Article ; Online: Characteristics and Outcomes of Heart Transplant Recipients With Coronavirus-19 Disease in a High-volume Transplant Center.
2021 Volume 106, Issue 3, Page(s) 641–647
Abstract: ... of HT recipients infected by SARS-COV-2, from a high-volume transplant center.: Methods: We have ... Background: Heart transplant (HT) recipients may be at higher risk of acquiring SARS-CoV-2 ... described data of all adult HT recipients with confirmed coronavirus disease 2019 by RT-PCR ...
| Abstract | Background: Heart transplant (HT) recipients may be at higher risk of acquiring SARS-CoV-2 infection and developing critical illness. The aim of this study is to describe characteristics and outcomes of HT recipients infected by SARS-COV-2, from a high-volume transplant center. Methods: We have described data of all adult HT recipients with confirmed coronavirus disease 2019 by RT-PCR in nasopharyngeal samples from April 5, 2020, to January 5, 2021. Outcomes and follow-up were recorded until February 5, 2021. Results: Forty patients were included. Twenty-four patients (60%) were men; the median age was 53 (40-60) y old; median HT time was 34 mo; and median follow-up time 162 d. The majority needed hospitalization (83%). Immunosuppressive therapy was reduced/withdrawn in the majority of patients, except from steroids, which were maintained. Seventeen patients (42.5%) were classified as having severe disease according to the ordinal scale developed by the World Health Organization Committee. They tended to have lower absolute lymphocyte count (P < 0.001) during follow-up when compared with patients with mild disease. Thirty-day mortality was 12.5%. However, a longer follow-up revealed increased later mortality (27.5%), with median time to death around 35 d. Bacterial nosocomial infections were a leading cause of death. Cardiac allograft rejection (10%) and ventricular dysfunction (12.5%) were also not negligible. Conclusions: Major findings of this study corroborate other cohorts' results, but it also reports significant rate of later events, suggesting that a strict midterm surveillance is advisable to HT recipients with coronavirus disease 2019. |
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| MeSH term(s) | Adult ; COVID-19 ; Heart Transplantation/adverse effects ; Hospitalization ; Humans ; Immunosuppression Therapy ; Male ; Middle Aged ; SARS-CoV-2 ; Transplant Recipients | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2021-03-11 | ||||||||||
| Publishing country | United States | ||||||||||
| Document type | Journal Article | ||||||||||
| ZDB-ID | 208424-7 | ||||||||||
| ISSN | 1534-6080 ; 0041-1337 | ||||||||||
| ISSN (online) | 1534-6080 | ||||||||||
| ISSN | 0041-1337 | ||||||||||
| DOI | 10.1097/TP.0000000000003770 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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