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  1. Article ; Online: Impact of cardiovascular disease on clinical outcomes in hospitalized patients with Covid-19: a systematic review and meta-analysis.

    Maddaloni, Ernesto / D'Onofrio, Luca / Siena, Antonio / Luordi, Cecilia / Mignogna, Carmen / Amendolara, Rocco / Cavallari, Ilaria / Grigioni, Francesco / Buzzetti, Raffaella

    Internal and emergency medicine

    2021  Volume 16, Issue 7, Page(s) 1975–1985

    Abstract: ... hospitalized for Covid-19, cardiovascular disease confers higher risk of death, which was highly mitigated ... of prevention strategies. To clarify the association of cardiovascular disease with Covid-19 outcomes ... Contrasting data have been published about the impact of cardiovascular disease on Covid-19 ...

    Abstract Contrasting data have been published about the impact of cardiovascular disease on Covid-19. A comprehensive synthesis and pooled analysis of the available evidence is needed to guide prioritization of prevention strategies. To clarify the association of cardiovascular disease with Covid-19 outcomes, we searched PubMed up to 26 October 2020, for studies reporting the prevalence of cardiovascular disease among inpatients with Covid-19 in relation to their outcomes. Pooled odds-ratios (OR) for death, for mechanical ventilation or admission in an intensive care unit (ICU) and for composite outcomes were calculated using random effect models overall and in the subgroup of people with comorbid diabetes. Thirty-three studies enrolling 52,857 inpatients were included. Cardiovascular disease was associated with a higher risk of death both overall (OR 2.58, 95% confidence intervals, CI 2.12-3.14, p < 0.001, number of studies 24) and in the subgroup of people with diabetes (OR 2.91, 95% CI 2.13-3.97, p < 0.001, number of studies 4), but not with higher risk of ICU admission or mechanical ventilation (OR 1.35, 95% CI 0.73-2.50, p = 0.34, number of studies 4). Four out of five studies reporting OR adjusted for confounders failed to show independent association of cardiovascular disease with Covid-19 deaths. Accordingly, the adjusted-OR for Covid-19 death in people with cardiovascular disease dropped to 1.31 (95% CI 1.01-1.70, p = 0.041). Among patients hospitalized for Covid-19, cardiovascular disease confers higher risk of death, which was highly mitigated when adjusting the association for confounders.
    MeSH term(s) COVID-19/complications ; COVID-19/mortality ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/mortality ; Comorbidity ; Critical Care/statistics & numerical data ; Humans ; Intensive Care Units ; Respiration, Artificial/mortality
    Language English
    Publishing date 2021-07-17
    Publishing country Italy
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02804-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Impact of telehealth interventions added to peritoneal dialysis-care: a systematic review.

    Biebuyck, Geertje K M / Neradova, Aegida / de Fijter, Carola W H / Jakulj, Lily

    BMC nephrology

    2022  Volume 23, Issue 1, Page(s) 292

    Abstract: ... on the impact of telehealth interventions added to PD-care on quality of life (QoL), clinical outcomes and cost ... with peritoneal dialysis (PD). Moreover, it might improve clinical and economic outcomes. The demand for telehealth ... mortality, cardiovascular disease and transfer to hemodialysis (HD); iii. Cost-effectiveness. Studies ...

    Abstract Background: Telehealth could potentially increase independency and autonomy of patients treated with peritoneal dialysis (PD). Moreover, it might improve clinical and economic outcomes. The demand for telehealth modalities accelerated significantly in the recent COVID-19 pandemic. We evaluated current literature on the impact of telehealth interventions added to PD-care on quality of life (QoL), clinical outcomes and cost-effectiveness.
    Methods: An electronic search was performed in Embase, PubMed and the Cochrane Library in order to find studies investigating associations between telehealth interventions and: i. QoL, including patient satisfaction; ii. Standardized Outcomes in Nephrology (SONG)-PD clinical outcomes: PD-related infections, mortality, cardiovascular disease and transfer to hemodialysis (HD); iii. Cost-effectiveness. Studies investigating hospitalizations and healthcare resource utilization were also included as secondary outcomes. Due to the heterogeneity of studies, a meta-analysis could not be performed.
    Results: Sixteen reports (N = 10,373) were included. Studies varied in terms of: sample size; design; risk of bias, telehealth-intervention and duration; follow-up time; outcomes and assessment tools. Remote patient monitoring (RPM) was the most frequently studied intervention (11 reports; N = 4982). Telehealth interventions added to PD-care, and RPM in particular, might reduce transfer to HD, hospitalization rate and length, as well as the number of in-person visits. It may also improve patient satisfaction.
    Conclusion: There is a need for adequately powered prospective studies to determine which telehealth-modalities might confer clinical and economic benefit to the PD-community.
    MeSH term(s) COVID-19/epidemiology ; Humans ; Pandemics ; Peritoneal Dialysis ; Prospective Studies ; Quality of Life ; Telemedicine
    Language English
    Publishing date 2022-08-23
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-022-02869-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prevalence and impact of cardiac injury on COVID-19: A systematic review and meta-analysis.

