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Article ; Online: Remote but not isolated.

Mair, William B

Translational medicine of aging

2020 Volume 4, Page(s) 86–87

Abstract: I helped organized an online seminar series for 1500 people with no planning. Here are some thoughts on how it went, what we learned, and how it might shape in person meetings in the future. ...

Abstract	I helped organized an online seminar series for 1500 people with no planning. Here are some thoughts on how it went, what we learned, and how it might shape in person meetings in the future.
Keywords	covid19
Language	English
Publishing date	2020-06-30
Publishing country	Netherlands
Document type	Journal Article
ISSN	2468-5011
ISSN (online)	2468-5011
DOI	10.1016/j.tma.2020.06.001
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Article: Remote but not isolated

Mair, William B.

Translational Medicine of Aging

Abstract: I helped organized an online seminar series for 1500 people by with no planning Here is are some thoughts on how it went, what we learned, and how it might shape in person meetings in the ... ...

Abstract	I helped organized an online seminar series for 1500 people by with no planning Here is are some thoughts on how it went, what we learned, and how it might shape in person meetings in the future
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #627550
Database	COVID19

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Article ; Online: Remote but not isolated

William B. Mair

Translational Medicine of Aging, Vol 4, Iss , Pp 86-

2020 Volume 87

Abstract	I helped organized an online seminar series for 1500 people with no planning. Here are some thoughts on how it went, what we learned, and how it might shape in person meetings in the future.
Keywords	Aging ; Training ; Mentoring ; Collaboration ; Zoombombs ; Medicine ; R
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Remote, but Not Isolated—Microplastics in the Sub-surface Waters of the Canadian Arctic Archipelago

Kirstie Jones-Williams / Tamara S. Galloway / Victoria L. Peck / Clara Manno

Frontiers in Marine Science, Vol

2021 Volume 8

Abstract: As the remote Canadian Arctic Archipelago (CAA) becomes increasingly connected to the rest ... for increases in localised sources of plastic pollution resulting from the increasing navigability of the remote ...

Abstract	As the remote Canadian Arctic Archipelago (CAA) becomes increasingly connected to the rest of the world, there is an impetus to monitor the possible impact of this connectivity. The potential for increases in localised sources of plastic pollution resulting from the increasing navigability of the remote north has yet to be explored. Here we investigate microplastic samples which were collected aboard the Canadian Coast Guard Ship (CCGS) Amundsen in the summer of 2018 using the underway pump and a filtration system with Fourier transform infrared analysis. We investigate the character, abundance, and distribution of microplastic particles and fibres in the sub-surface waters across the Canadian Arctic and add to the limited dataset on plastic pollution in this region. We find that there are low concentrations of microplastics ranging from 0 to 0.282 n L–1 (average 0.031 ± 0.017 n L–1), comprising 71% polyester and acrylics. We investigate the size distribution of retained particles and fibres on three different filter mesh sizes connected to the underway pump (300, 100, and 50 μm) and find that a 300 μm mesh and a 100 μm mesh retain only 6 and 56%, respectively, of the total particles and fibres. We explore the role of shipping as a potential source of textile fibres and we suggest that future monitoring of plastics in the Canadian Arctic should use the current shipping fleet to monitor its own plastic footprint, utilising the underway pump and mesh sizes < 100 μm.
Keywords	microplastic ; microfibre ; Arctic ; Canada ; sub-surface ; environmental monitoring ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
Subject code	551
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Host specificity shapes fish viromes across lakes on an isolated remote island.

Grimwood, Rebecca M / Fortune-Kelly, Grace / Holmes, Edward C / Ingram, Travis / Geoghegan, Jemma L

Virology

2023 Volume 587, Page(s) 109884

Abstract: ... Rēkohu), a geographically isolated island housing 9% of New Zealand's threatened endemic fish species ... between host and virus despite their unique and geographically isolated ecosystem. ... was not influenced by the ecological factors measured and smelt (Retropinna retropinna) viromes were ...

