory distress syndrome (ARDS). These initial data may provide useful information to help define the best strategies to care for these challenging patients and may also provide a framework for much-needed future research about the use of ECMO to treat patients with COVID-19.
    MeSH term(s) Adult ; Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Extracorporeal Membrane Oxygenation ; Female ; Heart Diseases/therapy ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Receptors, Interleukin-6/antagonists & inhibitors ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2
    Chemical Substances Receptors, Interleukin-6
    Keywords covid19
    Language English
    Publishing date 2020-04-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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