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  1. Article: Impact of Prediabetes and Type-2 Diabetes on Outcomes in Patients with COVID-19.

    Makker, Jasbir / Sun, Haozhe / Patel, Harish / Mantri, Nikhitha / Zahid, Maleeha / Gongati, Sudharsan / Galiveeti, Sneha / Renner, Sharon W / Chilimuri, Sridhar

    International journal of endocrinology

    2021  Volume 2021, Page(s) 5516192

    Abstract: Introduction: The true impact of prediabetes and type-2 diabetes in patients with COVID-19 remains ... Conclusion: In older patients aged 55 years and above, status of type-2 diabetes does not influence ... 2 diabetes, may have better survival. Presence of prediabetes did not affect outcomes in patients ...

    Abstract Introduction: The true impact of prediabetes and type-2 diabetes in patients with COVID-19 remains unknown, with studies thus far providing conflicting evidence.
    Methods: This is a single-center retrospective observational study involving 843 hospitalized patients with SARS-CoV-2 infection. Primary outcomes, mortality, and mechanical ventilation use were compared among the three groups: control, prediabetes, and type-2 diabetes. Binomial regression analysis was used to determine predictors of mortality and mechanical ventilation requirement.
    Results: Age was a significant predictor of mortality. On stratifying our patients based on their age, older patients aged 55 years and above had no difference in mortality or mechanical ventilation requirement among the three groups of control, prediabetes, and type-2 diabetes. However, among the younger population aged less than 55 years, patients with type-2 diabetes had significantly higher mortality as compared with patients in control and prediabetes groups (27% vs 12.5% vs 9%,
    Conclusion: In older patients aged 55 years and above, status of type-2 diabetes does not influence their mortality. However, in younger patients aged less than 55 years, the presence of type-2 diabetes is an important driver of mortality. Newly diagnosed type-2 diabetes, in comparison with previously diagnosed type-2 diabetes, may have better survival. Presence of prediabetes did not affect outcomes in patients with COVID-19 infection.
    Language English
    Publishing date 2021-06-16
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2502951-4
    ISSN 1687-8345 ; 1687-8337
    ISSN (online) 1687-8345
    ISSN 1687-8337
    DOI 10.1155/2021/5516192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Impact of pre-existing type 2 diabetes with and without cardiovascular disease on patients with COVID-19.

    Nguyen, Chi / Crowe, Christopher L / Kuti, Effie / Narsipur, Nihal / Donato, Bonnie / Pepe, Rebecca S / Djaraher, Rachel / Seman, Leo / Graeter, Nancy / Power, Thomas P / Mehra, Rinku / Willey, Vincent J

    Diabetes, obesity & metabolism

    2023  Volume 25, Issue 9, Page(s) 2464–2472

    Abstract: Aim: To compare adverse outcomes among COVID-19 patients with pre-existing type 2 diabetes (T2D ... Database. Patients with COVID-19 were identified from 3 January 2020 to 31 May 2021 and stratified ... associated with pre-existing T2D + CVD in COVID-19 patients compared with those without T2D/CVD and suggests ...

    Abstract Aim: To compare adverse outcomes among COVID-19 patients with pre-existing type 2 diabetes (T2D) only, T2D and cardiovascular disease (CVD), or neither.
    Methods: This retrospective cohort study used administrative claims, laboratory and mortality data from the HealthCore Integrated Research Database. Patients with COVID-19 were identified from 3 January 2020 to 31 May 2021 and stratified by the presence of T2D and CVD. Outcomes included hospitalization, intensive care unit (ICU) admission, mortality and complications following COVID-19 infection. Propensity score matching and multivariable analyses were performed.
    Results: A total of 321 232 COVID-19 patients were identified (21 651 T2D + CVD, 28 184 T2D only, and 271 397 neither) with a mean (SD) follow-up of 5.4 (3.0) months. After matching, 6 967 patients were identified for each group, and residual baseline differences remained. Adjusted analyses showed that COVID-19 patients with T2D + CVD were 59% more probable to be hospitalized, 74% more probable to be admitted to the ICU, and had a 26% higher mortality risk than those with neither. COVID-19 patients with T2D only were 28% and 32% more probable to be admitted to the hospital and ICU than those with neither, respectively. Among all T2D + CVD patients, acute respiratory distress syndrome (31%) and acute kidney disease (24%) were observed.
    Conclusion: Our study highlights the incrementally poorer outcomes associated with pre-existing T2D + CVD in COVID-19 patients compared with those without T2D/CVD and suggests consideration of a more optimal management approach in these patients.
    MeSH term(s) Humans ; COVID-19/complications ; COVID-19/epidemiology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Retrospective Studies ; Cardiovascular Diseases/complications ; Cardiovascular Diseases/epidemiology ; Prediabetic State/complications
    Language English
    Publishing date 2023-06-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5442: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Impact of undiagnosed type 2 diabetes and pre-diabetes on severity and mortality for SARS-CoV-2 infection.