    Fu, Linghua / Liu, Xiao / Su, Yuhao / Ma, Jianyong / Hong, Kui

    Clinical cardiology

    2020  Volume 44, Issue 2, Page(s) 276–283

    Abstract: ... injury and its impact on the outcomes in patients with COVID-19.: Hypothesis: Cardiac injury is common ... of cardiac injury on COVID-19. Cardiac injury is common in hospitalized patients and advanced age and severe ... 28% among hospitalized patients with COVID-19 or severe COVID-19 patients, respectively ...

    Abstract Background: The exact prevalence and impact of cardiac injury in hospitalized patients with coronavirus disease 2019 (COVID-19) is still controversial. Hence, we aim to investigate prevalence of cardiac injury and its impact on the outcomes in patients with COVID-19.
    Hypothesis: Cardiac injury is common and associated with higher risk of death.
    Methods: We searched the Cochrane Library, PubMed, MedRxiv, and EMBASE databases from December 2019 to July 15, 2020 for studies that evaluated the prevalence and impact of cardiac injury on COVID-19. This study has been registered with PROSPERO (International prospective register of systematic reviews)-registration number-CRD-42020186120.
    Results: Twenty-one studies including 6297 participants were identified. The proportions of cardiac injury were 22%, 28% among hospitalized patients with COVID-19 or severe COVID-19 patients, respectively. The incidences of cardiac injury in advance age (>60 years) (30%) was about two-fold than young patients (<60 years) (15%) with COVID-19. Severe cases (42%) have seven-fold prevalence cardiac injury than in their non- severe counterparts (6%). Furthermore, cardiac injury is associated with an increased risk of all-cause mortality in patients with COVID-19 (OR 10.11, 95% CI 4.49-22.77). In patients with severe COVID-19, cardiac injury is associated with an increased risk of all-cause mortality (OR: 16.79, 95% CI: 5.52-51.02).
    Conclusions: This was the first meta-analysis exploring the prevalence and impact of cardiac injury on COVID-19. Cardiac injury is common in hospitalized patients and advanced age and severe COVID-19 patients prone to experience more risk of cardiac injury. Furthermore, cardiac injury is associated with increased risk of all-cause mortality.
    MeSH term(s) COVID-19/complications ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/virology ; Humans ; Prevalence ; SARS-CoV-2
    Language English
    Publishing date 2020-12-31
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 391935-3
    ISSN 1932-8737 ; 0160-9289
    ISSN (online) 1932-8737
    ISSN 0160-9289
    DOI 10.1002/clc.23540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1423: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Coronavirus disease (COVID-19): A systematic review and meta-analysis to evaluate the impact of various comorbidities on serious events.

    Nandy, Kunal / Salunke, Abhijeet / Pathak, Subodh Kumar / Pandey, Apurva / Doctor, Chinmay / Puj, Ketul / Sharma, Mohit / Jain, Abhishek / Warikoo, Vikas

    Diabetes & metabolic syndrome

    2020  Volume 14, Issue 5, Page(s) 1017–1025

    Abstract: ... 66 and Chronic kidney disease with OR 5.32 had significant association in patients with COVID 19 ... we conducted a systematic review and meta-analysis to evaluate the impact of various morbidities on serious ... on April 28, 2020, to extract published articles that reported the outcomes of COVID-19 patients ...

