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Article ; Online: Hematologic changes predict clinical outcome in recovered patients with COVID-19.

Mao, Jian / Dai, Rong / Du, Rui-Chan / Zhu, Yan / Shui, Li-Ping / Luo, Xiao-Hua

2021 Volume 100, Issue 3, Page(s) 675–689

Abstract: ... of hematologic changes are associated with the severity and clinical outcome of recovered COVID-19 patients ... laboratory features of recovered COVID-19 patients without pre-existing hematologic diseases at Wuhan No. 1 ... 19. The levels of changes in leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, basophils ...

Abstract	2019 coronavirus disease (COVID-19) presents as a newly recognized pneumonia that has brought about a global pandemic and is increasingly considered as a systemic illness. We investigated the clinical and laboratory features of recovered COVID-19 patients without pre-existing hematologic diseases at Wuhan No. 1 Hospital. Fifty-nine male and 68 female Chinese patients were included with the median age at 64 years in the present study. Eosinopenia (37.80%), monocytosis (51.97%), lymphocytopenia (25.20%), and anemia (51.97%) were the most common hematologic findings in our cohort, particularly in severe or critically ill COVID-19. The levels of changes in leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, basophils, platelets, hemoglobin levels, mean corpuscular volume (MCV), and mean cell hemoglobin concentration (MCHC) are overall associated with lung involvement, oxygen demand, and disease activity. However, changes of eosinophils (end hospitalization-baseline) (coefficients = 10.32; 95% CI = 1.03-19.60, P = 0.03) and basophils (Max - Min) (coefficients = 71.43; 95% CI = 8.55-134.31, P = 0.03) were independent predictors of delayed recovery in the hospital by the multivariate analysis in this recovered population. A variety of hematologic changes are associated with the severity and clinical outcome of recovered COVID-19 patients, which warrants further exploration of their underlying mechanisms.
MeSH term(s)	Adult ; Aged ; Basophils ; Blood Cell Count ; C-Reactive Protein/analysis ; COVID-19/blood ; COVID-19/drug therapy ; COVID-19/epidemiology ; COVID-19/physiopathology ; COVID-19/therapy ; China ; Combined Modality Therapy ; Comorbidity ; Convalescence ; Diabetes Mellitus/blood ; Diabetes Mellitus/epidemiology ; Eosinophils ; Female ; Hemoglobins/analysis ; Humans ; Hypertension/blood ; Hypertension/epidemiology ; Interleukin-6/blood ; Lung/physiopathology ; Male ; Middle Aged ; Oxygen Inhalation Therapy ; Prognosis ; SARS-CoV-2 ; Treatment Outcome
Chemical Substances	Hemoglobins ; IL6 protein, human ; Interleukin-6 ; C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2021-02-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-021-04426-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China.

Chen, Ruchong / Sang, Ling / Jiang, Mei / Yang, Zhaowei / Jia, Nan / Fu, Wanyi / Xie, Jiaxing / Guan, Weijie / Liang, Wenhua / Ni, Zhengyi / Hu, Yu / Liu, Lei / Shan, Hong / Lei, Chunliang / Peng, Yixiang / Wei, Li / Liu, Yong / Hu, Yahua / Peng, Peng /

Wang, Jianming / Liu, Jiyang / Chen, Zhong / Li, Gang / Zheng, Zhijian / Qiu, Shaoqin / Luo, Jie / Ye, Changjiang / Zhu, Shaoyong / Zheng, Jinping / Zhang, Nuofu / Li, Yimin / He, Jianxing / Li, Jing / Li, Shiyue / Zhong, Nanshan

The Journal of allergy and clinical immunology

2020 Volume 146, Issue 1, Page(s) 89–100

Abstract: ... Methods: A retrospective study including 548 patients with COVID-19 with clarified outcome (discharged or ... disease 2019 (COVID-19) remain largely unclear.: Objective: We sought to address the dynamic changes ... in hematologic and immunologic biomarkers and their associations with severity and outcomes of COVID-19 ...

