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  1. Article ; Online: Electrolyte Disturbances in SARS-CoV-2 Infection.

    Mabillard, Holly / Sayer, John A

    F1000Research

    2020  Volume 9, Page(s) 587

    Abstract: ... on hypokalaemia and SARS-CoV-2 infection, the potential pathophysiological mechanisms based on early clinical and ... The global pandemic secondary to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ... secondary to SARS-CoV-2 was common in a reported Chinese cohort. Here we review the emerging evidence ...

    Abstract The global pandemic secondary to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is leading to unprecedented global morbidity and mortality. With a bewildering array of complications, renal involvement in various forms is common, including serum electrolyte derangements. Hypokalaemia secondary to SARS-CoV-2 was common in a reported Chinese cohort. Here we review the emerging evidence on hypokalaemia and SARS-CoV-2 infection, the potential pathophysiological mechanisms based on early clinical and histopathological data and important clinical implications. Mechanisms of hypokalaemia are multifactorial and so the electrolyte disturbance can be difficult to avoid. We provide further support to the theory of renin-angiotensin-aldosterone (RAS) activation, discuss the strengths and weaknesses of implicating RAS involvement and highlight the importance of calculating the transtubular potassium gradient to identify those at risk of hypokalaemia and its complications.
    MeSH term(s) Humans ; Aldosterone ; Betacoronavirus ; Coronavirus Infections/complications ; COVID-19 ; Electrolytes ; Hypokalemia/virology ; Pandemics ; Pneumonia, Viral/complications ; Potassium ; Renin-Angiotensin System ; SARS-CoV-2
    Chemical Substances Aldosterone (4964P6T9RB) ; Electrolytes ; Potassium (RWP5GA015D)
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.24441.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Electrolyte Disturbances in SARS-CoV-2 Infection

    Mabillard, Holly / Sayer, John A

    F1000Res

    Abstract: ... on hypokalaemia and SARS-CoV-2 infection, the potential pathophysiological mechanisms based on early clinical and ... The global pandemic secondary to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ... secondary to SARS-CoV-2 was common in a reported Chinese cohort. Here we review the emerging evidence ...

    Abstract The global pandemic secondary to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is leading to unprecedented global morbidity and mortality. With a bewildering array of complications, renal involvement in various forms is common, including serum electrolyte derangements. Hypokalaemia secondary to SARS-CoV-2 was common in a reported Chinese cohort. Here we review the emerging evidence on hypokalaemia and SARS-CoV-2 infection, the potential pathophysiological mechanisms based on early clinical and histopathological data and important clinical implications. Mechanisms of hypokalaemia are multifactorial and so the electrolyte disturbance can be difficult to avoid. We provide further support to the theory of renin-angiotensin-aldosterone (RAS) activation, discuss the strengths and weaknesses of implicating RAS involvement and highlight the importance of calculating the transtubular potassium gradient to identify those at risk of hypokalaemia and its complications.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #902995
    Database COVID19

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  3. Article ; Online: Electrolyte Disturbances in SARS-CoV-2 Infection [version 2; peer review

    Holly Mabillard / John A. Sayer

    F1000Research, Vol

    2 approved]

    2020  Volume 9

    Abstract: ... on hypokalaemia and SARS-CoV-2 infection, the potential pathophysiological mechanisms based on early clinical and ... The global pandemic secondary to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ... secondary to SARS-CoV-2 was common in a reported Chinese cohort. Here we review the emerging evidence ...

    Abstract The global pandemic secondary to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is leading to unprecedented global morbidity and mortality. With a bewildering array of complications, renal involvement in various forms is common, including serum electrolyte derangements. Hypokalaemia secondary to SARS-CoV-2 was common in a reported Chinese cohort. Here we review the emerging evidence on hypokalaemia and SARS-CoV-2 infection, the potential pathophysiological mechanisms based on early clinical and histopathological data and important clinical implications. Mechanisms of hypokalaemia are multifactorial and so the electrolyte disturbance can be difficult to avoid. We provide further support to the theory of renin-angiotensin-aldosterone (RAS) activation, discuss the strengths and weaknesses of implicating RAS involvement and highlight the importance of calculating the transtubular potassium gradient to identify those at risk of hypokalaemia and its complications.
    Keywords Medicine ; R ; Science ; Q ; covid19
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Electrolyte disturbances in patients hospitalized for COVID-19 infection: An observational study.