    Vargas-Vázquez, Arsenio / Bello-Chavolla, Omar Yaxmehen / Ortiz-Brizuela, Edgar / Campos-Muñoz, Alejandro / Mehta, Roopa / Villanueva-Reza, Marco / Bahena-López, Jessica Paola / Antonio-Villa, Neftali Eduardo / González-Lara, María Fernanda / Ponce de León, Alfredo / Sifuentes-Osornio, Jose / Aguilar-Salinas, Carlos Alberto

    BMJ open diabetes research & care

    2021  Volume 9, Issue 1

    Abstract: ... hospitalized patients with undiagnosed type 2 diabetes and pre-diabetes to evaluate its impact on adverse COVID ... to model risk for COVID-19 outcomes.: Results: Overall, 159 cases (50.2%) had type 2 diabetes and 125 ... Introduction: Diabetes and hyperglycemia are risk factors for critical COVID-19 outcomes ...

    Abstract Introduction: Diabetes and hyperglycemia are risk factors for critical COVID-19 outcomes; however, the impact of pre-diabetes and previously unidentified cases of diabetes remains undefined. Here, we profiled hospitalized patients with undiagnosed type 2 diabetes and pre-diabetes to evaluate its impact on adverse COVID-19 outcomes. We also explored the role of de novo and intrahospital hyperglycemia in mediating critical COVID-19 outcomes.
    Research design and methods: Prospective cohort of 317 hospitalized COVID-19 cases from a Mexico City reference center. Type 2 diabetes was defined as previous diagnosis or treatment with diabetes medication, undiagnosed diabetes and pre-diabetes using glycosylated hemoglobin (HbA1c) American Diabetes Association (ADA) criteria and de novo or intrahospital hyperglycemia as fasting plasma glucose (FPG) ≥140 mg/dL. Logistic and Cox proportional regression models were used to model risk for COVID-19 outcomes.
    Results: Overall, 159 cases (50.2%) had type 2 diabetes and 125 had pre-diabetes (39.4%), while 31.4% of patients with type 2 diabetes were previously undiagnosed. Among 20.0% of pre-diabetes cases and 6.1% of normal-range HbA1c had de novo hyperglycemia. FPG was the better predictor for critical COVID-19 compared with HbA1c. Undiagnosed type 2 diabetes (OR: 5.76, 95% CI 1.46 to 27.11) and pre-diabetes (OR: 4.15, 95% CI 1.29 to 16.75) conferred increased risk of severe COVID-19. De novo/intrahospital hyperglycemia predicted critical COVID-19 outcomes independent of diabetes status.
    Conclusions: Undiagnosed type 2 diabetes, pre-diabetes and de novo hyperglycemia are risk factors for critical COVID-19. HbA1c must be measured early to adequately assess individual risk considering the large rates of undiagnosed type 2 diabetes in Mexico.
    MeSH term(s) Adult ; Blood Glucose/analysis ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/mortality ; Cohort Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/mortality ; Fasting/blood ; Female ; Glycated Hemoglobin/analysis ; Hospitalization/statistics & numerical data ; Humans ; Male ; Mexico/epidemiology ; Middle Aged ; Prediabetic State/blood ; Prediabetic State/epidemiology ; Prediabetic State/mortality ; Prospective Studies ; Risk Factors ; SARS-CoV-2/genetics ; Severity of Illness Index ; Undiagnosed Diseases/complications ; Undiagnosed Diseases/epidemiology
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A
    Language English
    Publishing date 2021-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2732918-5
    ISSN 2052-4897 ; 2052-4897
    ISSN (online) 2052-4897
    ISSN 2052-4897
    DOI 10.1136/bmjdrc-2020-002026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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