Abstract	Background: Crucial roles of hematologic and immunologic responses in progression of coronavirus disease 2019 (COVID-19) remain largely unclear. Objective: We sought to address the dynamic changes in hematologic and immunologic biomarkers and their associations with severity and outcomes of COVID-19. Methods: A retrospective study including 548 patients with COVID-19 with clarified outcome (discharged or deceased) from a national cohort in China was performed. Cross-sectional and longitudinal variations were compared and the associations with different severity and outcomes were analyzed. Results: On admission, the counts of lymphocytes, T-cell subsets, eosinophils, and platelets decreased markedly, especially in severe/critical and fatal patients. Increased neutrophil count and neutrophils-to-lymphocytes ratio were predominant in severe/critical cases or nonsurvivors. During hospitalization, eosinophils, lymphocytes, and platelets showed an increasing trend in survivors, but maintained lower levels or dropped significantly afterwards in nonsurvivors. Nonsurvivors kept a high level or showed an upward trend for neutrophils, IL-6, procalcitonin, D-dimer, amyloid A protein, and C-reactive protein, which were kept stable or showed a downward trend in survivors. Positive correlation between CD8 Conclusions: Hematologic and immunologic impairment showed a significantly different profile between survivors and nonsurvivors in patients with COVID-19 with different severity. The longitudinal variations in these biomarkers could serve to predict recovery or fatal outcome.
MeSH term(s)	Adult ; Aged ; Betacoronavirus ; Biomarkers/blood ; COVID-19 ; China ; Cohort Studies ; Coronavirus Infections/blood ; Coronavirus Infections/immunology ; Coronavirus Infections/mortality ; Cross-Sectional Studies ; Disease Progression ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/immunology ; Pneumonia, Viral/mortality ; Prognosis ; Retrospective Studies ; SARS-CoV-2
Chemical Substances	Biomarkers
Keywords	covid19
Language	English
Publishing date	2020-05-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2020.05.003
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Article ; Online: The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation.

Peçanha-Pietrobom, Paula M / Leite, Giuseppe Gianini Figueirêdo / Hunter, James / Ferreira, Paulo R Abrão / Burattini, Marcelo N / Bellei, Nancy / Ota-Arakaki, Jaquelina Sonoe / Salomao, Reinaldo

PloS one

2021 Volume 16, Issue 11, Page(s) e0258987

Abstract: ... patients. In conclusion, routine hematologic tests are useful to monitor the clinical course of COVID-19 ... Several studies of patients with COVID-19 have evaluated biological markers for predicting outcomes ... parameters to predict and mirror the patients' clinical course regarding the severity of their condition ...

Abstract	Several studies of patients with COVID-19 have evaluated biological markers for predicting outcomes, most of them retrospectively and with a wide scope of clinical severity. We followed a prospective cohort of patients admitted in hospital wards with moderate COVID-19 disease, including those with a history of kidney transplantation, and examined the ability of changes in routine hematologic laboratory parameters to predict and mirror the patients' clinical course regarding the severity of their condition (classified as critical vs. non-critical) and in-hospital mortality or hospital discharge. Among the 68 patients, 20 (29%) were kidney transplanted patients (KT), and they had much higher mortality than non-kidney transplanted patients in this cohort (40% X 8.3%). Lymphocytes, neutrophils and neutrophils/lymphocytes ratio (NLR) at admission and platelets as well as the red blood cells parameters hemoglobin, hematocrit, and RDW by the time of hospital discharge or death clearly differentiated patients progressing to critical disease and those with clinical recovery. Patients with deteriorating clinical courses presented elevated and similar NLRs during the first week of hospitalization. However, they were dramatically different at hospital discharge, with a decrease in the survivors (NLR around 5.5) and sustained elevation in non-survivors (NLR around 21). Platelets also could distinguish survivors from non-survivors among the critical patients. In conclusion, routine hematologic tests are useful to monitor the clinical course of COVID-19 patients admitted with moderate disease. Unexpectedly, changes in hematologic tests, including lymphopenia, were not predictive of complicated outcomes among KT recipients.
MeSH term(s)	Adult ; Aged ; Biomarkers/blood ; Blood Cells/pathology ; COVID-19/mortality ; Female ; Humans ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; Prognosis ; Prospective Studies
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-11-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0258987
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Article ; Online: The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation

Paula M. Peçanha-Pietrobom / Giuseppe Gianini Figueirêdo Leite / James Hunter / Paulo R. Abrão Ferreira / Marcelo N. Burattini / Nancy Bellei / Jaquelina Sonoe Ota-Arakaki / Reinaldo Salomao

PLoS ONE, Vol 16, Iss

2021 Volume 11

Abstract: ... patients. In conclusion, routine hematologic tests are useful to monitor the clinical course of COVID-19 ... Several studies of patients with COVID-19 have evaluated biological markers for predicting outcomes ... parameters to predict and mirror the patients’ clinical course regarding the severity of their condition ...

