Article ; Online: Distorted chemosensory perception and female sex associate with persistent smell and/or taste loss in people with SARS-CoV-2 antibodies: a community based cohort study investigating clinical course and resolution of acute smell and/or taste loss in people with and without SARS-CoV-2 antibodies in London, UK.
BMC infectious diseases
2021 Volume 21, Issue 1, Page(s) 221
Abstract: ... Female participants with SARS-CoV-2 antibodies and unresolved smell loss and unresolved taste loss were ... hundred sixty-seven participants with acute loss of smell and/or taste who had undergone SARS-CoV-2 IgG ... to subjective smell evaluations.: Results: People with SARS-CoV-2 antibodies with an acute loss of sense ...
| Abstract | Background: Loss of smell and/or taste are cardinal symptoms of COVID-19. 'Long-COVID', persistence of symptoms, affects around one fifth of people. However, data regarding the clinical resolution of loss of smell and/or taste are lacking. In this study we assess smell and taste loss resolution at 4-6 week follow-up, aim to identify risk factors for persistent smell loss and describe smell loss as a feature of long-COVID in a community cohort in London with known SARS-CoV-2 IgG/IgM antibody status. We also compare subjective and objective smell assessments in a subset of participants. Methods: Four hundred sixty-seven participants with acute loss of smell and/or taste who had undergone SARS-CoV-2 IgG/IgM antibody testing 4-6 weeks earlier completed a follow-up questionnaire about resolution of their symptoms. A subsample of 50 participants completed an objective olfactory test and results were compared to subjective smell evaluations. Results: People with SARS-CoV-2 antibodies with an acute loss of sense of smell and taste were significantly less likely to recover their sense of smell/taste than people who were seronegative (smell recovery: 57.7% vs. 72.1%, p = 0.027. taste recovery 66.2% vs. 80.3%, p = 0.017). In SARS-CoV-2 positive participants, a higher percentage of male participants reported full resolution of smell loss (72.8% vs. 51.4%; p < 0.001) compared to female participants, who were almost 2.5-times more likely to have ongoing smell loss after 4-6 weeks (OR 2.46, 95%CI 1.47-4.13, p = 0.001). Female participants with SARS-CoV-2 antibodies and unresolved smell loss and unresolved taste loss were significantly older (> 40 years) than those who reported full resolution. Participants who experienced parosmia reported lower smell recovery rates and participants with distorted taste perception lower taste recovery rates. Parosmia had a significant association to unresolved smell loss (OR 2.47, 95%CI 1.54-4.00, p < 0.001). Conclusion: Although smell and/or taste loss are often transient manifestations of COVID-19, 42% of participants had ongoing loss of smell, 34% loss of taste and 36% loss of smell and taste at 4-6 weeks follow-up, which constitute symptoms of 'long-COVID'. Females (particularly > 40 years) and people with a distorted perception of their sense of smell/taste are likely to benefit from prioritised early therapeutic interventions. Trials registration: ClinicalTrials.gov NCT04377815 Date of registration: 23/04/2020. |
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| MeSH term(s) | Adult ; Ageusia/etiology ; Antibodies, Viral/blood ; COVID-19/complications ; Cohort Studies ; Female ; Humans ; Immunoglobulin M/blood ; London ; Male ; Middle Aged ; Olfaction Disorders/diagnosis ; Olfaction Disorders/etiology ; SARS-CoV-2 ; Sex Factors ; Smell ; Surveys and Questionnaires ; Treatment Outcome |
| Chemical Substances | Antibodies, Viral ; Immunoglobulin M |
| Language | English |
| Publishing date | 2021-02-25 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 1471-2334 |
| ISSN (online) | 1471-2334 |
| DOI | 10.1186/s12879-021-05927-w |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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