    Cancarevic, Ivan / Nassar, Mahmoud / Foster, Allison / Umar, Zaryab / Parikh, Avish / Ahammed, Md Ripon / Shaban, Lilia / Abosheaishaa, Hazem / Mergen, Damla / Amin, Toka / Ozkan, Bike Ilayda / Sánchez Ruiz, Angélica M / Hosna, Asma / Ul Rasool, Muhammad Haseeb / Ahmed, Nazaakat / Ayotunde, Fatima / Ashfaq, Salman / Lopez, Ricardo / Rizzo, Vincent

    Medicine

    2024  Volume 103, Issue 20, Page(s) e37749

    Abstract: ... of these electrolytes were 138.3 ± 5.06, 4.18 ± 0.59, 3.578 ± 0.59, and 2.11 ± 0.64, respectively. Patients suffering ... electrolyte abnormalities, which may not be the case for bacterial causes of pneumonia. This study aimed ... to assess the differences in electrolyte levels between patients suffering from COVID-19 and ...

    Abstract There are multiple mechanisms by which The Coronavirus-19 (COVID-19) infection can cause electrolyte abnormalities, which may not be the case for bacterial causes of pneumonia. This study aimed to assess the differences in electrolyte levels between patients suffering from COVID-19 and bacterial pneumonia. This is an original, retrospective study. Two cohorts of hospitalized patients were included, 1 suffering from COVID-19 and the other from bacterial pneumonia. Their day 1 and day 3 levels of sodium, potassium, magnesium, and phosphorus, as well as their outcomes, were extracted from the charts. Statistical analysis was subsequently performed. Mean admission levels of sodium, potassium, phosphorus, and magnesium were 135.64 ± 6.13, 4.38 ± 0.69, 3.53 ± 0.69, and 2.03 ± 0.51, respectively. The mean day 3 levels of these electrolytes were 138.3 ± 5.06, 4.18 ± 0.59, 3.578 ± 0.59, and 2.11 ± 0.64, respectively. Patients suffering from bacterial pneumonia were significantly older (N = 219, mean = 64.88 ± 15.99) than patients with COVID-19 pneumonia (N = 240, mean = 57.63 ± 17.87). Bacterial pneumonia group had significantly higher serum potassium (N = 211, mean = 4.51 ± 0.76), and magnesium (N = 115, mean = 2.12 ± 0.60) levels compared to COVID-19 group (N = 227, mean = 4.254 ± 0.60 for potassium and N = 118, mean = 1.933 ± 0.38 for magnesium). Only magnesium was significantly higher among day 3 electrolytes in the bacterial pneumonia group. No significant association between electrolyte levels and outcomes was seen. We found that COVID-19 patients had lower potassium and magnesium levels on admission, possibly due to the effect of COVID-19 on the renin-angiotensin-aldosterone system as well as patient characteristics and management. We did not find enough evidence to recommend using electrolyte levels as a determinator of prognosis, but more research is needed.
    MeSH term(s) Humans ; COVID-19/complications ; COVID-19/blood ; Male ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Hospitalization/statistics & numerical data ; Water-Electrolyte Imbalance/epidemiology ; Water-Electrolyte Imbalance/blood ; Pneumonia, Bacterial/blood ; Pneumonia, Bacterial/complications ; Pneumonia, Bacterial/epidemiology ; Potassium/blood ; Magnesium/blood ; SARS-CoV-2 ; Electrolytes/blood ; Sodium/blood ; Phosphorus/blood
    Language English
    Publishing date 2024-05-17
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000037749
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  5. Article ; Online: Prior fluid and electrolyte imbalance is associated with COVID-19 mortality

    Satu Nahkuri / Tim Becker / Vitalia Schueller / Steffen Massberg / Anna Bauer-Mehren

    Communications Medicine, Vol 1, Iss 1, Pp 1-

    2021  Volume 10

    Abstract: ... a disturbance of electrolyte or fluid levels in the year before they contracted SARS-CoV-2 were more likely ... balancing of the hydration and electrolyte status during and even before a SARS-CoV-2 infection may be ...