Abstract	Fish viromes often provide insights into the origin and evolution of viruses affecting tetrapods, including those associated with imporant human diseases. However, despite fish being the most diverse vertebrate group, their viruses are still understudied. We investigated the viromes of fish on Chatham Island (Rēkohu), a geographically isolated island housing 9% of New Zealand's threatened endemic fish species. Using metatranscriptomics, we analyzed samples from seven host species across 16 waterbodies. We identified 19 fish viruses, including 16 potentially novel species, expanding families such as the Coronaviridae, Hantaviridae, Poxviridae, and the recently proposed Tosoviridae. Surprisingly, virome composition was not influenced by the ecological factors measured and smelt (Retropinna retropinna) viromes were consistent across lakes despite differences in host life history, seawater influence, and community richness. Overall, fish viromes across Rēkohu were highly diverse and revealed a long history of co-divergence between host and virus despite their unique and geographically isolated ecosystem.
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	200425-2
ISSN	1096-0341 ; 0042-6822
ISSN (online)	1096-0341
ISSN	0042-6822
DOI	10.1016/j.virol.2023.109884
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Article: Remote, tablet-based assessment of gaze following: a nationwide infant twin study.

Shic, Frederick / Dommer, Kelsey Jackson / Benton, Jessica / Li, Beibin / Snider, James C / Nyström, Par / Falck-Ytter, Terje

Frontiers in psychology

2023 Volume 14, Page(s) 1223267

Abstract: ... tracking, we found that a full head movement elicited more gaze following than isolated eye movements ... solution is the development of new, remotely deployed assessment tools that do not require real-time ... of remote assessment of infants' psychological development, which can improve generalizability, inclusion ...

Abstract	Introduction: Much of our understanding of infant psychological development relies on an in-person, laboratory-based assessment. This limits research generalizability, scalability, and equity in access. One solution is the development of new, remotely deployed assessment tools that do not require real-time experimenter supervision. Methods: The current nationwide (Sweden) infant twin study assessed participants remotely via their caregiver's tablets ( Results: Closely mimicking results from conventional eye tracking, we found that a full head movement elicited more gaze following than isolated eye movements. Furthermore, predictably, we found that older infants followed gaze more frequently than younger infants. Finally, while we found no indication of genetic contributions to gaze-following accuracy, the latency to disengage from the gaze cue and orient toward a target was significantly more similar in monozygotic twins than in dizygotic twins, an indicative of heritability. Discussion: Together, these results highlight the potential of remote assessment of infants' psychological development, which can improve generalizability, inclusion, and scalability in developmental research.
Language	English
Publishing date	2023-10-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1223267
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Article ; Online: Extracellular vesicles isolated from patients undergoing remote ischemic preconditioning decrease hypoxia-evoked apoptosis of cardiomyoblasts after isoflurane but not propofol exposure.

Abel, Frederik / Murke, Florian / Gaida, Morten / Garnier, Nicolas / Ochsenfarth, Crista / Theiss, Carsten / Thielmann, Matthias / Kleinbongard, Petra / Giebel, Bernd / Peters, Jürgen / Frey, Ulrich H

PloS one

2020 Volume 15, Issue 2, Page(s) e0228948

Abstract: ... and this may depend on the anesthetic used. We tested whether 1) extracellular vesicles (EVs) isolated ... altered by cardiomyoblast exposure to isoflurane or propofol. EVs were isolated before and 60 min after ... Apoptotic ratio: 1.01; Sham-EVs/control, apoptotic ratio: 0.94; p = 0.602). Thus, EVs isolated from patients ...

