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  1. Article ; Online: Oral cancer and ACE2 receptor of SARS-CoV-2.

    Martelli-Júnior, Hercílio / Machado, Renato Assis / Martelli, Daniella Reis Barbosa / Andrade, Mariléia Chaves / Coletta, Ricardo D

    Oral oncology

    2020  Volume 108, Page(s) 104920

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Mouth Neoplasms ; Pandemics ; Peptidyl-Dipeptidase A ; Pneumonia, Viral ; SARS-CoV-2 ; Tobacco Smoking
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Keywords covid19
    Language English
    Publishing date 2020-07-21
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2020.104920
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  2. Article: Oral cancer and ACE2 receptor of SARS-CoV-2

    Martelli-Júnior, Hercílio / Machado, Renato Assis / Martelli, Daniella Reis Barbosa / Andrade, Mariléia Chaves / Coletta, Ricardo D

    Oral Oncol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #664638
    Database COVID19

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  3. Article ; Online: Oral cancer and ACE2 receptor of SARS-CoV-2

    Martelli-Júnior, Hercílio / Machado, Renato Assis / Martelli, Daniella Reis Barbosa / Andrade, Mariléia Chaves / Coletta, Ricardo D.

    Oral Oncology

    2020  Volume 108, Page(s) 104920

    Keywords Cancer Research ; Oral Surgery ; Oncology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2020.104920
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.

    Xu, Hao / Zhong, Liang / Deng, Jiaxin / Peng, Jiakuan / Dan, Hongxia / Zeng, Xin / Li, Taiwen / Chen, Qianming

    International journal of oral science

    2020  Volume 12, Issue 1, Page(s) 8

    Abstract: It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role ... to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell ... cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed ...

    Abstract It has been reported that ACE2 is the main host cell receptor of 2019-nCoV and plays a crucial role in the entry of virus into the cell to cause the final infection. To investigate the potential route of 2019-nCov infection on the mucosa of oral cavity, bulk RNA-seq profiles from two public databases including The Cancer Genome Atlas (TCGA) and Functional Annotation of The Mammalian Genome Cap Analysis of Gene Expression (FANTOM5 CAGE) dataset were collected. RNA-seq profiling data of 13 organ types with para-carcinoma normal tissues from TCGA and 14 organ types with normal tissues from FANTOM5 CAGE were analyzed in order to explore and validate the expression of ACE2 on the mucosa of oral cavity. Further, single-cell transcriptomes from an independent data generated in-house were used to identify and confirm the ACE2-expressing cell composition and proportion in oral cavity. The results demonstrated that the ACE2 expressed on the mucosa of oral cavity. Interestingly, this receptor was highly enriched in epithelial cells of tongue. Preliminarily, those findings have explained the basic mechanism that the oral cavity is a potentially high risk for 2019-nCoV infectious susceptibility and provided a piece of evidence for the future prevention strategy in dental clinical practice as well as daily life.
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/genetics ; Coronavirus Infections/transmission ; Databases, Genetic ; Epithelial Cells/metabolism ; Epithelial Cells/virology ; Gene Expression Profiling ; Humans ; Mouth Mucosa/enzymology ; Mouth Mucosa/virology ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/genetics ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Tongue/metabolism ; Tongue/virology
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-02-24
    Publishing country India
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2569849-7
    ISSN 2049-3169 ; 1674-2818
    ISSN (online) 2049-3169
    ISSN 1674-2818
    DOI 10.1038/s41368-020-0074-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Increased susceptibility of SARS-CoV2 infection on oral cancer patients; cause and effects: An hypothesis.

    Chauhan, Anshika / Ghoshal, Sushmita / Pal, Arnab

    Medical hypotheses

    2020  Volume 144, Page(s) 109987

    Abstract: ... studies that SARS-CoV-2 requires host enzyme Furin to activate receptor binding domain of its S protein ... and host Angiotensin Convertase Enzyme 2 (ACE2) is required as binding receptor, facilitating ... that patients with oral cancer have higher chances of SARS CoV2 infection. It is also hypothesised that there ...

    Abstract In 2019, a new coronavirus (SARS CoV2) infecting humans has emerged in Wuhan, China which caused an unprecedented pandemic involving at least 185 countries infecting 2.5 million people till date. This virus is transmitted directly or indirectly through the upper aerodigestive tract. As it is evident from the recent studies that SARS-CoV-2 requires host enzyme Furin to activate receptor binding domain of its S protein and host Angiotensin Convertase Enzyme 2 (ACE2) is required as binding receptor, facilitating the entry of virus into the host cell. Evidence from literature shows that oral cancer tissues as well as paracarcinoma tissue exhibit higher expression of both Furin and ACE2, giving rise to the hypothesis that patients with oral cancer have higher chances of SARS CoV2 infection. It is also hypothesised that there will be increased severity of disease due to facilitated entry of the virus into the cells. Therefore, we suggest oral cancer patients require extra attention during COVID-19 pandemic and re-evaluation of current treatment paradigms in oral oncology is also needed.
    MeSH term(s) Angiotensin-Converting Enzyme 2/biosynthesis ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/physiology ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/virology ; Disease Susceptibility ; Furin/genetics ; Furin/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Models, Biological ; Mouth Neoplasms/genetics ; Mouth Neoplasms/metabolism ; Mouth Neoplasms/virology ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Pandemics ; Protein Binding ; Receptors, Virus/biosynthesis ; Receptors, Virus/genetics ; Receptors, Virus/physiology ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/metabolism ; Up-Regulation ; Virus Internalization
    Chemical Substances Neoplasm Proteins ; Receptors, Virus ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; FURIN protein, human (EC 3.4.21.75) ; Furin (EC 3.4.21.75)
    Keywords covid19
    Language English
    Publishing date 2020-06-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109987
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    Zs.A 1132: Show issues Location:
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  6. Article ; Online: EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions.

