Article ; Online: Risk of missing colorectal cancer with a COVID-adapted diagnostic pathway using quantitative faecal immunochemical testing.
BJS open
2021 Volume 5, Issue 4
Abstract: ... COVID-adapted pathway for suspected bowel cancer combines two quantitative faecal immunochemical tests ... Decision-tree models were developed using a combination of data from the COVID-adapted pathway (April-May 2020 ... Results: The COVID-adapted pathway included 422 patients, whereas the audit of qFIT included more ...
| Abstract | Background: COVID-19 has brought an unprecedented challenge to healthcare services. The authors' COVID-adapted pathway for suspected bowel cancer combines two quantitative faecal immunochemical tests (qFITs) with a standard CT scan with oral preparation (CT mini-prep). The aim of this study was to estimate the degree of risk mitigation and residual risk of undiagnosed colorectal cancer. Method: Decision-tree models were developed using a combination of data from the COVID-adapted pathway (April-May 2020), a local audit of qFIT for symptomatic patients performed since 2018, relevant data (prevalence of colorectal cancer and sensitivity and specificity of diagnostic tools) obtained from literature and a local cancer data set, and expert opinion for any missing data. The considered diagnostic scenarios included: single qFIT; two qFITs; single qFIT and CT mini-prep; two qFITs and CT mini-prep (enriched pathway). These were compared to the standard diagnostic pathway (colonoscopy or CT virtual colonoscopy (CTVC)). Results: The COVID-adapted pathway included 422 patients, whereas the audit of qFIT included more than 5000 patients. The risk of missing a colorectal cancer, if present, was estimated as high as 20.2 per cent with use of a single qFIT as a triage test. Using both a second qFIT and a CT mini-prep as add-on tests reduced the risk of missed cancer to 6.49 per cent. The trade-off was an increased rate of colonoscopy or CTVC, from 287 for a single qFIT to 418 for the double qFIT and CT mini-prep combination, per 1000 patients. Conclusion: Triage using qFIT alone could lead to a high rate of missed cancers. This may be reduced using CT mini-prep as an add-on test for triage to colonoscopy or CTVC. |
|---|---|
| MeSH term(s) | COVID-19 ; Clinical Audit ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Decision Trees ; Diagnostic Errors/statistics & numerical data ; Early Detection of Cancer/methods ; Humans ; Occult Blood ; Scotland ; Sensitivity and Specificity ; Tomography, X-Ray Computed ; Triage/organization & administration |
| Language | English |
| Publishing date | 2021-08-24 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 2474-9842 |
| ISSN (online) | 2474-9842 |
| DOI | 10.1093/bjsopen/zrab056 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Inter-library loan at ZB MED
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.