Abstract	Remote ischemic preconditioning (RIPC) can evoke cardioprotection following ischemia/reperfusion and this may depend on the anesthetic used. We tested whether 1) extracellular vesicles (EVs) isolated from humans undergoing RIPC protect cardiomyoblasts against hypoxia-induced apoptosis and 2) this effect is altered by cardiomyoblast exposure to isoflurane or propofol. EVs were isolated before and 60 min after RIPC or Sham from ten patients undergoing coronary artery bypass graft surgery with isoflurane anesthesia and quantified by Nanoparticle Tracking Analysis. Following EV-treatment for 6 hours under exposure of isoflurane or propofol, rat H9c2 cardiomyoblasts were cultured for 18 hours in normoxic or hypoxic atmospheres. Apoptosis was detected by flow cytometry. Serum nanoparticle concentrations in patients had increased sixty minutes after RIPC compared to Sham (2.5x1011±4.9x1010 nanoparticles/ml; Sham: 1.2x1011±2.0x1010; p = 0.04). Hypoxia increased apoptosis of H9c2 cells (hypoxia: 8.4%±0.6; normoxia: 2.5%±0.1; p<0.0001). RIPC-EVs decreased H9c2 cell apoptosis compared to control (apoptotic ratio: 0.83; p = 0.0429) while Sham-EVs showed no protection (apoptotic ratio: 0.97). Prior isoflurane exposure in vitro even increased protection (RIPC-EVs/control, apoptotic ratio: 0.79; p = 0.0035; Sham-EVs/control, apoptotic ratio:1.04) while propofol (50μM) abrogated protection by RIPC-EVs (RIPC-EVs/control, Apoptotic ratio: 1.01; Sham-EVs/control, apoptotic ratio: 0.94; p = 0.602). Thus, EVs isolated from patients undergoing RIPC under isoflurane anesthesia protect H9c2 cardiomyoblasts against hypoxia-evoked apoptosis and this effect is abrogated by propofol. This supports a role of human RIPC-generated EVs in cardioprotection and underlines propofol as a possible confounder in RIPC-signaling mediated by EVs.
MeSH term(s)	Aged ; Anesthesia/methods ; Animals ; Apoptosis/physiology ; Coronary Artery Bypass/methods ; Extracellular Vesicles/metabolism ; Extracellular Vesicles/physiology ; Female ; Humans ; Hypoxia/metabolism ; Ischemia/metabolism ; Ischemic Preconditioning/methods ; Isoflurane/pharmacology ; Male ; Middle Aged ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/physiology ; Propofol/pharmacology ; Rats
Chemical Substances	Isoflurane (CYS9AKD70P) ; Propofol (YI7VU623SF)
Language	English
Publishing date	2020-02-14
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0228948
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Article ; Online: An exploration of extreme obesity and weight loss management for adults in rural, remote, and regional areas: a systematic review.

Summers, Rachael / Lea, Jackie / East, Leah

Contemporary nurse

2024 Volume 60, Issue 1, Page(s) 54–66

Abstract: ... in geographically isolated locations. The success of mainstream weight loss strategies such as surgery, exercise ... obesity for isolated locations linked to gender, culture, and poor mental health. Individualised and ... with extreme obesity within geographically isolated locations and losing weight is challenging for women ...

Abstract	Background: Extreme obesity is a global health issue impacting health and related health outcomes. Although extreme obesity is prevalent across all geographical settings, the condition is more common in geographically isolated locations. The success of mainstream weight loss strategies such as surgery, exercise, and dietary information within these communities remains unknown, and it is unclear if isolation facilitates or hinders treatment for weight management. Aim: This review aimed to identify common themes around weight loss and health and social impacts for extremely obese adults living in rural, remote, and regional locations. Methods: A systematic literature review of peer-reviewed publications from May 2013 to May 2023 was undertaken and appraised using the Mixed Method Appraisal Tool (MMAT). Sequential synthesis was thematically analysed and described within a narrative account. Earlier dates were not included as initial research indicated a global surge in obesity within the early 2010s (Wang, Y., Beydoun, M. A., Min, J., Xue, H., Kaminsky, L. A., & Cheskin, L. J. (2020). Has the prevalence of overweight, obesity and central obesity levelled off in the United States? Trends, patterns, disparities, and future projections for the obesity epidemic. Results: This review identified 13 studies that reported negative trends in extreme obesity for isolated locations linked to gender, culture, and poor mental health. Individualised and community models of weight loss support can be positive for certain demographic groups, specifically females, through the promotion of cost-effective, and locally available traditional food choices. Conclusion: Living with extreme obesity within geographically isolated locations and losing weight is challenging for women, Indigenous peoples, and people with low literacy and those from lower socio-economic backgrounds. Generalised advice about weight loss is often unsuccessful; however, weight loss is achievable with consumer engagement which considers the influence and impact of rurality. Further research focusing on individualised nursing models for managing morbid obesity within isolated locations is required.
MeSH term(s)	Adult ; Humans ; Female ; United States ; Obesity, Morbid/therapy ; Weight Loss ; Overweight
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1491361-6
ISSN	1839-3535 ; 1037-6178
ISSN (online)	1839-3535
ISSN	1037-6178
DOI	10.1080/10376178.2024.2304712
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Article ; Online: Pulsation waves along the Ciona heart tube reverse by bimodal rhythms expressed by a remote pair of pacemakers.

