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  1. Article: Inflammatory response following acute magnesium deficiency in the rat.

    Malpuech-Brugère, C / Nowacki, W / Daveau, M / Gueux, E / Linard, C / Rock, E / Lebreton, J / Mazur, A / Rayssiguier, Y

    Biochimica et biophysica acta

    1999  Volume 1501, Issue 2-3, Page(s) 91–98

    Abstract: ... of the present study was to characterize more precisely the acute phase response following Mg deficiency ... reconsidered but the sequence of events leading to the inflammatory response remains unclear. Thus, the purpose ... observed without plasma elevation of this neuropeptide. The fact that the inflammatory response was ...

    Abstract The importance of inflammatory processes in the pathology of Mg deficiency has been recently reconsidered but the sequence of events leading to the inflammatory response remains unclear. Thus, the purpose of the present study was to characterize more precisely the acute phase response following Mg deficiency in the rat. Weaning male Wistar rats were pair-fed either a Mg-deficient or a control diet for either 4 or 8 days. The characteristic allergy-like crisis of Mg-deficient rats was accompanied by a blood leukocyte response and changes in leukocytes subpopulations. A significant increase in interleukin-6 (IL-6) plasma level was observed in Mg-deficient rats compared to rats fed a control diet. The inflammatory process was accompanied by an increase in plasma levels of acute phase proteins. The concentrations of alpha2-macroglobulin and alpha1-acid glycoprotein in the plasma of Mg-deficient rats were higher than in control rats. This was accompanied in the liver by an increase in the level of mRNA coding for these proteins. Moreover, Mg-deficient rats showed a significant increase in plasma fibrinogen and a significant decrease in albumin concentrations. Macrophages found in greater number in the peritoneal cavity of Mg-deficient rats were activated endogenously and appeared to be primed for superoxide production following phorbol myristate acetate stimulation. A high plasma level of IL-6 could be detected as early as day 4 for the Mg-deficient diet. Substance P does not appear to be the initiator of inflammation since IL-6 increase was observed without plasma elevation of this neuropeptide. The fact that the inflammatory response was an early consequence of Mg deficiency suggests that reduced extracellular Mg might be responsible for the activated state of immune cells.
    MeSH term(s) Acute-Phase Proteins/metabolism ; Animals ; Animals, Newborn ; Diet ; Fibrinogen/metabolism ; Inflammation/immunology ; Interleukin-6/blood ; Leukocytes/immunology ; Leukocytes/metabolism ; Liver/metabolism ; Macrophage Activation ; Magnesium Deficiency/immunology ; Magnesium Deficiency/metabolism ; Male ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Serum Albumin/metabolism ; Tetradecanoylphorbol Acetate/pharmacology ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Acute-Phase Proteins ; Interleukin-6 ; RNA, Messenger ; Serum Albumin ; Tumor Necrosis Factor-alpha ; Fibrinogen (9001-32-5) ; Tetradecanoylphorbol Acetate (NI40JAQ945)
    Language English
    Publishing date 1999-04-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/s0925-4439(00)00018-1
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.247: Show issues Location:
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  2. Article: Inflammatory response following acute magnesium deficiency in the rat

    Malpuech-Brugere, C / Nowacki, W / Daveau, M / Gueux, E / Linard, C / Rock, E / Lebreton, J.P / Mazur, A / Rayssiguier, Y

    Biochimica et biophysica acta = International journal of biochemistry and biophysics. June 15, 2000. v. 1501 (2/3)

    2000  

    Keywords magnesium ; nutrient deficiencies
    Language English
    Dates of publication 2000-0615
    Size p. 91-98.
    Document type Article
    ZDB-ID 241742-x
    ISSN 0006-3002 ; 0921-9846
    ISSN 0006-3002 ; 0921-9846
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 65/183: Show issues

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  3. Article: Protective effect of calcium deficiency on the inflammatory response in magnesium-deficient rats.

    Bussière, Fraņoise I / Gueux, Elyett / Rock, Edmond / Mazur, Andrzej / Rayssiguier, Yves

    European journal of nutrition

    2002  Volume 41, Issue 5, Page(s) 197–202

    Abstract: ... of the acute phase response following Mg-deficiency in rats. ... whether dietary Ca-deficiency improves the abnormal inflammatory response of Mg-deficient rats.: Materials and ... inflammatory effect. Since magnesium (Mg) frequently acts as a natural calcium (Ca) antagonist, the possibility ...

