Article ; Online: How to make a heart valve: from embryonic development to bioengineering of living valve substitutes.
Cold Spring Harbor perspectives in medicine
2014 Volume 4, Issue 11, Page(s) a013912
Abstract: ... substitutes have the potential for remodeling, regeneration, and growth of native structures. Valve ... valve substitutes endowed with native form and function. ... Cardiac valve disease is a significant cause of ill health and death worldwide, and valve ...
| Abstract | Cardiac valve disease is a significant cause of ill health and death worldwide, and valve replacement remains one of the most common cardiac interventions in high-income economies. Despite major advances in surgical treatment, long-term therapy remains inadequate because none of the current valve substitutes have the potential for remodeling, regeneration, and growth of native structures. Valve development is coordinated by a complex interplay of signaling pathways and environmental cues that cause disease when perturbed. Cardiac valves develop from endocardial cushions that become populated by valve precursor mesenchyme formed by an epithelial-mesenchymal transition (EMT). The mesenchymal precursors, subsequently, undergo directed growth, characterized by cellular compartmentalization and layering of a structured extracellular matrix (ECM). Knowledge gained from research into the development of cardiac valves is driving exploration into valve biomechanics and tissue engineering directed at creating novel valve substitutes endowed with native form and function. |
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| MeSH term(s) | Animals ; Extracellular Matrix/physiology ; Heart Valve Prosthesis ; Heart Valves/anatomy & histology ; Heart Valves/cytology ; Heart Valves/embryology ; Humans ; Morphogenesis/physiology ; Tissue Engineering ; Tissue Scaffolds |
| Language | English |
| Publishing date | 2014-11-03 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ISSN | 2157-1422 |
| ISSN (online) | 2157-1422 |
| DOI | 10.1101/cshperspect.a013912 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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