Fujikake, Yuma / Fukuda, Kéita / Matsushita, Katsuyoshi / Iwatani, Yasushi / Fujimoto, Koichi / Nishino, Atsuo S

The Journal of experimental biology

2024 Volume 227, Issue 10

Abstract: ... a series of experiments to characterize the pacemaker systems in isolated hearts and their fragments, and ... applied a mathematical model to examine the conditions leading to heart reversals. The isolated heart ... min intervals. Experimental bisections of isolated hearts revealed that independent pacemakers resided ...

Abstract	The heart of ascidians (marine invertebrate chordates) has a tubular structure, and heartbeats propagate from one end to the other. The direction of pulsation waves intermittently reverses in the heart of ascidians and their relatives; however, the underlying mechanisms remain unclear. We herein performed a series of experiments to characterize the pacemaker systems in isolated hearts and their fragments, and applied a mathematical model to examine the conditions leading to heart reversals. The isolated heart of Ciona robusta autonomously generated pulsation waves at ∼20 to 25 beats min-1 with reversals at ∼1 to 10 min intervals. Experimental bisections of isolated hearts revealed that independent pacemakers resided on each side and also that their beating frequencies periodically changed as they expressed bimodal rhythms, which comprised an ∼1.25 to 5.5 min acceleration/deceleration cycle of a beating rate of between 0 and 25 beats min-1. Only fragments including 5% or shorter terminal regions of the heart tube maintained autonomous pulsation rhythms, whereas other regions did not. Our mathematical model, based on FitzHugh-Nagumo equations applied to a one-dimensional alignment of cells, demonstrated that the difference between frequencies expressed by the two independent terminal pacemakers determined the direction of propagated waves. Changes in the statuses of terminal pacemakers between the excitatory and oscillatory modes as well as in their endogenous oscillation frequencies were sufficient to lead to heart reversals. These results suggest that the directions of pulsation waves in the Ciona heart reverse according to the changing rhythms independently expressed by remotely coupled terminal pacemakers.
MeSH term(s)	Animals ; Heart/physiology ; Biological Clocks/physiology ; Ciona intestinalis/physiology ; Heart Rate
Language	English
Publishing date	2024-05-21
Publishing country	England
Document type	Journal Article
ZDB-ID	218085-6
ISSN	1477-9145 ; 0022-0949
ISSN (online)	1477-9145
ISSN	0022-0949
DOI	10.1242/jeb.246810
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Article ; Online: Mixed methods to evaluate knowledge, attitudes and practices (KAP) towards rabies in central and remote communities of Moramanga district, Madagascar.