Abstract	Several studies of patients with COVID-19 have evaluated biological markers for predicting outcomes, most of them retrospectively and with a wide scope of clinical severity. We followed a prospective cohort of patients admitted in hospital wards with moderate COVID-19 disease, including those with a history of kidney transplantation, and examined the ability of changes in routine hematologic laboratory parameters to predict and mirror the patients’ clinical course regarding the severity of their condition (classified as critical vs. non-critical) and in-hospital mortality or hospital discharge. Among the 68 patients, 20 (29%) were kidney transplanted patients (KT), and they had much higher mortality than non-kidney transplanted patients in this cohort (40% X 8.3%). Lymphocytes, neutrophils and neutrophils/lymphocytes ratio (NLR) at admission and platelets as well as the red blood cells parameters hemoglobin, hematocrit, and RDW by the time of hospital discharge or death clearly differentiated patients progressing to critical disease and those with clinical recovery. Patients with deteriorating clinical courses presented elevated and similar NLRs during the first week of hospitalization. However, they were dramatically different at hospital discharge, with a decrease in the survivors (NLR around 5.5) and sustained elevation in non-survivors (NLR around 21). Platelets also could distinguish survivors from non-survivors among the critical patients. In conclusion, routine hematologic tests are useful to monitor the clinical course of COVID-19 patients admitted with moderate disease. Unexpectedly, changes in hematologic tests, including lymphopenia, were not predictive of complicated outcomes among KT recipients.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation.

Paula M Peçanha-Pietrobom / Giuseppe Gianini Figueirêdo Leite / James Hunter / Paulo R Abrão Ferreira / Marcelo N Burattini / Nancy Bellei / Jaquelina Sonoe Ota-Arakaki / Reinaldo Salomao

PLoS ONE, Vol 16, Iss 11, p e

2021 Volume 0258987

Abstract	Several studies of patients with COVID-19 have evaluated biological markers for predicting outcomes, most of them retrospectively and with a wide scope of clinical severity. We followed a prospective cohort of patients admitted in hospital wards with moderate COVID-19 disease, including those with a history of kidney transplantation, and examined the ability of changes in routine hematologic laboratory parameters to predict and mirror the patients' clinical course regarding the severity of their condition (classified as critical vs. non-critical) and in-hospital mortality or hospital discharge. Among the 68 patients, 20 (29%) were kidney transplanted patients (KT), and they had much higher mortality than non-kidney transplanted patients in this cohort (40% X 8.3%). Lymphocytes, neutrophils and neutrophils/lymphocytes ratio (NLR) at admission and platelets as well as the red blood cells parameters hemoglobin, hematocrit, and RDW by the time of hospital discharge or death clearly differentiated patients progressing to critical disease and those with clinical recovery. Patients with deteriorating clinical courses presented elevated and similar NLRs during the first week of hospitalization. However, they were dramatically different at hospital discharge, with a decrease in the survivors (NLR around 5.5) and sustained elevation in non-survivors (NLR around 21). Platelets also could distinguish survivors from non-survivors among the critical patients. In conclusion, routine hematologic tests are useful to monitor the clinical course of COVID-19 patients admitted with moderate disease. Unexpectedly, changes in hematologic tests, including lymphopenia, were not predictive of complicated outcomes among KT recipients.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Gut Microbiota Improves Prognostic Prediction in Critically Ill COVID-19 Patients Alongside Immunological and Hematological Indicators.

Zhong, Jiaxin / Guo, Li / Wang, Yeming / Jiang, Xuan / Wang, Chun / Xiao, Yan / Wang, Ying / Zhou, Fei / Wu, Chao / Chen, Lan / Wang, Xinming / Wang, Jianwei / Cao, Bin / Li, Mingkun / Ren, LiLi

Research (Washington, D.C.)

2024 Volume 7, Page(s) 389

Abstract: ... microbiota's dynamic change in critically ill patients with COVID-19 and evaluate its predictive capability ... The gut microbiota undergoes substantial changes in COVID-19 patients; yet, the utility ... in COVID-19 patients. Recovered patients exhibited a higher abundance of ...