    Abstract Background: Previous studies indicated that dietary Mg-deficiency in rats results in a marked pro-inflammatory effect. Since magnesium (Mg) frequently acts as a natural calcium (Ca) antagonist, the possibility exists that the pro-inflammatory effect of Mg-deficiency may be a consequence of a reduced extracellular Mg(2+)/Ca(2+) antagonism.
    Aim of the study: Thus, the aim of the study was to assess whether dietary Ca-deficiency improves the abnormal inflammatory response of Mg-deficient rats.
    Materials and methods: Weaning male Wistar rats were randomly divided into 4 groups according to the dietary Mg and Ca as follows: Mg-adequate Ca-adequate (control), Mg-adequate Ca-deficient, Mg-deficient Ca-adequate, Mg-deficient Ca-deficient. Animals were fed the appropriate diets for 8 days.
    Results: Mg-deficient Ca-adequate rats as compared to controls displayed the usual decrease in plasma Mg, whereas the plasma Ca concentration was unaffected. The classical symptoms of inflammation including hyperemia, increased number of blood leukocytes and increased spleen weight were observed. In addition, these animals also showed an increase in heart lipid peroxidation and in plasma triglyceride concentration. In Mg-deficient rats, Ca-deficiency induced hypocalcemia and offered a significant protection against the pro-inflammatory effect of Mg-deficiency. This was evidenced by lower inflammation scores, prevention of leukocytosis and of spleen enlargement. The protective effects of Ca-deficiency on the inflammatory response in Mg-deficiency was accompanied by significant reduction in lipid peroxidation and by a normalization of plasma triglyceride concentration.
    Conclusion: All together, the results suggest that Ca is implicated in the inflammatory response of experimental Mg-deficiency and that oxidative stress and hypertriglyceridemia are the results of the acute phase response following Mg-deficiency in rats.
    MeSH term(s) Animals ; Calcium/blood ; Calcium/deficiency ; Inflammation/immunology ; Leukocytes/immunology ; Lipid Peroxidation/drug effects ; Magnesium/blood ; Magnesium Deficiency/immunology ; Magnesium Deficiency/metabolism ; Male ; Organ Size ; Random Allocation ; Rats ; Rats, Wistar ; Spleen/immunology ; Spleen/pathology ; Triglycerides/blood
    Chemical Substances Triglycerides ; Magnesium (I38ZP9992A) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2002-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-002-0376-0
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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Marked alterations in circulating inflammatory cells during cardiomyopathy development in a magnesium-deficient rat model.

    Kurantsin-Mills, J / Cassidy, M M / Stafford, R E / Weglicki, W B

    The British journal of nutrition

    1997  Volume 78, Issue 5, Page(s) 845–855

    Abstract: ... of cardiovascular dysfunction. In the rat, inflammatory cell infiltration of the myocardium begins to occur by week ... levels of neutrophils and lymphocytes appeared to contribute to both the acute (week 1-2) and chronic ... pathophysiological changes observed in Mg-deficiency-induced cardiomyopathy, we analysed these cells by flow ...