    Abstract Plain language summary The clinical course of patients with COVID-19 is highly variable, with some patients barely affected and others dying. We wanted to better understand why this is the case and identify markers of COVID-19-associated mortality. To this end, we looked into the entire available medical history of more than 100,000 COVID-19 patients from the United States. We found that patients who had experienced a disturbance of electrolyte or fluid levels in the year before they contracted SARS-CoV-2 were more likely to die than patients without such a history. This observation suggests that careful monitoring and balancing of the hydration and electrolyte status during and even before a SARS-CoV-2 infection may be beneficial and possibly reduce the risk of death with COVID-19.
    Keywords Medicine ; R
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Hydroelectrolytic Disorder in COVID-19 patients: Evidence Supporting the Involvement of Subfornical Organ and Paraventricular Nucleus of the Hypothalamus.

    de Melo, Igor Santana / Sabino-Silva, Robinson / Cunha, Thúlio Marquez / Goulart, Luiz Ricardo / Reis, Wagner Luis / Jardim, Ana Carolina Gomes / Shetty, Ashok K / de Castro, Olagide Wagner

    Neuroscience and biobehavioral reviews

    2021  Volume 124, Page(s) 216–223

    Abstract: ... by which SARS-CoV-2 infection of the SFO-PVN-SON pathway leads to hydroelectrolytic disorder in COVID-19 ... PVN-SON circuitry in modulating hydroelectrolyte balance, SARS-CoV-2 infection in these regions ... supraoptic nucleus (SON), leading to hydroelectrolytic disorder. SARS-CoV-2 can readily enter SFO-PVN-SON neurons ...

    Abstract Multiple neurological problems have been reported in coronavirus disease-2019 (COVID-19) patients because severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) likely spreads to the central nervous system (CNS) via olfactory nerves or through the subarachnoid space along olfactory nerves into the brain's cerebrospinal fluid and then into the brain's interstitial space. We hypothesize that SARS-CoV-2 enters the subfornical organ (SFO) through the above routes and the circulating blood since circumventricular organs (CVOs) such as the SFO lack the blood-brain barrier, and infection of the SFO causes dysfunction of the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON), leading to hydroelectrolytic disorder. SARS-CoV-2 can readily enter SFO-PVN-SON neurons because these neurons express angiotensin-converting enzyme-2 receptors and proteolytic viral activators, which likely leads to neurodegeneration or neuroinflammation in these regions. Considering the pivotal role of SFO-PVN-SON circuitry in modulating hydroelectrolyte balance, SARS-CoV-2 infection in these regions could disrupt the neuroendocrine control of hydromineral homeostasis. This review proposes mechanisms by which SARS-CoV-2 infection of the SFO-PVN-SON pathway leads to hydroelectrolytic disorder in COVID-19 patients.
    MeSH term(s) Animals ; COVID-19/complications ; COVID-19/pathology ; Humans ; Paraventricular Hypothalamic Nucleus/pathology ; Paraventricular Hypothalamic Nucleus/virology ; Power Plants ; Subfornical Organ/pathology ; Subfornical Organ/virology ; Water-Electrolyte Imbalance/etiology ; Water-Electrolyte Imbalance/virology
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 282464-4
    ISSN 1873-7528 ; 0149-7634
    ISSN (online) 1873-7528
    ISSN 0149-7634
    DOI 10.1016/j.neubiorev.2021.02.008
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