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  1. Article: Clinical Presentation of Cases with SARS-CoV-2 Reinfection/ Reactivation.

    Mahajan, Niraj N / Gajbhiye, Rahul K / Lokhande, Pradip D / Bahirat, Shubhada / Modi, Deepak / Mathe, Apeksha M / Bharmal, Ramesh / Rathi, Surbhi / Mohite, Shailesh C / Tilve, Arundhati

    The Journal of the Association of Physicians of India

    2021  Volume 69, Issue 1, Page(s) 16–18

    Abstract: Background: Reinfection/reactivation of SARS-CoV-2 has been a matter of great interest ... the patients took to become SARS-CoV-2 negative by RT-CPR and/or clinically recover in the first episode and ... characteristics of 9 healthcare workers (HCWs) with two episodes of SARS-CoV-2 are described.: Results ...

    Abstract Background: Reinfection/reactivation of SARS-CoV-2 has been a matter of great interest from the immunological and vaccine perspective. However, little is known about the clinical presentation of such reinfection/reactivation. We report a case series of 9 COVID-19 patients having experienced two clinically- and/or virologically-confirmed episodes of COVID-19.
    Methods: Epidemiological and clinical characteristics of 9 healthcare workers (HCWs) with two episodes of SARS-CoV-2 are described.
    Results: The incidence of reinfection/reactivation amongst the HCWs was 2% (9 out of 491) with an average remission period of 66 days (range 43-78 days). Amongst the cases of reinfection 4/9 were asymptomatic in first episode were symptomatic in second episode. There is negative correlation between numbers of days the patients took to become SARS-CoV-2 negative by RT-CPR and/or clinically recover in the first episode and the second episode irrespective for the time spent in remission.
    Conclusion: Shorter durations of SARS-COV-2 infection in the first episode are associated with longer time to recovery in the second episode in patients with re-infection/reactivation.
    MeSH term(s) COVID-19 ; Health Personnel ; Humans ; Reinfection ; SARS-CoV-2 ; Time Factors
    Language English
    Publishing date 2021-07-06
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical characteristics of SARS-CoV-2 by re-infection vs. reactivation: a case series from Iran.

    Salehi-Vaziri, Mostafa / Jalali, Tahmineh / Farahmand, Behrokh / Fotouhi, Fatemeh / Banifazl, Mohammad / Pouriayevali, Mohammad Hassan / Sadat Larijani, Mona / Afzali, Neda / Ramezani, Amitis

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2021  Volume 40, Issue 8, Page(s) 1713–1719

    Abstract: ... in the second infection. All cases were found IgG positive in the re-infection phase. The sequencing of SARS-CoV ... of SARS-CoV-2 infection was different among the investigated subjects who experienced an interval between ... significant effect on clinical implications and also vaccination. Our data supports clear warning of SARS-CoV ...

    Abstract COVID-19 immunity in infected individuals may not be persistent. The specific response wanes in patients who have recovered from this infection. Nevertheless, it has not been fully understood whether true re-infection occurs or the viral reactivation. In this study, we investigated three COVID-19 patients who represented the symptoms after recovery. Chest CT scan was applied to assess the patients along with the viral samples from oropharyngeal/nasopharyngeal which were subjected to RT-PCR. The viral genome sequencing was applied where possible to distinguish possible re-infection or latent reactivation. Moreover, COVID-19-specific antibodies available data were evaluated in each incidence. The second episode of SARS-CoV-2 infection was different among the investigated subjects who experienced an interval between positive PCR tests ranged between 63 and 156 days. The disease presentation was less or more severe in the second infection. All cases were found IgG positive in the re-infection phase. The sequencing of SARS-CoV-2 sample obtained from two cases revealed a D614G mutation of S gene from the second isolated sample strengthens the case for the re-infection. The possibility of re-infection and reactivation could have significant effect on clinical implications and also vaccination. Our data supports clear warning of SARS-CoV-2 continuous circulation potency among the populations in spite of herd immunity either with natural infection or vaccination. This issue is critical in term of the patients, clinical investigate, and viral transmission.
    MeSH term(s) Adult ; Antibodies, Viral/blood ; Base Sequence ; COVID-19/diagnosis ; Female ; Genome, Viral ; Humans ; Immunoglobulin G/blood ; Iran ; Male ; Middle Aged ; Reinfection/virology ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics ; Virus Activation
    Chemical Substances Antibodies, Viral ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-03-18
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-021-04221-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1732: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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