    Varadarajan, Saranya / Balaji, Thodur Madapusi / Sarode, Sachin C / Sarode, Gargi S / Sharma, Nilesh K / Gondivkar, Shailesh / Gadbail, Amol / Patil, Shankargouda

    Medical hypotheses

    2020  Volume 143, Page(s) 110089

    Abstract: ... been regarded as a target for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ... potentially malignant disorders (OPMDs) in terms of EMMPRIN as a target for SARS-CoV-2. In the present paper ... We proposed that in the ACE-2 depleted situation in OSCC, EMMPRIN receptor might get high jacked by the COVID ...

    Abstract Extracellular matrix metalloproteinase inducer (EMMPRIN), which is also called BASIGIN/CD147, is a cell surface glycoprotein that belongs to the immunoglobulin superfamily and plays a significant role in intercellular recognition in immunology, cellular differentiation and development. Apart from ACE-2, recently EMMPRIN, has been regarded as a target for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attachment and entry into the host cell. Since one of the routes of entry for the virus is the oral cavity, it becomes imperative to percept oral comorbidities such oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) in terms of EMMPRIN as a target for SARS-CoV-2. In the present paper, it is proposed that OSCC, by the virtue of upregulation of EMMPRIN expression, increases the susceptibility to coronavirus disease (COVID-19). In turn, COVID-19 in OSCC patients causes exhaustion of EMMPRIN receptor due to binding with 'S' receptor leading to a downregulation of related carcinogenesis events. We proposed that in the ACE-2 depleted situation in OSCC, EMMPRIN receptor might get high jacked by the COVID-19 virus for the entry into the host cells. Apart from the anti-monoclonal antibody, it is recommended to explore the use of grape seed and skin containing mouthwash as an adjunct, which could also have anti EMMPRIN effects in patients with OSCC and OPMDs.
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Antibodies, Monoclonal ; Basigin/metabolism ; Betacoronavirus ; COVID-19 ; Carcinoma, Squamous Cell/complications ; Carcinoma, Squamous Cell/metabolism ; Coronavirus Infections/complications ; Coronavirus Infections/metabolism ; Disease Susceptibility ; Gene Expression Regulation, Neoplastic ; Grape Seed Extract ; Humans ; Mouth Neoplasms/complications ; Mouth Neoplasms/metabolism ; Mouthwashes ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/complications ; Pneumonia, Viral/metabolism ; Protein Binding ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal ; BSG protein, human ; Grape Seed Extract ; Mouthwashes ; Basigin (136894-56-9) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-07-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Increased susceptibility of SARS-CoV2 infection on oral cancer patients; cause and effects: An hypothesis

    Chauhan, Anshika / Ghoshal, Sushmita / Pal, Arnab

    Med Hypotheses

    Abstract: ... studies that SARS-CoV-2 requires host enzyme Furin to activate receptor binding domain of its S protein ... and host Angiotensin Convertase Enzyme 2 (ACE2) is required as binding receptor, facilitating ... that patients with oral cancer have higher chances of SARS CoV2 infection. It is also hypothesised that there ...

    Abstract In 2019, a new coronavirus (SARS CoV2) infecting humans has emerged in Wuhan, China which caused an unprecedented pandemic involving at least 185 countries infecting 2.5 million people till date. This virus is transmitted directly or indirectly through the upper aerodigestive tract. As it is evident from the recent studies that SARS-CoV-2 requires host enzyme Furin to activate receptor binding domain of its S protein and host Angiotensin Convertase Enzyme 2 (ACE2) is required as binding receptor, facilitating the entry of virus into the host cell. Evidence from literature shows that oral cancer tissues as well as paracarcinoma tissue exhibit higher expression of both Furin and ACE2, giving rise to the hypothesis that patients with oral cancer have higher chances of SARS CoV2 infection. It is also hypothesised that there will be increased severity of disease due to facilitated entry of the virus into the cells. Therefore, we suggest oral cancer patients require extra attention during COVID-19 pandemic and re-evaluation of current treatment paradigms in oral oncology is also needed.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #592474
    Database COVID19

    Kategorien

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