    Abstract Rodents fed on a Mg-deficient (Mg-D) diet develop cardiomyopathic lesions, as well as other types of cardiovascular dysfunction. In the rat, inflammatory cell infiltration of the myocardium begins to occur by week 1, and the lesions develop extensively in the third and fourth weeks on the Mg-D diet. Although the aetiologic mechanisms of Mg-D cardiomyopathy are unknown, we have previously reported that once plasma Mg is markedly reduced, one of the earliest molecular markers of the pathophysiological process is elevation of plasma substance P, calcitonin gene-related peptide and prostaglandin E2, followed by histamine and the inflammatory cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-alpha). In order to evaluate the potential role of specific circulating inflammatory cell subpopulations in the mechanisms underlying pathophysiological changes observed in Mg-deficiency-induced cardiomyopathy, we analysed these cells by flow cytochemistry. Leucocyte subpopulation pools increased progressively in the Mg-D rats. Elevated circulating levels of neutrophils and lymphocytes appeared to contribute to both the acute (week 1-2) and chronic phases (week 3-4) of the inflammatory responses; monocytes, eosinophils, basophils and large unstained cells which are lymphoid in stained smears, on the other hand, increased significantly in the third and fourth weeks and thus contributed to the chronic inflammatory phase. Changes in the circulating leucocyte subpopulations paralleled the chronological progression of the cardiomyopathic lesions, particularly in weeks 3 and 4. Since a pronounced neutrophilia preceded leucocyte infiltration and deposition within the myocardial tissue, modifications of the microvascular barrier may be a prerequisite for cardiomyopathy in this model of neurogenic inflammation.
    MeSH term(s) Acute Disease ; Analysis of Variance ; Animals ; Basophils/immunology ; Cardiomyopathies/immunology ; Cardiomyopathies/pathology ; Chronic Disease ; Eosinophils/immunology ; Flow Cytometry ; Leukocyte Count ; Lymphocytes/immunology ; Magnesium Deficiency/immunology ; Magnesium Deficiency/pathology ; Male ; Myocardium/immunology ; Myocardium/pathology ; Neutrophils/immunology ; Rats ; Rats, Sprague-Dawley
    Language English
    Publishing date 1997-11
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    DOI 10.1079/bjn19970200
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    In stock of ZB MED Cologne/Königswinter

    Ue I Zs.184: Show issues Location:
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  5. Article: Marked alterations in circulating inflammatory cells during cardiomyopathy development in a magnesium-deficient rat model

    Kurantsin-Mills, J / Cassidy, M.M / Stafford, R.E / Weglicki, W.B

    British journal of nutrition. Nov 1997. v. 78 (5)

    1997  

    Abstract: ... of cardiovascular dysfunction. In the rat, inflammatory cell infiltration of the myocardium begins to occur by week ... levels of neutrophils and lymphocytes appeared to contribute to both the acute (week 1-2) and chronic ... pathophysiological changes observed in Mg-deficiency-induced cardiomyopathy, we analysed these cells by flow ...

    Abstract Rodents fed on a Mg-deficient (Mg-D) diet develop cardiomyopathic lesions, as well as other types of cardiovascular dysfunction. In the rat, inflammatory cell infiltration of the myocardium begins to occur by week 1, and the lesions develop extensively in the third and fourth weeks on the Mg-D diet. Although the aetiologic mechanisms of Mg-D cardiomyopathy are unknown, we have previously reported that once plasma Mg is markedly reduced, one of the earliest molecular markers of the pathophysiological process is elevation of plasma substance P, calcitonin gene-related peptide and prostaglandin E2, followed by histamine and the inflammatory cytokines (interleukin-1, interleukin-6, and tumor necrosis factor-alpha). In order to evaluate the potential role of specific circulating inflammatory cell subpopulations in the mechanisms underlying pathophysiological changes observed in Mg-deficiency-induced cardiomyopathy, we analysed these cells by flow cytochemistry. Leucocyte subpopulation pools increased progressively in the Mg-D rats. Elevated circulating levels of neutrophils and lymphocytes appeared to contribute to both the acute (week 1-2) and chronic phases (week 3-4) of the inflammatory responses; monocytes, eosinophils, basophils and large unstained cells which are lymphoid in stained smears, on the other hand, increased significantly in the third and fourth weeks and thus contributed to the chronic inflammatory phase. Changes in the circulating leucocyte subpopulations paralleled the chronological progression of the cardiomyopathic lesions, particularly in weeks 3 and 4. Since a pronounced neutrophilia preceded leucocyte infiltration and deposition within the myocardial tissue, modifications of the microvascular barrier may be a prerequisite for cardiomyopathy in this model of neurogenic inflammation.
    Keywords animal models ; inflammation ; experimental diets ; leukocytes ; nutrient deficiencies
    Language English
    Dates of publication 1997-11
    Size p. 845-855.
    Document type Article
    ZDB-ID 280396-3
    ISSN 1475-2662 ; 0007-1145
    ISSN (online) 1475-2662
    ISSN 0007-1145
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 916: Show issues

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