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  1. Article ; Online: CHILDHOOD SYSTEMIC LUPUS ERYTHEMATOSUS AND COVID-19.

    Mackie, Fiona E / Hahn, Deirdre / Chaitow, Jeffrey / Tchang, Andrew / Krischock, Leah

    Journal of paediatrics and child health

    2021  Volume 57, Issue 5, Page(s) 764

    MeSH term(s) COVID-19 ; Case-Control Studies ; Child ; Humans ; Lupus Erythematosus, Systemic ; SARS-CoV-2
    Language English
    Publishing date 2021-03-22
    Publishing country Australia
    Document type Letter
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.15451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Asymptomatic SARS-CoV-2 seropositivity: patients with childhood-onset rheumatic diseases versus healthy children.

    Haslak, Fatih / Ozbey, Dogukan / Yildiz, Mehmet / Adrovic, Amra / Sahin, Sezgin / Koker, Oya / Aliyeva, Ayten / Guliyeva, Vafa / Yalcin, Gamze / Inanli, Gulmelek / Kocazeybek, Bekir S / Kasapcopur, Ozgur / Barut, Kenan

    Clinical rheumatology

    2022  Volume 41, Issue 5, Page(s) 1523–1533

    Abstract: ... juvenile idiopathic arthritis (JIA), and juvenile systemic lupus erythematosus (jSLE) and healthy children as healthy control ... We revealed that patients with childhood-onset rheumatic diseases, even if they receive immunosuppressive ... the asymptomatic SARS-CoV-2 seropositivity rates between healthy children and the patients with childhood-onset ...

    Abstract Objective: We aimed to find out the asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence among pediatric patients with rheumatic diseases and healthy children and to compare them with each other.
    Methods: Patients with familial Mediterranean fever (FMF), juvenile idiopathic arthritis (JIA), and juvenile systemic lupus erythematosus (jSLE) and healthy children as healthy control (HC) group who remained asymptomatic during the pandemic are examined by ELISA immunoglobulin (Ig) A and IgG tests in this cross-sectional study.
    Results: Overall, 149 subjects (90 females) were included in the study. While IgA was positive in 15 subjects (10%) (HC: 8, jSLE: 3, FMF: 2, JIA: 2; p = 0.196), IgG was positive in 14 subjects (9.4%) (HC: 7, JIA: 5, FMF: 1, jSLE: 1; p = 0.156). Nineteen subjects (12.75%) were IgA or IgG positive (HC: 8, JIA: 5, jSLE: 3, FMF: 3; p = 0.644). Although not significant, seropositivity was more often in HC group. Both IgA and IgG positivity were not found to be related to age, sex, underlying rheumatic diseases, and received treatments of the patients.
    Conclusion: We revealed that patients with childhood-onset rheumatic diseases, even if they receive immunosuppressive medication such as biologic or conventional disease-modifying anti-rheumatic drugs, might have an asymptomatic SARS-CoV-2 infection, similarly to their healthy peers. Key points • Although it has been already known that children are most likely to have asymptomatic SARS-CoV-2 infection, there is a lack of data on the disease course of children with rheumatic disease. • There was no significant difference regarding the asymptomatic SARS-CoV-2 seropositivity rates between healthy children and the patients with childhood-onset rheumatic diseases. • Patients with childhood-onset rheumatic diseases, even if they receive immunosuppressive medication, might have asymptomatic SARS-CoV-2 infection, similarly to their healthy peers.
    MeSH term(s) Arthritis, Juvenile/drug therapy ; COVID-19 ; Child ; Cross-Sectional Studies ; Female ; Humans ; Immunoglobulin A ; Immunoglobulin G ; Lupus Erythematosus, Systemic ; Male ; Rheumatic Diseases/epidemiology ; SARS-CoV-2 ; Seroepidemiologic Studies
    Chemical Substances Immunoglobulin A ; Immunoglobulin G
    Language English
    Publishing date 2022-01-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-022-06067-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1740: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: A multi-site pilot randomized clinical trial of the Treatment and Education Approach for Childhood-onset Lupus (TEACH) program: study design and COVID-19 adaptations.