Leblanc, Claire / Kassié, Daouda / Ranaivoharimina, Mendrika / Rakotomanana, Elliot Fara Nandrasana / Mangahasimbola, Reziky Tiandraza / Randrianarijaona, Anjasoa / Ramiandrasoa, Ravo / Nely, Alphonse José / Razafindraibe, Nivohanitra Perle / Andriamandimby, Soa Fy / Ranoaritiana, Dany Bakoly / Rajaonarivony, Virginie / Randrianasolo, Laurence / Baril, Laurence / Mattern, Chiarella / Ratovoson, Rila / Guis, Hélène

PLoS neglected tropical diseases

2024 Volume 18, Issue 3, Page(s) e0012064

Abstract: ... to PEP (92.2%) or that biting dogs should be isolated (89.5%) and monitored. Good knowledge scores were ... respondents were not aware of the existence of the ARTC (85.3%), did not know the importance of timely access ... They should also encourage owners to isolate and monitor the health of biting dogs. Above all, awareness and dog ...

Abstract	Control of dog-mediated rabies relies on raising awareness, access to post-exposure prophylaxis (PEP) and mass dog vaccination. To assess rabies awareness in Moramanga district, Madagascar, where rabies is endemic, two complementary quantitative and qualitative approaches were carried out in 2018. In the quantitative approach, a standardized questionnaire was administered to 334 randomized participants living in 170 households located less than 5 km from the anti-rabies treatment center (ARTC) located in Moramanga city (thereafter called the central area), and in 164 households located more than 15 km away from the ARTC in two rural communes (thereafter called the remote area). Logistic regression models were fitted to identify factors influencing knowledge and practice scores. The qualitative approach consisted in semi-structured interviews conducted with 28 bite victims who had consulted the ARTC, three owners of biting dogs, three ARTC staff and two local authorities. Overall, 15.6% (52/334) of households owned at least one dog. The dog-to-human ratio was 1:17.6. The central area had a significantly higher dog bite incidence (0.53 per 100 person-years, 95% CI: 0.31-0.85) compared to the remote area (0.22 per 100 person-years, 95% CI: 0.09-0.43) (p = 0.03). The care pathway following a bite depended on wound severity, how the dog was perceived and its owner's willingness to cover costs. Rabies vaccination coverage in dogs in the remote area was extremely low (2.4%). Respondents knew that vaccination prevented animal rabies but owners considered that their own dogs were harmless and cited access and cost of vaccine as main barriers. Most respondents were not aware of the existence of the ARTC (85.3%), did not know the importance of timely access to PEP (92.2%) or that biting dogs should be isolated (89.5%) and monitored. Good knowledge scores were significantly associated with having a higher socio-economic status (OR = 2.08, CI = 1.33-3.26) and living in central area (OR = 1.91, CI = 1.22-3.00). Good practice scores were significantly associated with living in central area (OR = 4.78, CI = 2.98-7.77) and being aware of the ARTC's existence (OR = 2.29, CI = 1.14-4.80). In Madagascar, knowledge on rabies was disparate with important gaps on PEP and animal management. Awareness campaigns should inform communities (i) on the importance of seeking PEP as soon as possible after an exposure, whatever the severity of the wound and the type of biting dog who caused it, and (ii) on the existence and location of ARTCs where free-of-charge PEP is available. They should also encourage owners to isolate and monitor the health of biting dogs. Above all, awareness and dog vaccination campaigns should be designed so as to reach the more vulnerable remote rural populations as knowledge, good practices and vaccination coverage were lower in these areas. They should also target households with a lower socio-economic status. If awareness campaigns are likely to succeed in improving access to ARTCs in Madagascar, their impact on prompting dog owners to vaccinate their own dogs seems more uncertain given the financial and access barriers. Therefore, to reach the 70% dog vaccination coverage goal targeted in rabies elimination programs, awareness campaigns must be combined with free-of-charge mass dog vaccination.
MeSH term(s)	Humans ; Animals ; Dogs ; Rabies/epidemiology ; Rabies/prevention & control ; Rabies/veterinary ; Madagascar/epidemiology ; Health Knowledge, Attitudes, Practice ; Dog Diseases/prevention & control ; Dog Diseases/epidemiology ; Rabies Vaccines ; Bites and Stings
Chemical Substances	Rabies Vaccines
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0012064
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