Abstract	The gut microbiota undergoes substantial changes in COVID-19 patients; yet, the utility of these alterations as prognostic biomarkers at the time of hospital admission, and its correlation with immunological and hematological parameters, remains unclear. The objective of this study is to investigate the gut microbiota's dynamic change in critically ill patients with COVID-19 and evaluate its predictive capability for clinical outcomes alongside immunological and hematological parameters. In this study, anal swabs were consecutively collected from 192 COVID-19 patients (583 samples) upon hospital admission for metagenome sequencing. Simultaneously, blood samples were obtained to measure the concentrations of 27 cytokines and chemokines, along with hematological and biochemical indicators. Our findings indicate a significant correlation between the composition and dynamics of gut microbiota with disease severity and mortality in COVID-19 patients. Recovered patients exhibited a higher abundance of
Language	English
Publishing date	2024-05-22
Publishing country	United States
Document type	Journal Article
ISSN	2639-5274
ISSN (online)	2639-5274
DOI	10.34133/research.0389
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Article ; Online: Utility of hematological and inflammatory biomarkers in predicting recovery in critical Covid-19 patients: Our experience in the largest Covid-19 treating center in Lebanon.

Salame, Hassan / Nawfal, Rashad / Kassem, Jad / Mckey, Remy / Kassem, Ali / AlKhalil, Nayef / Saleh, Mohamad / Abdel Sater, Ali H / Ibrahim, Ali / Abou-Abbas, Linda / Eldbouni, Oussaima / Khatoun, Hoda / Matar, Bassam

PloS one

2022 Volume 17, Issue 7, Page(s) e0271393

Abstract: ... can be reliably used to follow COVID-19 patients in ICU and to support the decision to discharge patients. ... in the need to identify patients that can be discharged early before full clinical recovery. We designed ... this study to determine if in changes routine tests like CBCD and CRP can be a useful complement to clinical ...

Abstract	Background: COVID-19 pandemic has led to a catastrophic shortage of ICU beds. This has resulted in the need to identify patients that can be discharged early before full clinical recovery. We designed this study to determine if in changes routine tests like CBCD and CRP can be a useful complement to clinical status when deciding to discharge patients from ICU. Methods: This retrospective study was conducted in Rafic Hariri University Hospital. Levels of biomarkers measured at admission (T1) and within 3 days of outcome (T2) were collected and ratios (T2/T1) were calculated. The Odds Ratios of association between the changes in these biomarkers and outcome were estimated. Multivariate analysis and AUC for the performance of these biomarkers were also conducted. Results: We found on multivariate analysis that reduction in counts of lymphocyte and platelets and elevation in counts of neutrophils and level of CRP (T2/T1 ratio > 1) are strongly associated with mortality with respective ORs estimated at 6.74, 3.26, 5.65 and 4.34 [p-values < 0.001]. AUCs were found to lie in a range of 0.68 to 0.81 indicating fair to good performance. Other factors found to impact survival were AKI, AF and ACS [p-values < 0.01]. In contrast to other studies, risk factors didn't show an association with survival when adjusted for effects of complications and changes in biomarker levels. Conclusions: Our results confirm that inexpensive tests like lymphocyte count and CRP can be reliably used to follow COVID-19 patients in ICU and to support the decision to discharge patients.
MeSH term(s)	Biomarkers ; COVID-19/epidemiology ; Humans ; Lebanon/epidemiology ; Pandemics ; Prognosis ; Retrospective Studies
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0271393
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hematologic changes predict clinical outcome in recovered patients with COVID-19.

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Article ; Online: Longitudinal hematologic and immunologic variations associated with the progression of COVID-19 patients in China.

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Article ; Online: The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation.

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Article ; Online: The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation

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Inter-library loan at ZB MED

Article ; Online: The clinical course of hospitalized moderately ill COVID-19 patients is mirrored by routine hematologic tests and influenced by renal transplantation.

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Inter-library loan at ZB MED

Article ; Online: Gut Microbiota Improves Prognostic Prediction in Critically Ill COVID-19 Patients Alongside Immunological and Hematological Indicators.

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Article ; Online: Utility of hematological and inflammatory biomarkers in predicting recovery in critical Covid-19 patients: Our experience in the largest Covid-19 treating center in Lebanon.

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