    Cunningham, Natoshia R / Miller, Alaina / Ely, Samantha L / Reid, Mallet R / Danguecan, Ashley / Mossad, Sarah I / Pereira, Luana Flores / Abulaban, Khalid / Kessler, Elizabeth / Rosenwasser, Natalie / Nanda, Kabita / Rubinstein, Tamar / Reeves, Mathew / Kohut, Sara Ahola / Stinson, Jennifer / Tal, Tala El / Levy, Deborah M / Hiraki, Linda / Smitherman, Emily A /
    Knight, Andrea M

    Pediatric rheumatology online journal

    2023  Volume 21, Issue 1, Page(s) 61

    Abstract: Background: Childhood-onset Systemic Lupus Erythematosus (cSLE) is an autoimmune disease ... the feasibility and effect of TEACH for youth with cSLE. Adjustments to the study protocol following the COVID-19 ... later. Protocol adjustments were also made due to the COVID-19 pandemic, in collaboration ...

    Abstract Background: Childhood-onset Systemic Lupus Erythematosus (cSLE) is an autoimmune disease associated with fatigue, mood symptoms, and pain. Fortunately, these symptoms are potentially modifiable with psychological intervention such as cognitive-behavioral therapy (CBT). The Treatment and Education Approach for Childhood-onset Lupus (TEACH) program is a CBT intervention developed to target these symptoms for adolescents and young adults with cSLE. This pilot randomized controlled trial (RCT) aims to determine the feasibility and effect of TEACH for youth with cSLE. Adjustments to the study protocol following the COVID-19 pandemic are also described.
    Methods: This two-arm multisite RCT will explore the feasibility (primary outcome) and effect (secondary outcome) of a remotely delivered TEACH protocol. Participants will be randomized to a six-week remotely delivered TEACH program plus medical treatment as usual (TAU) or TAU alone. We will include patients ages 12-22 years presenting to rheumatology clinics from six sites. Validated measures of fatigue, depressive symptoms, and pain will be obtained at baseline and approximately eight and 20 weeks later. Protocol adjustments were also made due to the COVID-19 pandemic, in collaboration with the investigative team, which included patients and caregivers.
    Conclusions: Findings from this multi-site RCT aim to document the feasibility of TEACH and provide an estimate of effect of a remotely delivered TEACH protocol on fatigue, depression, and pain symptoms in youth with cSLE as compared to standard medical treatment alone. This findings may positively impact clinical care for patients with cSLE.
    Clinical trials: gov registration: NCT04335643.
    MeSH term(s) Adolescent ; Child ; Humans ; Young Adult ; COVID-19 ; Fatigue ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/therapy ; Lupus Erythematosus, Systemic/psychology ; Pain ; Pilot Projects
    Language English
    Publishing date 2023-06-23
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 2279468-2
    ISSN 1546-0096 ; 1546-0096
    ISSN (online) 1546-0096
    ISSN 1546-0096
    DOI 10.1186/s12969-023-00835-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Childhood-onset systemic lupus erythematosus, probably triggered by severe acute respiratory syndrome coronavirus 2 infection, presenting with autoimmune haemolytic anaemia

    Abdul Rauf / Shinto Francis Thekkudan / Neena Mampilly / Ajay Vijayan

    Current Medicine Research and Practice, Vol 12, Iss 5, Pp 235-

    2022  Volume 237

    Abstract: Systemic lupus erythematosus (SLE) is a multisystemic and chronic autoimmune disease with varying ... positive autoimmune haemolytic anaemia, 3 weeks after testing positive for COVID-19. COVID IgG antibody ...

    Abstract Systemic lupus erythematosus (SLE) is a multisystemic and chronic autoimmune disease with varying clinical manifestations. The role of various infectious agents in triggering the disease onset in genetically predisposed patients has been implicated in the pathogenesis of SLE. The severe acute respiratory syndrome coronavirus 2 has been reported to trigger various autoimmune diseases including SLE in few adults. Herein, we report the case of a previously well 12-year-old girl who presented with warm antibody Coombs-positive autoimmune haemolytic anaemia, 3 weeks after testing positive for COVID-19. COVID IgG antibody test was positive. During the hospital stay, she developed multisystem involvement in the form of neurological manifestations and arthritis. She was managed with steroids, intravenous (IV) immunoglobulins and supportive measures. Her anti-nuclear antibody and anti-dsDNA antibodies were positive and complement levels were low, confirming a diagnosis of SLE. Her clinical condition improved rapidly and remained neurologically normal, and serial haemoglobin showed an improving trend. IV steroids were changed to oral form, and hydroxychloroquine was also added. She remained well on 3-week follow-up.
    Keywords autoimmune haemolytic anaemia ; children ; covid-19 ; severe acute respiratory syndrome coronavirus 2 ; systemic lupus erythematosus ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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