    Abstract Background and aims: Currently there is limited knowledge on medical comorbidities and COVID-19; we conducted a systematic review and meta-analysis to evaluate the impact of various morbidities on serious events in COVID 19.
    Methods: PubMed, Cochrane Central Register of Clinical Trials were searched on April 28, 2020, to extract published articles that reported the outcomes of COVID-19 patients. The search terms were "coronavirus" and "clinical characteristics". ICU admission, mechanical ventilation, ARDS, Pneumonia, death was considered serious events. The comorbidities assessed in the study were Hypertension (HTN), Diabetes mellitus (DM), Cardiovascular diseases (CVD), Chronic obstructive pulmonary disease (COPD) and Chronic Kidney disease (CKD). Subsequently, comparisons between comorbidity patient group and the non-comorbidity patient groups, in terms of serious events were made using the pooled estimates of odd's ratio (OR) RESULTS: We identified 688 published results and 16 studies with 3994 patients were included in the systematic review. Serious events were seen in 526(13.16%) patients. Presence of hypertension with OR 2.95, diabetes mellitus with OR 3.07, Cardio vascular disease with OR 4.58, COPD with OR 6.66 and Chronic kidney disease with OR 5.32 had significant association in patients with COVID 19 on having serious events. Presence of diabetes mellitus (OR 2.78)) had a significant impact on death in COVID 19 patients with a p-value 0.004.
    Conclusions: Presence of medical comorbidities in COVID-19 leads to higher risk of developing serious events i.e. ICU admission, mechanical intubation and mortality. The presence of Diabetes mellitus has a significant impact on mortality rate in COVID-19 patients.
    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/physiopathology ; Comorbidity ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Coronavirus Infections/virology ; Diabetes Mellitus/mortality ; Diabetes Mellitus/physiopathology ; Hospitalization/statistics & numerical data ; Humans ; Hypertension/mortality ; Hypertension/physiopathology ; Incidence ; India ; Intensive Care Units/statistics & numerical data ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/virology ; Prognosis ; Pulmonary Disease, Chronic Obstructive/mortality ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Renal Insufficiency, Chronic/mortality ; Renal Insufficiency, Chronic/physiopathology ; Risk Factors ; SARS-CoV-2 ; Survival Rate
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2273766-2
    ISSN 1878-0334 ; 1871-4021
    ISSN (online) 1878-0334
    ISSN 1871-4021
    DOI 10.1016/j.dsx.2020.06.064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impact of cardiovascular disease and risk factors on fatal outcomes in patients with COVID-19 according to age: a systematic review and meta-analysis.

    Bae, SungA / Kim, So Ree / Kim, Mi-Na / Shim, Wan Joo / Park, Seong-Mi

    Heart (British Cardiac Society)

    2020  Volume 107, Issue 5, Page(s) 373–380

    Abstract: ... its risk factors on fatal outcomes according to age in patients with COVID-19.: Methods: A systematic ... diabetes) were closely related to fatal outcomes in COVID-19 for patients across all ages. Although young ... literature review and meta-analysis was performed on data collected from PubMed and Embase databases up to 11 June ...

    Abstract Objective: Previous studies that evaluated cardiovascular risk factors considered age as a potential confounder. We aimed to investigate the impact of cardiovascular disease (CVD) and its risk factors on fatal outcomes according to age in patients with COVID-19.
    Methods: A systematic literature review and meta-analysis was performed on data collected from PubMed and Embase databases up to 11 June 2020. All observational studies (case series or cohort studies) that assessed in-hospital patients were included, except those involving the paediatric population. Prevalence rates of comorbid diseases and clinical outcomes were stratified by mean patient age in each study (ranges: <50 years, 50-60 years and ≥60 years). The primary outcome measure was a composite fatal outcome of severe COVID-19 or death.
    Results: We included 51 studies with a total of 48 317 patients with confirmed COVID-19 infection. Overall, the relative risk of developing severe COVID-19 or death was significantly higher in patients with risk factors for CVD (hypertension: OR 2.50, 95% CI 2.15 to 2.90; diabetes: 2.25, 95% CI 1.89 to 2.69) and CVD (3.11, 95% 2.55 to 3.79). Younger patients had a lower prevalence of hypertension, diabetes and CVD compared with older patients; however, the relative risk of fatal outcomes was higher among the former.
    Conclusions: The results of the meta-analysis suggest that CVD and its risk factors (hypertension and diabetes) were closely related to fatal outcomes in COVID-19 for patients across all ages. Although young patients had lower prevalence rates of cardiovascular comorbidities than elderly patients, relative risk of fatal outcome in young patients with hypertension, diabetes and CVD was higher than in elderly patients.
    Prospero registration number: CRD42020198152.
    MeSH term(s) COVID-19/mortality ; Cardiovascular Diseases/epidemiology ; Heart Disease Risk Factors ; Humans ; Mortality
    Language English
    Publishing date 2020-12-17
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2020-317901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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